Myristoylation-mediated phase separation of EZH2 compartmentalizes STAT3 to promote lung cancer growth

A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis

(2020) Kun Liao et al.   CANCER RESEARCH

The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development

(2020) Mafalda Loreti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomolecular condensates in cell biology and virology: Phase-separated membraneless organelles (MLOs)

(2020) Pravin B. Sehgal et al.   ANALYTICAL BIOCHEMISTRY

Epigenetic Therapy for Epithelioid Sarcoma

(2020) Scott B. Rothbart et al.   CELL

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

(2020) Yi Lu et al.   NATURE CELL BIOLOGY

Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution

(2020) Thierry Meinnel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

(2020) Wenqing Ren et al.   Nature Communications

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

(2020) Huairui Yuan et al.   CANCER CELL

Protein phase separation: A novel therapy for cancer?

(2020) Wei Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

(2020) Anne Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations

(2020) Brian Tsang et al.   CELL

CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

(2019) Xiphias Ge Zhu et al.   MOLECULAR CELL

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane

(2019) Min Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity

(2019) Jesse Balic et al.   CANCER RESEARCH

Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications

(2019) Zhe Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

(2019) Bartosz Gabryelczyk et al.   Nature Communications

Acetylation within the N- and C-Terminal Domains of Src Regulates Distinct Roles of STAT3-Mediated Tumorigenesis

(2018) Chao Huang et al.   CANCER RESEARCH

STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner

(2018) Shanshan Sun et al.   CLINICAL CANCER RESEARCH

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

(2018) Lixin Wan et al.   MOLECULAR CELL

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

(2018) Benoit Castrec et al.   Nature Chemical Biology

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis

(2018) Stephen D'Amico et al.   GENES & DEVELOPMENT

Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics

(2018) Mario Hofweber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src

(2018) Danislav S. Spassov et al.   Cell Reports

Myristoylation of Src kinase mediates Src-induced and high-fat diet–accelerated prostate tumor progression in mice

(2017) Sungjin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus

(2016) Michal Doležal et al.   Retrovirology

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

(2016) Alexei Brooun et al.   Nature Communications

Chromatin topology is coupled to Polycomb group protein subnuclear organization

(2016) Ajazul H. Wani et al.   Nature Communications

Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations

(2015) E. Riquelme et al.   CANCER RESEARCH

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Identification of Human N-Myristoylated Proteins from Human Complementary DNA Resources by Cell-Free and Cellular Metabolic Labeling Analyses

(2015) Emi Takamitsu et al.   PLoS One

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization

(2015) S. Kumar et al.   Biology Open

Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor

(2014) Meng Wu et al.   CELL CYCLE

GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis

(2014) Yangmeng Wang et al.   MOLECULAR CELL

Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy

(2014) Andrea Cerase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promote s NSCLC cell proliferation and metastasis by affecting the epithelial–mesenchymal transition

(2014) M Sun et al.   Cell Death & Disease

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

(2014) Emmanuelle Thinon et al.   Nature Communications

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

High-throughput profiling ofN-myristoylation substrate specificity across species including pathogens

(2012) José A. Traverso et al.   PROTEOMICS

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Repression of Transcription by WT1-BASP1 Requires the Myristoylation of BASP1 and the PIP2-Dependent Recruitment of Histone Deacetylase

(2012) Eneda Toska et al.   Cell Reports

Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm

(2011) Anthony A. Hyman et al.   DEVELOPMENTAL CELL

Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering

(2011) Ariel Erijman et al.   JOURNAL OF STRUCTURAL BIOLOGY

JAK1 Activates STAT3 Activity in Non-Small-Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling

(2011) L. Song et al.   MOLECULAR CANCER THERAPEUTICS

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells

(2010) Sarah Yoon et al.   Autophagy

The consensus motif for N-myristoylation of plant proteins in a wheat germ cell-free translation system

(2010) Seiji Yamauchi et al.   FEBS Journal

Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

(2009) Angela Sing et al.   CELL

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

(2009) I. Sato et al.   JOURNAL OF CELL SCIENCE