The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

The IL-3/IL-5/GM-CSF Common   Receptor Plays a Pivotal Role in the Regulation of Th2 Immunity and Allergic Airway Inflammation

(2014) K. L. Asquith et al.   JOURNAL OF IMMUNOLOGY

Cytokine receptor activation at the cell surface

(2012) Sophie E Broughton et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The GM-CSF receptor family: Mechanism of activation and implications for disease

(2012) Timothy R. Hercus et al.   GROWTH FACTORS

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Structural basis of interleukin-5 dimer recognition by its α receptor

(2012) Seisuke Kusano et al.   PROTEIN SCIENCE

Murine Interleukin-3: Structure, Dynamics, and Conformational Heterogeneity in Solution

(2011) Shenggen Yao et al.   BIOCHEMISTRY

Long-term follow-up and treatment of congenital alveolar proteinosis

(2011) Matthias Griese et al.   BMC Pediatrics

Beneficial effects of carbamylated erythropoeitin on trauma-induced brain edema: Proposed molecular mechanisms of action*

(2011) David Bar-Or et al.   CRITICAL CARE MEDICINE

Defective Leukocyte GM-CSF Receptor (CD116) Expression and Function in Inflammatory Bowel Disease

(2011) Jonathan I. Goldstein et al.   GASTROENTEROLOGY

β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase

(2011) Kuo-Hui Su et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Src-Like Adaptor Protein Regulates GM-CSFR Signaling and Monocytic Dendritic Cell Maturation

(2011) L. M. Liontos et al.   JOURNAL OF IMMUNOLOGY

Granulocyte Macrophage-Colony-stimulating Factor Autoantibodies and Increased Intestinal Permeability in Crohn Disease

(2011) Cade M Nylund et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Erythropoietin: A Hormone with Multiple Functions

(2011) Matilde Lombardero et al.   PATHOBIOLOGY

Complex interactions in EML cell stimulation by stem cell factor and IL-3

(2011) Z.-j. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

(2011) Patrick J. Lupardus et al.   STRUCTURE

Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Rα

(2011) Edwin Patino et al.   STRUCTURE

Hereditary Pulmonary Alveolar Proteinosis

(2010) Takuji Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Ig-like domain of human GM-CSF receptor α plays a critical role in cytokine binding and receptor activation

(2010) Shamaruh Mirza et al.   BIOCHEMICAL JOURNAL

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common  -subunit

(2010) M. Perugini et al.   BLOOD

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations

(2010) T. Suzuki et al.   EUROPEAN RESPIRATORY JOURNAL

Purified Hematopoietic Stem Cell Transplantation: The Next Generation of Blood and Immune Replacement

(2010) Agnieszka Czechowicz et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Molecular basis of cytokine receptor activation

(2010) Angel F Lopez et al.   IUBMB LIFE

Two Modes of β-Receptor Recognition Are Mediated by Distinct Epitopes on Mouse and Human Interleukin-3

(2010) Shamaruh Mirza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB

(2010) T. Tanaka et al.   JOURNAL OF MEDICAL GENETICS

Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis

(2010) B Uberti et al.   ONCOGENE

Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2

(2010) Patrick J. Lupardus et al.   STRUCTURE

Hematopoietic stem cell: self-renewal versus differentiation

(2010) Jun Seita et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

(2009) J. A. Powell et al.   BLOOD

Induction of nitric oxide by erythropoietin is mediated by the   common receptor and requires interaction with VEGF receptor 2

(2009) L. Sautina et al.   BLOOD

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

(2009) T. R. Hercus et al.   BLOOD

Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation

(2009) Ernestina Saulle et al.   BRITISH JOURNAL OF HAEMATOLOGY

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

(2009) Liqing Jin et al.   Cell Stem Cell

Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3

(2009) S. Kim et al.   JOURNAL OF IMMUNOLOGY

Human Basophils Secrete IL-3: Evidence of Autocrine Priming for Phenotypic and Functional Responses in Allergic Disease

(2009) J. T. Schroeder et al.   JOURNAL OF IMMUNOLOGY

MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity

(2009) Jacqueline G Perrigoue et al.   NATURE IMMUNOLOGY

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

Anti–Interleukin-5 Therapy and Severe Asthma

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Cytokine–Cytokine Interaction in the Assembly of Higher-Order Structure and Activation of the Interleukine-3:Receptor Complex

(2009) Raja Dey et al.   PLoS One

Characteristics of a Large Cohort of Patients with Autoimmune Pulmonary Alveolar Proteinosis in Japan

(2008) Yoshikazu Inoue et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

(2008) C. S. Bonder et al.   BLOOD

IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

(2008) S. A. Didichenko et al.   BLOOD

Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus

(2008) F.D. Lourenço et al.   BRITISH JOURNAL OF DERMATOLOGY

Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS-related tyrosine kinase 3 receptor

(2008) Roberta Riccioni et al.   BRITISH JOURNAL OF HAEMATOLOGY

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

(2008) Nikesh Kotecha et al.   CANCER CELL

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Slow-dissociation effect of common signaling subunit β on IL5 and GM-CSF receptor assembly

(2008) Tetsuya Ishino et al.   CYTOKINE

A New Isoform of Interleukin-3 Receptor α with Novel Differentiation Activity and High Affinity Binding Mode

(2008) Jinglong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-5 Receptor Subunit Oligomerization and Rearrangement Revealed by Fluorescence Resonance Energy Transfer Imaging

(2008) Meirav Zaks-Zilberman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Familial pulmonary alveolar proteinosis caused by mutations inCSF2RA

(2008) Takuji Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

(2008) Shigeaki Hida et al.   NATURE IMMUNOLOGY

Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab

(2008) Marc E. Rothenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

(2008) M. Brines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA