Nonviral Gene Delivery with the Sleeping Beauty Transposon System

Scaffold/Matrix Attached Region-Based Nonviral Episomal Vectors

(2011) Claudia Hagedorn et al.   HUMAN GENE THERAPY

Comparative Genomic Integration Profiling of Sleeping Beauty Transposons Mobilized With High Efficacy From Integrase-defective Lentiviral Vectors in Primary Human Cells

(2011) Brian Moldt et al.   MOLECULAR THERAPY

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

(2011) Melanie Galla et al.   NUCLEIC ACIDS RESEARCH

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

(2010) Zsuzsanna Izsvák et al.   BIOESSAYS

Herpes Simplex Virus/Sleeping Beauty Vector-Based Embryonic Gene Transfer Using the HSB5 Mutant: Loss of Apparent Transposition Hyperactivity In Vivo

(2010) Suresh de Silva et al.   HUMAN GENE THERAPY

Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B

(2010) Martin A Hausl et al.   MOLECULAR THERAPY

Comparative Analysis of Transposable Element Vector Systems in Human Cells

(2010) Ivana Grabundzija et al.   MOLECULAR THERAPY

A Transposon and Transposase System for Human Application

(2010) Perry B Hackett et al.   MOLECULAR THERAPY

Novel Hyperactive Transposons for Genetic Modification of Induced Pluripotent and Adult Stem Cells: A Nonviral Paradigm for Coaxed Differentiation

(2010) Eyayu Belay et al.   STEM CELLS

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

(2009) T. VandenDriessche et al.   BLOOD

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system

(2009) X. Xue et al.   BLOOD

A Fresh Look at iPS Cells

(2009) Shinya Yamanaka   CELL

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

(2009) P D Peng et al.   GENE THERAPY

Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon

(2009) Xia Wang et al.   HEPATOLOGY

Stable Transgene Expression in Primitive Human CD34+ Hematopoietic Stem/Progenitor Cells, Using the Sleeping Beauty Transposon System

(2009) Teiko Sumiyoshi et al.   HUMAN GENE THERAPY

Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors

(2009) Z IZSVAK   METHODS

Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

(2009) Nicklas H Staunstrup et al.   MOLECULAR THERAPY

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

(2009) Ute Modlich et al.   MOLECULAR THERAPY

Sleeping Beauty Transposition From Nonintegrating Lentivirus

(2009) Conrad A Vink et al.   MOLECULAR THERAPY

Systemic Correction of Storage Disease in MPS I NOD/SCID Mice Using the Sleeping Beauty Transposon System

(2009) Elena L Aronovich et al.   MOLECULAR THERAPY

Embryonic stem cells use ZFP809 to silence retroviral DNAs

(2009) Daniel Wolf et al.   NATURE

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Transposon-mediated genome manipulation in vertebrates

(2009) Zoltán Ivics et al.   NATURE METHODS

Applying a “Double-Feature” Promoter to Identify Cardiomyocytes Differentiated from Human Embryonic Stem Cells Following Transposon-Based Gene Delivery

(2009) Tamás I. Orbán et al.   STEM CELLS

Redirecting Specificity of T-Cell Populations For CD19 Using the Sleeping Beauty System

(2008) H. Singh et al.   CANCER RESEARCH

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted gene insertion for molecular medicine

(2008) Katrin Voigt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sleeping Beauty Vector System Moves Toward Human Trials in the United States

(2008) David A Williams   MOLECULAR THERAPY

Computer-assisted Hydrodynamic Gene Delivery

(2008) Takeshi Suda et al.   MOLECULAR THERAPY

Sleeping Beauty Transposon‐mediated Engineering of Human Primary T Cells for Therapy of CD19+ Lymphoid Malignancies

(2008) Xin Huang et al.   MOLECULAR THERAPY

Transcriptional Activities of the Sleeping Beauty Transposon and Shielding Its Genetic Cargo With Insulators

(2007) Oliver Walisko et al.   MOLECULAR THERAPY

Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications

(2007) Zachary C. Hartman et al.   VIRUS RESEARCH