标题
Hybrid antibiotics – clinical progress and novel designs
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 11, Issue 7, Pages 665-680
出版商
Informa UK Limited
发表日期
2016-05-12
DOI
10.1080/17460441.2016.1187597
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors
- (2016) Wenjuan Xie et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Understanding the mechanisms and drivers of antimicrobial resistance
- (2016) Alison H Holmes et al. LANCET
- Alternatives to antibiotics—a pipeline portfolio review
- (2016) Lloyd Czaplewski et al. LANCET INFECTIOUS DISEASES
- Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes
- (2016) Juan Pablo Maianti et al. MedChemComm
- Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy
- (2015) Bala Kishan Gorityala et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Multicenter, Double-Blind, Randomized, Phase 2 Study Evaluating the Novel Antibiotic Cadazolid in Patients with Clostridium difficile Infection
- (2015) Thomas Louie et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies
- (2015) Siva S. Panda et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space
- (2015) Audrey G. Ross et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Some Anti-Inflammatory Agents Inhibit Esterase Activities of Human Carbonic Anhydrase Isoforms I and II: AnIn VitroStudy
- (2015) Zuhal Alım et al. Chemical Biology & Drug Design
- Analysis of effects of MCB3681, the antibacterially active substance of prodrug MCB3837, on human resident microflora as proof of principle
- (2015) A. Dalhoff et al. CLINICAL MICROBIOLOGY AND INFECTION
- Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids
- (2015) Tomasz Plech et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Susceptibility ofClostridium difficileisolates from a Phase 2 clinical trial of cadazolid and vancomycin inC. difficileinfection
- (2015) D. N. Gerding et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents
- (2015) Angie M. Jarrad et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel lead generation of an anti-tuberculosis agent active against non-replicating mycobacteria: exploring hybridization of pyrazinamide with multiple fragments
- (2015) Shankar D. Markad et al. MEDICINAL CHEMISTRY RESEARCH
- Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids
- (2015) Tomasz Plech et al. MOLECULES
- Design of dual action antibiotics as an approach to search for new promising drugs
- (2015) A N Tevyashova et al. RUSSIAN CHEMICAL REVIEWS
- In vitro activity of MCB3681 against Clostridium difficile strains
- (2014) Mamun-Ur Rashid et al. ANAEROBE
- Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent
- (2014) Xu-Dong Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis, and biological evaluation of dihydroartemisinin–fluoroquinolone conjugates as a novel type of potential antitubercular agents
- (2014) Fu-Wei Zhou et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review
- (2014) Lissa Tsutsumi et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- An analysis of FDA-approved drugs for infectious disease: antibacterial agents
- (2014) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin
- (2014) Sheng-Feng Cui et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms
- (2014) Zhu-Ping Xiao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Multifunctional compounds: Smart molecules for multifactorial diseases
- (2014) Yogita Bansal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Ecological impact of MCB3837 on the normal human microbiota
- (2014) Mamun-Ur Rashid et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Lowenstein-Jensen Selective Medium for Reducing Contamination in Mycobacterium tuberculosis Culture
- (2014) K. Kassaza et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases
- (2014) Neelu Kaila et al. JOURNAL OF MEDICINAL CHEMISTRY
- Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli
- (2014) Tengfei Zheng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Design and synthesis of novel miconazole-based ciprofloxacin hybrids as potential antimicrobial agents
- (2014) Xiao-Long Gu et al. MONATSHEFTE FUR CHEMIE
- Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy
- (2014) Agnieszka Górska et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Challenges and future prospects of antibiotic therapy: from peptides to phages utilization
- (2014) Santi M. Mandal et al. Frontiers in Pharmacology
- Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa
- (2013) Christian van Delden et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Contribution of β-Lactamases and Porin Proteins OmpK35 and OmpK36 to Carbapenem Resistance in Clinical Isolates of KPC-2-Producing Klebsiella pneumoniae
- (2013) Ying Zhang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Synthesis and study of antibacterial activities of antibacterial glycopeptide antibiotics conjugated with benzoxaboroles
- (2013) SS Printsevskaya et al. Future Medicinal Chemistry
- Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple oral doses
- (2013) D. Baldoni et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Synthesis and Evaluation of Hetero- and Homodimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in Vitro Inhibition of Translation, and Drug Resistance
- (2013) Yifat Berkov-Zrihen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biscatecholate–Monohydroxamate Mixed Ligand Siderophore–Carbacephalosporin Conjugates are Selective Sideromycin Antibiotics that Target Acinetobacter baumannii
- (2013) Timothy A. Wencewicz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Platforms for antibiotic discovery
- (2013) Kim Lewis NATURE REVIEWS DRUG DISCOVERY
- Combination approaches to combat multidrug-resistant bacteria
- (2013) Roberta J. Worthington et al. TRENDS IN BIOTECHNOLOGY
- Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma
- (2013) Sina Haftchenary et al. ACS Medicinal Chemistry Letters
- Population Pharmacokinetics of Palivizumab, a Humanized Anti-Respiratory Syncytial Virus Monoclonal Antibody, in Adults and Children
- (2012) Gabriel J. Robbie et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Neomycin–phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding
- (2012) Brandon Findlay et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents
- (2012) Yan Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Combination Therapy for Treatment of Infections with Gram-Negative Bacteria
- (2012) P. D. Tamma et al. CLINICAL MICROBIOLOGY REVIEWS
- Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria
- (2012) Tomasz Plech et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Challenges of Antibacterial Discovery
- (2011) L. L. Silver CLINICAL MICROBIOLOGY REVIEWS
- Ionization of Carbon Acids in Liquid Ammonia
- (2011) Pengju Ji et al. ORGANIC LETTERS
- Discovery of 4′′-Ether Linked Azithromycin-Quinolone Hybrid Series: Influence of the Central Linker on the Antibacterial Activity
- (2011) Dražen Pavlović et al. ACS Medicinal Chemistry Letters
- Berberine-INF55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects of Varying the Relative Orientation of the Berberine and INF55 Components
- (2010) D. Tomkiewicz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli
- (2010) M. G. P. Page et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Multiresistant Gram-negative infections: a global perspective
- (2010) Jennifer Ho et al. CURRENT OPINION IN INFECTIOUS DISEASES
- Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety
- (2010) Tomasz Plech et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance
- (2010) Varvara Pokrovskaya et al. Expert Opinion on Drug Discovery
- Overview perspective of bacterial resistance
- (2010) Guilherme H Furtado et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Has the era of untreatable infections arrived?
- (2009) D. M. Livermore JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Drug interactions and the evolution of antibiotic resistance
- (2009) Pamela J. Yeh et al. NATURE REVIEWS MICROBIOLOGY
- In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies with Staphylococci and Streptococci
- (2008) G. T. Robertson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus
- (2008) G. T. Robertson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Drug interactions modulate the potential for evolution of resistance
- (2008) J.-B. Michel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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