Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Orthopedics
Li Cao, Wei Wu, Xiangyu Deng, Haoyu Guo, Feifei Pu, Zengwu Shao
Summary: This study examined the relationship between total cholesterol and total bone mineral density (BMD) among 10,039 US participants. The results showed a negative correlation between total cholesterol levels and total BMD among participants aged 20-29 years. In other races, this relationship exhibited a nonlinear association, with an inflection point. Therefore, maintaining a reasonable total cholesterol level may be an approach to prevent osteoporosis or osteopenia in young adults and individuals with diabetes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nutrition & Dietetics
Mariangela Rondanelli, Milena Anna Faliva, Gaetan Claude Barrile, Alessandro Cavioni, Francesca Mansueto, Giuseppe Mazzola, Letizia Oberto, Zaira Patelli, Martina Pirola, Alice Tartara, Antonella Riva, Giovanna Petrangolini, Gabriella Peroni
Summary: This review evaluates the ideal dietary approach to reduce bone mineral density loss and suggests a food pyramid for osteopenia/osteoporosis patients. The pyramid emphasizes daily consumption of carbohydrates, fruits, vegetables, light yogurt, skim milk, extra virgin olive oil, and calcium water. Weekly portions include fish, white meat, legumes, eggs, cheeses, and red/processed meats. The pyramid also highlights the need for personalized supplementation and identifies certain foods to be avoided. Additionally, regular aerobic and resistance exercises are recommended.
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Zijian Yan, Xianmei Xiong, Jiasheng Tao, Sheng Wang
Summary: This cross-sectional study found no significant association between urinary levels of 2,4,5-trichlorophenol (TCP) and 2,4,6-trichlorophenol and bone mineral density (BMD) in the US population, suggesting that TCP may not be detrimental to BMD.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Nutrition & Dietetics
Francisco Javier Martinez-Noguera, Pedro E. Alcaraz, Raquel Ortolano-Rios, Cristian Marin-Pagan
Summary: Cycling has a negative impact on bone health, and one season of professional cycling results in a decrease in bone mineral density, bone mineral content, and bone area. This finding is important for the performance and health management of athletes, as well as for the economic and social impact.
Article
Nutrition & Dietetics
Maryam Pourhassan, Bjoern Buehring, Ulrik Stervbo, Sven Rahmann, Felix Moelder, Sebastian Ruetten, Ulrike Trampisch, Nina Babel, Timm Henning Westhoff, Rainer Wirth
Summary: The study found that osteoporosis and sarcopenia are common in older hospitalized patients, with some overlap between the two conditions known as osteosarcopenia. Nearly all sarcopenic patients also had osteoporosis, while only a small percentage of patients with low BMD also had sarcopenia.
Article
Biochemistry & Molecular Biology
Shereen M. Aleidi, Mysoon M. Al-Ansari, Eman A. Alnehmi, Abeer K. Malkawi, Ahmad Alodaib, Mohamed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: The study revealed distinct lipidomics profiles between LBMD and Ctrl groups, with 322 dysregulated lipid molecules identified, primarily in subclasses such as PC, TG, and PE. These findings offer insights into lipidomics alterations associated with bone remodeling and LBMD, potentially guiding the development of therapeutic targets and nutritional strategies for managing OP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mysoon M. Al-Ansari, Shereen M. Aleidi, Afshan Masood, Eman A. Alnehmi, Mai Abdel Jabar, Maha Almogren, Mohammed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: This study investigated sensitive and specific LBMD-associated protein biomarkers in patients diagnosed with ON and OP. The results identified distinctive proteomics profiles between the control, ON, and OP groups, as well as significant dysregulation in a panel of proteins common among the three groups. A comparison of proteins showed differences in their levels between ON and the control group, as well as between ON and OP. These findings provide potential protein biomarkers for further research on bone health and OP progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Ruijie Xie, Xiongjie Huang, Qianlong Liu, Mingjiang Liu
Summary: This study found a positive relationship between HDL-C levels and lumbar bone mineral density (BMD) in individuals aged 20-59. The relationship was maintained in women and blacks but not in men and whites. In men and whites, the relationship followed a U-shaped curve with the same inflection point of 0.98 mmol/L. HDL-C measurement could be used as a sensitive biomarker for early detection of osteoporosis and guiding therapy.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Tang, Shenghong Wang, Qiong Yi, Yayi Xia, Bin Geng
Summary: This study found an inverse correlation between HDL-C levels and BMD, especially prominent in females, where high HDL-C levels may indicate an increased risk of osteoporosis, requiring close monitoring of BMD and early intervention.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atila Gokcek, Esra Ogutcu Karabay, Merve Aktimur Yegin, Emin Cakmakci, Serap Gencer
Summary: This study aimed to describe a more accessible and safe diagnostic tool for osteoporosis or osteopenia diagnosis. The cortical thickness (CoT) measurement of various bones via ultrasonography was evaluated for its accuracy in relation to bone mineral density (BMD) determined by dual-energy X-ray absorptiometry (DXA). The results showed that CoT measurements of certain bones were significantly higher in osteoporotic or osteopenic patients compared to controls.
ACADEMIC RADIOLOGY
(2023)
Review
Nursing
Shifang Zhang, Xiuxiu Huang, Xiaoyan Zhao, Bei Li, Ying Cai, Xiaoqin Liang, Qiaoqin Wan
Summary: The study systematically reviewed and compared different exercise interventions on bone mineral density in patients with osteoporosis and osteopenia. The findings indicated that mind-body exercise was most effective in increasing BMD in the lumbar spine and femoral neck, while resistance exercise showed promising results for total hip BMD.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Immunology
Yuchen Tang, Bo Peng, Jinmin Liu, Zhongcheng Liu, Yayi Xia, Bin Geng
Summary: This study explores the association between systemic immune-inflammation index (SII) and bone mineral density (BMD) in postmenopausal women. The results suggest that higher SII is associated with lower BMD and increased risk of osteoporosis. Other inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR) and the product of platelet count and neutrophil count (PPN), are also negatively associated with BMD and positively associated with the risk of osteoporosis. These associations are more significant in postmenopausal women aged >=65 years or with normal BMI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shereen M. Aleidi, Eman A. Alnehmi, Mohammed Alshaker, Afshan Masood, Hicham Benabdelkamel, Mysoon M. Al-Ansari, Anas M. Abdel Rahman
Summary: This study used an untargeted mass spectrometry-based metabolomics approach to analyze serum samples of patients with low BMD, finding significant differences in metabolic processes between LBMD patients and controls. Various metabolic pathways, including histidine metabolism and aminoacyl-tRNA biosynthesis, were dysregulated in LBMD. Differences in metabolite levels were also observed between osteopenia (ON) and osteoporosis (OP) groups, with certain metabolites upregulated in ON and downregulated in OP. These findings contribute to understanding metabolic alterations associated with LBMD, ON, and OP, and aid in developing prediction models for bone health and OP progression.