Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells

Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment

(2020) Stephanie van de Wall et al.   TRENDS IN IMMUNOLOGY

Biological Functions and Analytical Strategies of Sialic Acids in Tumor

(2020) Xiaoman Zhou et al.   Cells

CD226hiCD8+ T Cells Are a Prerequisite for Anti-TIGIT Immunotherapy

(2020) Hyung-seung Jin et al.   Cancer Immunology Research

The regulatory ZFAS1/miR-150/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K/Akt pathway in T-cell acute lymphoblastic leukemia

(2019) Qianqian Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

(2019) Fiona M. Behan et al.   NATURE

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

(2019) Maurice Labuhn et al.   CANCER CELL

Evaluation of ERK as a therapeutic target in acute myelogenous leukemia

(2019) Ellen Weisberg et al.   LEUKEMIA

Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death

(2018) Colleen M. Britain et al.   Journal of Ovarian Research

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

(2018) Shao Thing Teoh et al.   Frontiers in Oncology

A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia

(2018) David R. Spiciarich et al.   CANCER RESEARCH

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

(2018) Lenneke A.M. Cornelissen et al.   INTERNATIONAL JOURNAL OF CANCER

CD34+CD38− leukemic stem cell frequency to predict outcome in acute myeloid leukemia

(2018) Wendelien Zeijlemaker et al.   LEUKEMIA

BCL3 Expression Is a Potential Prognostic and Predictive Biomarker in Acute Myeloid Leukemia of FAB Subtype M2

(2018) Yuna Niu et al.   PATHOLOGY & ONCOLOGY RESEARCH

Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells

(2018) Elizabeth M O'Day et al.   OncoTargets and Therapy

Sialylation is involved in cell fate decision during development, reprogramming and cancer progression

(2018) Fenjie Li et al.   Protein & Cell

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

(2017) Chun-Qing Song et al.   GASTROENTEROLOGY

The Glycosyltransferase ST6Gal-I Protects Tumor Cells against Serum Growth Factor Withdrawal by Enhancing Survival Signaling and Proliferative Potential

(2017) Colleen M. Britain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

(2017) Traver Hart et al.   G3-Genes Genomes Genetics

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity

(2016) Rebecca A. Kohnz et al.   ACS Chemical Biology

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

(2016) K Watanabe-Smith et al.   LEUKEMIA

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies

(2016) Stephanie Weng et al.   Oncotarget

Mutations in AML: prognostic and therapeutic implications

(2016) C. D. DiNardo et al.   Hematology-American Society of Hematology Education Program

Protein Glycosylation in Cancer

(2015) Sean R. Stowell et al.   Annual Review of Pathology-Mechanisms of Disease

A Phase I/II Study of the Janus Kinase (JAK)1 and 2 Inhibitor Ruxolitinib in Patients With Relapsed or Refractory Acute Myeloid Leukemia

(2015) Naveen Pemmaraju et al.   Clinical Lymphoma Myeloma & Leukemia

N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes

(2015) Karol Kaszuba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

(2015) Hsin-Yung Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting RTK Signaling Pathways in Cancer

(2015) Tarik Regad   Cancers

Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal  -dystroglycan O-mannosylation, independent from sialic acid

(2015) M. Riemersma et al.   HUMAN MOLECULAR GENETICS

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia

(2014) H Ma et al.   ONCOGENE

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Sialic acid metabolism and sialyltransferases: natural functions and applications

(2012) Yanhong Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells

(2012) Jung-Jin Park et al.   BIOCHEMICAL PHARMACOLOGY

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Ruxolitinib: The First FDA Approved Therapy for the Treatment of Myelofibrosis

(2012) J. Mascarenhas et al.   CLINICAL CANCER RESEARCH

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common  -subunit

(2010) M. Perugini et al.   BLOOD

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE