Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition

Inhibitors of diacylglycerol metabolism suppress CCR2 receptor signalling in human monocytes

(2019) P. Day et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.

(2019) Wendy A. Williams et al.   PAIN

Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

(2019) Anfal Bin Dayel et al.   MOLECULAR PHARMACOLOGY

ATP-Evoked Intracellular Ca2+ Responses in M-CSF Differentiated Human Monocyte-Derived Macrophage are Mediated by P2X4 and P2Y11 Receptor Activation

(2019) Janice A. Layhadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

(2018) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ginsenosides Act As Positive Modulators of P2X4 Receptors

(2018) Kshitija Dhuna et al.   MOLECULAR PHARMACOLOGY

Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor

(2018) Claudio Coddou et al.   NEUROSCIENCE LETTERS

P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages

(2017) Janice Layhadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATP Evokes Ca2+Responses and CXCL5 Secretion via P2X4Receptor Activation in Human Monocyte-Derived Macrophages

(2017) Janice A. Layhadi et al.   JOURNAL OF IMMUNOLOGY

Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin

(2017) I-Shan Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation

(2017) Verónica Latapiat et al.   Frontiers in Pharmacology

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

(2017) Leanne Stokes et al.   Frontiers in Pharmacology

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

(2016) Tomohiro Yamashita et al.   PLoS One

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

(2016) Yuta Matsumura et al.   Scientific Reports

Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals

(2015) Jessica C. Nicholson-Fish et al.   NEUROCHEMICAL RESEARCH

Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin

(2015) Chao Gao et al.   Purinergic Signalling

Novel Protective Role of Endogenous Cardiac Myocyte P2X4 Receptors in Heart Failure

(2014) Tiehong Yang et al.   Circulation-Heart Failure

Novel Regulation of CD80/CD86-induced Phosphatidylinositol 3-Kinase Signaling by NOTCH1 Protein in Interleukin-6 and Indoleamine 2,3-Dioxygenase Production by Dendritic Cells

(2014) Chandana Koorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

Carbamazepine derivatives with P2X4 receptor-blocking activity

(2013) Maoqun Tian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-Substituted Phenoxazine and Acridone Derivatives: Structure–Activity Relationships of Potent P2X4 Receptor Antagonists

(2012) Victor Hernandez-Olmos et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dual Polybasic Motif Determines Phosphoinositide Binding and Regulation in the P2X Channel Family

(2012) Louis-Philippe Bernier et al.   PLoS One

Rab5 regulates internalisation of P2X4 receptors and potentiation by ivermectin

(2012) Leanne Stokes   Purinergic Signalling

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

(2011) Knut Biber et al.   EMBO JOURNAL

Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes

(2011) P. Miklavc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin

(2010) Estelle Toulme et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells

(2009) K Wareham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidepressants Inhibit P2X4 Receptor Function: a Possible Involvement in Neuropathic Pain Relief

(2009) Kenichiro Nagata et al.   Molecular Pain

Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

(2009) Walid Fayad et al.   PLoS One

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions

(2008) L.-P. Bernier et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2α on Neurosecretory Vesicles

(2008) Peter J. Wen et al.   MOLECULAR BIOLOGY OF THE CELL

Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways

(2007) Jing Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Dragon's blood: Botany, chemistry and therapeutic uses

(2007) Deepika Gupta et al.   JOURNAL OF ETHNOPHARMACOLOGY

HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice

(2007) Wen Lu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS