P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation
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Title
P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-12-15
DOI
10.3389/fphar.2017.00918
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Note: Only part of the references are listed.- Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models
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- Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin
- (2015) Chao Gao et al. Purinergic Signalling
- Allosteric regulation of the P2X4 receptor channel pore dilation
- (2014) Hana Zemkova et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors
- (2013) Maya Popova et al. Purinergic Signalling
- Allosteric Modulation of Ca2+flux in Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals
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- Molecular mechanism of ATP binding and ion channel activation in P2X receptors
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- Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
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- Moving through the gate in ATP-activated P2X receptors
- (2012) Ruotian Jiang et al. TRENDS IN BIOCHEMICAL SCIENCES
- Ion access pathway to the transmembrane pore in P2X receptor channels
- (2011) Toshimitsu Kawate et al. JOURNAL OF GENERAL PHYSIOLOGY
- Principles of activation and permeation in an anion-selective Cys-loop receptor
- (2011) Ryan E. Hibbs et al. NATURE
- Activation and Regulation of Purinergic P2X Receptor Channels
- (2011) C. Coddou et al. PHARMACOLOGICAL REVIEWS
- Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)
- (2011) D. S. K. Samways et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- CHARMM: The biomolecular simulation program
- (2009) B. R. Brooks et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Crystal structure of the ATP-gated P2X4 ion channel in the closed state
- (2009) Toshimitsu Kawate et al. NATURE
- Identification of P2X4 receptor transmembrane residues contributing to channel gating and interaction with ivermectin
- (2008) Irena Jelínkova et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
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