Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3‐mediated muscle wasting in cancer cachexia mice

ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020

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HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting

(2019) Souad Mubaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

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(2018) Steve P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

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(2018) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells

(2018) Kisho Ono et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Modulating Metabolism to Improve Cancer-Induced Muscle Wasting

(2018) Fabio Penna et al.   Oxidative Medicine and Cellular Longevity

STAT3 in Skeletal Muscle Function and Disorders

(2018) Eleonora Guadagnin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy

(2018) Brian T. O’Neill et al.   DIABETES

S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation

(2018) Shiyu Song et al.   EBioMedicine

The HSP90 chaperone machinery

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

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Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

(2017) Shiyu Song et al.   Cell Death & Disease

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response

(2017) Dunwei Guo et al.   Oncotarget

The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation

(2016) Philippe A. Bilodeau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

STAT3 in the systemic inflammation of cancer cachexia

(2016) Teresa A. Zimmers et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

(2015) Kleiton Augusto Santos Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

(2015) Francesca Pretto et al.   Oncotarget

Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

(2014) Y. S. Gallot et al.   CANCER RESEARCH

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

(2013) Liping Zhang et al.   Cell Metabolism

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

Selective androgen receptor modulators in cancer cachexia?

(2013) Kenneth H Fearon   LANCET ONCOLOGY

HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise

(2013) Bong-Sup Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes

(2012) F. Mashili et al.   DIABETES

STAT3 interacts directly with Hsp90

(2012) Earl Prinsloo et al.   IUBMB LIFE

Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins

(2011) Sudarsanareddy Lokireddy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

(2011) Sarah A. Reed et al.   FASEB JOURNAL

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells

(2009) Nils Schoof et al.   Cell Communication and Signaling

Interleukin-6 and cachexia in ApcMin/+ mice

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