Current and future applications of GnRH, kisspeptin and neurokinin B analogues
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Title
Current and future applications of GnRH, kisspeptin and neurokinin B analogues
Authors
Keywords
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Journal
Nature Reviews Endocrinology
Volume 9, Issue 8, Pages 451-466
Publisher
Springer Nature
Online
2013-07-02
DOI
10.1038/nrendo.2013.120
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Note: Only part of the references are listed.- Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism
- (2012) Jyothis T. George et al. CLINICAL ENDOCRINOLOGY
- Direct Regulation of GnRH Neuron Excitability by Arcuate Nucleus POMC and NPY Neuron Neuropeptides in Female Mice
- (2012) Juan Roa et al. ENDOCRINOLOGY
- Chronic Administration of the Metastin/Kisspeptin Analog KISS1-305 or the Investigational Agent TAK-448 Suppresses Hypothalamic Pituitary Gonadal Function and Depletes Plasma Testosterone in Adult Male Rats
- (2012) Hisanori Matsui et al. ENDOCRINOLOGY
- Uncovering Novel Reproductive Defects in Neurokinin B Receptor Null Mice: Closing the Gap Between Mice and Men
- (2012) Jasmine J. Yang et al. ENDOCRINOLOGY
- Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback
- (2012) J. T. George et al. HUMAN REPRODUCTION
- Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications
- (2012) Jacques Young et al. NEUROENDOCRINOLOGY
- InactivatingKISS1Mutation and Hypogonadotropic Hypogonadism
- (2012) A. Kemal Topaloglu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
- (2012) Leonor Pinilla et al. PHYSIOLOGICAL REVIEWS
- New Insights into the Control of Pulsatile GnRH Release: The Role of Kiss1/Neurokinin B Neurons
- (2012) Víctor M. Navarro Frontiers in Endocrinology
- Regulation of NKB Pathways and Their Roles in the Control of Kiss1 Neurons in the Arcuate Nucleus of the Male Mouse
- (2011) V. M. Navarro et al. ENDOCRINOLOGY
- Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence
- (2011) Jeremy T. Smith et al. ENDOCRINOLOGY
- Developmental Changes in GnRH Release in Response to Kisspeptin Agonist and Antagonist in Female Rhesus Monkeys (Macaca mulatta): Implication for the Mechanism of Puberty
- (2011) Kathryn A. Guerriero et al. ENDOCRINOLOGY
- Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men
- (2011) J. T. George et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor
- (2011) Kazuhiro Miwa et al. JOURNAL OF MEDICINAL CHEMISTRY
- Frequency-Dependent Recruitment of Fast Amino Acid and Slow Neuropeptide Neurotransmitter Release Controls Gonadotropin-Releasing Hormone Neuron Excitability
- (2011) X. Liu et al. JOURNAL OF NEUROSCIENCE
- Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility
- (2011) Victor M. Navarro et al. Nature Reviews Endocrinology
- Evidence from the Agonadal Juvenile Male Rhesus Monkey (Macaca mulatta) for the View that the Action of Neurokinin B to Trigger Gonadotropin-Releasing Hormone Release Is Upstream from the Kisspeptin Receptor
- (2011) Suresh Ramaswamy et al. NEUROENDOCRINOLOGY
- Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases?
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- Synthesis and structure–activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54
- (2010) Toshitake Kobayashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 2-Acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats
- (2010) Toshitake Kobayashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology
- (2010) Robert P. Millar et al. BRAIN RESEARCH
- Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
- (2010) Heather J. Billings et al. ENDOCRINOLOGY
- Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
- (2010) Michael N. Lehman et al. ENDOCRINOLOGY
- Evolution of GnRH: Diving deeper
- (2010) Graeme J. Roch et al. GENERAL AND COMPARATIVE ENDOCRINOLOGY
- TAC3/TACR3Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood
- (2010) Elena Gianetti et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- TAC3andTACR3Defects Cause Hypothalamic Congenital Hypogonadotropic Hypogonadism in Humans
- (2010) Jacques Young et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
- (2010) Jose Donato et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2010) Y. Wakabayashi et al. JOURNAL OF NEUROSCIENCE
- Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes
- (2010) Jyothis T. George et al. NEUROENDOCRINOLOGY
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- (2010) Yan Li et al. XENOBIOTICA
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- (2009) Amy E. Oakley et al. ENDOCRINE REVIEWS
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- (2009) M. Amstalden et al. JOURNAL OF NEUROENDOCRINOLOGY
- Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation
- (2009) A. K. Roseweir et al. JOURNAL OF NEUROSCIENCE
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- (2008) J. M. Castellano et al. ENDOCRINOLOGY
- Gonadotropin-releasing hormone and ovarian cancer: a functional and mechanistic overview
- (2008) Wai-Kin So et al. FEBS Journal
- The role of kisspeptin in the control of gonadotrophin secretion
- (2008) A.K. Roseweir et al. HUMAN REPRODUCTION UPDATE
- Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix
- (2008) R. Scott Struthers et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2008) Chen Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- G protein-coupled receptors of the hypothalamic-pituitary-gonadal axis: A case for gnrh, LH, FSH, and GPR54 receptor ligands
- (2008) Laura H. Heitman et al. MEDICINAL RESEARCH REVIEWS
- TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction
- (2008) A Kemal Topaloglu et al. NATURE GENETICS
- Comparison of the effects of peripherally administered kisspeptins
- (2008) Jens D. Mikkelsen et al. REGULATORY PEPTIDES
- Mammalian Type I Gonadotropin-Releasing Hormone Receptors Undergo Slow, Constitutive, Agonist-Independent Internalization
- (2007) Adam J. Pawson et al. ENDOCRINOLOGY
- Diversity of actions of GnRHs mediated by ligand-induced selective signaling
- (2007) Robert P. Millar et al. FRONTIERS IN NEUROENDOCRINOLOGY
- New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
- (2007) Juan Roa et al. FRONTIERS IN NEUROENDOCRINOLOGY
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