Recent advances in oral delivery of peptide hormones

Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone Analogs

(2015) Shayli Varasteh Moradi et al.   AAPS Journal

In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue

(2015) Shayli Varasteh Moradi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Safety and Efficacy of Oral Octreotide in Acromegaly: Results of a Multicenter Phase III Trial

(2015) Shlomo Melmed et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Salmon Calcitonin Use and Associated Cancer Risk

(2014) Robert A. Overman et al.   ANNALS OF PHARMACOTHERAPY

Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: Strategies and industrial perspectives

(2014) Vivek K. Pawar et al.   JOURNAL OF CONTROLLED RELEASE

The Transport and Efflux of Glycosylated Luteinising Hormone-Releasing Hormone Analogues in Caco-2 Cell Model: Contributions of Glucose Transporters and Efflux Systems

(2014) Shayli Varasteh Moradi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Improved Oral Bioavailability of Human Growth Hormone by a Combination of Liposomes Containing Bio-Enhancers and Tetraether Lipids and Omeprazole

(2014) Johannes Parmentier et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial

(2014) N. Binkley et al.   OSTEOPOROSIS INTERNATIONAL

Oral Delivery of Exenatide via Microspheres Prepared by Cross-Linking of Alginate and Hyaluronate

(2014) Baojie Zhang et al.   PLoS One

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

Approaches for enhancing oral bioavailability of peptides and proteins

(2013) Jwala Renukuntla et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) Test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency

(2013) J. M. Garcia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Current and future applications of GnRH, kisspeptin and neurokinin B analogues

(2013) Robert P. Millar et al.   Nature Reviews Endocrinology

Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1–31)NH2] in postmenopausal women with osteoporosis

(2012) K. Henriksen et al.   BONE

Time–Action Profile of an Oral Enteric Insulin Formulation in Healthy Chinese Volunteers

(2012) Jiaqi Li et al.   CLINICAL THERAPEUTICS

Models to Predict Intestinal Absorption of Therapeutic Peptides and Proteins

(2012) Filipa Antunes et al.   CURRENT DRUG METABOLISM

Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration

(2012) Friederike M. Mansfeld et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intestinal Expression of MouseAbcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway

(2012) Ahmed M. Hamdan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The oral calcitonin in postmenopausal osteoporosis (ORACAL) trial

(2012) Neil Binkley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Oral Octreotide Absorption in Human Subjects: Comparable Pharmacokinetics to Parenteral Octreotide and Effective Growth Hormone Suppression

(2012) S. Tuvia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting the glucagon receptor family for diabetes and obesity therapy

(2012) Young Min Cho et al.   PHARMACOLOGY & THERAPEUTICS

Oral Delivery System for Two-pulse Colonic Release of Protein Drugs and Protease Inhibitor/Absorption Enhancer Compounds

(2011) Maria Dorly Del Curto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Probing the Production of Amidated Peptides following Genetic and Dietary Copper Manipulations

(2011) Ping Yin et al.   PLoS One

Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice

(2011) Edward T. Maggio et al.   REGULATORY PEPTIDES

Development of a process to manufacture PEGylated orally bioavailable insulin

(2010) Partha Hazra et al.   BIOTECHNOLOGY PROGRESS

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Is There Still a Role for Desmopressin in Children with Primary Monosymptomatic Nocturnal Enuresis?

(2010) Johan Van de Walle et al.   DRUG SAFETY

Oral salmon calcitonin – pharmacology in osteoporosis

(2010) Kim Henriksen et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

NP-647, a novel TRH analogue: Investigating physicochemical parameters critical for its oral and parenteral delivery

(2010) Kailas Khomane et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

To protect peptide pharmaceuticals against peptidases

(2010) R. Rink et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Orally Administered Glucagon-Like Peptide-1 Affects Glucose Homeostasis Following an Oral Glucose Tolerance Test in Healthy Male Subjects

(2009) R E Steinert et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Open-label study to assess the safety and pharmacodynamics of five oral insulin formulations in healthy subjects

(2009) R. Eldor et al.   DIABETES OBESITY & METABOLISM

Human growth hormone–transferrin fusion protein for oral delivery in hypophysectomized rats

(2009) Nurmamet Amet et al.   JOURNAL OF CONTROLLED RELEASE

Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity

(2009) Claudio Mapelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Unstirred Water Layer in In Vitro Permeability Experiments

(2009) Timo Korjamo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antiepileptic potential and behavioral profile of l-pGlu-(2-propyl)–l-His–l-ProNH2, a newer thyrotropin-releasing hormone analog

(2008) Satyendra Kumar Rajput et al.   EPILEPSY & BEHAVIOR

Novel Erythropoiesis-Stimulating Agents: A New Era in Anemia Management

(2007) I. C. Macdougall   Clinical Journal of the American Society of Nephrology