A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Medicinal chemistry of adenosine, P2Y and P2X receptors

(2016) Kenneth A. Jacobson et al.   NEUROPHARMACOLOGY

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Involvement of the Chemokine CCL3 and the Purinoceptor P2×7 in the Spinal Cord in Paclitaxel-Induced Mechanical Allodynia

(2014) Ryutaro Ochi-Ishi et al.   Molecular Pain

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

(2014) Gergely Horváth et al.   NEUROBIOLOGY OF DISEASE

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4Purinergic Receptors by two Complementary Methods

(2013) Bernadett Balázs et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

N-Substituted Phenoxazine and Acridone Derivatives: Structure–Activity Relationships of Potent P2X4 Receptor Antagonists

(2012) Victor Hernandez-Olmos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Involvement of Tyr1472 Phosphorylation of NMDA Receptor NR2B Subunit in Postherpetic Neuralgia in Model Mice

(2012) Sawako Unezaki et al.   Molecular Pain

P2X4R+ microglia drive neuropathic pain

(2012) Simon Beggs et al.   NATURE NEUROSCIENCE

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

(2012) Emika Toyomitsu et al.   Purinergic Signalling

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

(2011) Kimiko Kobayashi et al.   NEUROSCIENCE LETTERS

Contribution of spinal galectin-3 to acute herpetic allodynia in mice

(2011) Ichiro Takasaki et al.   PAIN

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Antidepressants Inhibit P2X4 Receptor Function: a Possible Involvement in Neuropathic Pain Relief

(2009) Kenichiro Nagata et al.   Molecular Pain

Behavioral Phenotypes of Mice Lacking Purinergic P2X4 Receptors in Acute and Chronic Pain Assays

(2009) Makoto Tsuda et al.   Molecular Pain

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Differences Between Static and Dynamic Allodynia in Mice With Herpetic or Postherpetic Pain

(2008) Atsushi Sasaki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY