Metalloproteinase production from macrophages - a perfect storm leading to atherosclerotic plaque rupture and myocardial infarction

Molecular control of activation and priming in macrophages

(2016) Christopher K Glass et al.   NATURE IMMUNOLOGY

Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice

(2016) Aikaterini Tsaousi et al.   PLoS One

Interleukin-6: Biology, signaling and strategies of blockade

(2015) Fred Schaper et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cytokine-induced monocyte MMP-1 is negatively regulated by GSK-3 through a p38 MAPK-mediated decrease in ERK1/2 MAPK activation

(2015) Yahong Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation

(2015) Andrew C. Newby   MATRIX BIOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Putative targeting of matrix metalloproteinase-8 in atherosclerosis

(2015) Shu Ye   PHARMACOLOGY & THERAPEUTICS

TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages

(2015) Malak Haidar et al.   Scientific Reports

Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype

(2015) Anita C. Thomas et al.   PLoS One

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

(2014) Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

MicroRNA-24 Regulates Macrophage Behavior and Retards Atherosclerosis

(2014) Karina Di Gregoli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

(2014) Jason L. Johnson et al.   MEDIATORS OF INFLAMMATION

A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach

(2014) Matthew Traylor et al.   PLoS Genetics

Classical and Alternative Activation and Metalloproteinase Expression Occurs in Foam Cell Macrophages in Male and Female ApoE Null Mice in the Absence of T and B Lymphocytes

(2014) Elaine Mo Hayes et al.   Frontiers in Immunology

IL-6-Mediated Induction of Matrix Metalloproteinase-9 Is Modulated by JAK-Dependent IL-10 Expression in Macrophages

(2013) P. Kothari et al.   JOURNAL OF IMMUNOLOGY

Membrane-type matrix metalloproteinases: key mediators of leukocyte function

(2013) Marta Marco et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy

(2013) Peter Libby   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage Migration and Invasion Is Regulated by MMP10 Expression

(2013) Megan Y. Murray et al.   PLoS One

Carotid Atherosclerotic Plaque Matrix Metalloproteinase‐12–Positive Macrophage Subpopulation Predicts Adverse Outcome After Endarterectomy

(2013) Vincent P. W. Scholtes et al.   Journal of the American Heart Association

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Smooth Muscle Cell Plasticity

(2012) Anh T. Nguyen et al.   CIRCULATION RESEARCH

Matrix Metalloproteinase-28 Deletion Exacerbates Cardiac Dysfunction and Rupture After Myocardial Infarction in Mice by Inhibiting M2 Macrophage Activation

(2012) Yonggang Ma et al.   CIRCULATION RESEARCH

Role of colony-stimulating factors in atherosclerosis

(2012) Karina Di Gregoli et al.   CURRENT OPINION IN LIPIDOLOGY

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

(2012) Sophie E. Broughton et al.   IMMUNOLOGICAL REVIEWS

Matrix Metalloproteinase-Dependent Microsomal Prostaglandin E Synthase-1 Expression in Macrophages: Role of TNF-  and the EP4 Prostanoid Receptor

(2012) K. M. F. Khan et al.   JOURNAL OF IMMUNOLOGY

LPS Counter Regulates RNA Expression of Extracellular Proteases and Their Inhibitors in Murine Macrophages

(2012) Andreas Hald et al.   MEDIATORS OF INFLAMMATION

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB

(2012) Wei-Chun Huang et al.   PLoS One

Matrix metalloproteinase inhibition therapy for vascular diseases

(2012) Andrew C. Newby   VASCULAR PHARMACOLOGY

Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atherosclerosis

(2011) Thibaut Quillard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apolipoprotein E–Knockout Mice

(2011) Jason L. Johnson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diverse patterns of cyclooxygenase-independent metalloproteinase gene regulation in human monocytes

(2011) Buket Reel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Innate immune recognition receptors and damage-associated molecular patterns in plaque inflammation

(2011) Anna M. Lundberg et al.   CURRENT OPINION IN LIPIDOLOGY

Collagenase matrix metalloproteinase-8 expressed in atherosclerotic carotid plaques is associated with systemic cardiovascular outcome

(2011) Wouter Peeters et al.   EUROPEAN HEART JOURNAL

Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice

(2011) Mizuho Nosaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages

(2011) Young-Jun Shim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

(2011) Muredach P Reilly et al.   LANCET

Hypoxia differentially affects IL-1 -stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1 -dependent manner

(2011) Y.-A. Lee et al.   RHEUMATOLOGY

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

(2010) Ross Vlahos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP-1 and MMP-9 in human macrophages in vitro

(2010) Walter S. Speidl et al.   FASEB JOURNAL

The effects of TGF-β1 on the expression of type IV collagenases in mouse peritoneal macrophages

(2010) Kenji Ogawa et al.   MOLECULAR BIOLOGY REPORTS

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

T-Cell Activation Leads to Reduced Collagen Maturation in Atherosclerotic Plaques of Apoe−/− Mice

(2009) Olga Ovchinnikova et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Toll-Like Receptor-2 Mediates Inflammation and Matrix Degradation in Human Atherosclerosis

(2009) Claudia Monaco et al.   CIRCULATION

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Matrix Metalloproteinase-1 Is Regulated in Tuberculosis by a p38 MAPK-Dependent, p-Aminosalicylic Acid-Sensitive Signaling Cascade

(2009) L. Rand et al.   JOURNAL OF IMMUNOLOGY

Matrix Metalloproteinase (MMP)-1 and MMP-3 Induce Macrophage MMP-9: Evidence for the Role of TNF-  and Cyclooxygenase-2

(2009) M. Steenport et al.   JOURNAL OF IMMUNOLOGY

Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages

(2008) Jason L. Johnson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

(2008) Andrew C. Newby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility

(2008) Nancy Gerits et al.   CELLULAR SIGNALLING

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages

(2008) Imen Jguirim Souissi et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

(2008) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cyclophilin A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid arthritis

(2008) Y. Yang et al.   RHEUMATOLOGY

The regulation of matrix metalloproteinases and their inhibitors

(2007) I CLARK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY