Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 64, Issue -, Pages 630-635Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/jmm.0.000069
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Funding
- MagicBullet study
- European Union - Directorate General for Research and Innovation through the Seventh Framework Program for Research and Development [278232]
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The increasing emergence of multidrug-resistant Acinetobacter baumannii constitutes a worldwide threat in hospital settings. Efflux-mediated resistance, particularly the resistance-nodulation-division (RND)-type efflux pumps, contributes significantly to decreased susceptibility to multiple antibiotics when overexpressed. Using PCR-based detection, the prevalence of genes encoding the RND efflux pumps AdeB, AdeJ and AdeG was investigated amongst 144 epidemiologically characterized and geographically diverse A. baumannii isolates of worldwide origin, representing International Clones 1-8 and genotypically unique isolates. Furthermore, five putative RND-type efflux genes identified via an in silico approach were included. Five of the eight investigated efflux pump genes were present in all isolates, including adeJ and adeG; the prevalence of the others varied between 65 and 97%. No association between the presence of one or multiple pumps to a specific clonal lineage was detected. The high prevalence of the efflux pump genes supports a fixed function of each individual pump that is not yet fully understood.
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