A versatile toolbox for investigating biological processes based on quinone methide chemistry: From self-immolative linkers to self-immobilizing agents

γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging

(2020) Rui Obara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quinone Methide‐Based Organophosphate Hydrolases Inhibitors: Trans Proximity Labelers versus Cis Labeling Activity‐Based Probes

(2020) Artem Dubovetskyi et al.   CHEMBIOCHEM

Activity-Based Optical Sensing Enabled by Self-Immolative Scaffolds: Monitoring of Release Events by Fluorescence or Chemiluminescence Output

(2019) Samer Gnaim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Activatable Photosensitizer for Targeted Ablation of lacZ-Positive Cells with Single-Cell Resolution

(2019) Mayumi Chiba et al.   ACS Central Science

A novel sialidase-activatable fluorescence probe with improved stability for the sensitive detection of sialidase

(2019) Charlotte Rivas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuraminidase-triggered activation of prodrug-type substrate of 4-nitroaniline

(2019) Takahiko Matsushita et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of highly sensitive fluorescent probes for the detection of β-galactosidase activity – application to the real-time monitoring of senescence in live cells

(2018) Mauro Safir Filho et al.   ANALYST

Direct Real-Time Monitoring of Prodrug Activation by Chemiluminescence

(2018) Samer Gnaim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The emergence of aqueous chemiluminescence: new promising class of phenoxy 1,2-dioxetane luminophores

(2018) Samer Gnaim et al.   CHEMICAL COMMUNICATIONS

Proximity labeling: spatially resolved proteomic mapping for neurobiology

(2018) Shuo Han et al.   CURRENT OPINION IN NEUROBIOLOGY

Red-shifted fluorogenic substrate for detecting lacZ-positive cells in living tissue with single-cell resolution

(2018) Hiroki Ito et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

(2018) Hong-Wen Liu et al.   CHEMICAL SOCIETY REVIEWS

Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors

(2018) Jiatao Yan et al.   CHEMICAL SOCIETY REVIEWS

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

Self-Immolative Chemiluminescence Polymers: Innate Assimilation of Chemiexcitation in a Domino-like Depolymerization

(2017) Samer Gnaim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes

(2017) Ori Green et al.   ACS Central Science

Detection of LacZ -Positive Cells in Living Tissue with Single-Cell Resolution

(2016) Tomohiro Doura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Hexosaminidase-Targeting Fluorescence Probe for Visualizing Human Colorectal Cancer

(2016) Hiroyuki Matsuzaki et al.   BIOCONJUGATE CHEMISTRY

Self-Immolative Spacers: Kinetic Aspects, Structure-Property Relationships, and Applications

(2015) Ahmed Alouane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Human α-L-Fucosidases by a Quinone Methide-Generating Probe: Enhanced Activities in Response toHelicobacter pyloriInfection

(2015) Manjula Nandakumar et al.   CHEMBIOCHEM

An enzyme-activatable probe with a self-immolative linker for rapid and sensitive alkaline phosphatase detection and cell imaging through a cascade reaction

(2015) Hongmei Zhang et al.   CHEMICAL COMMUNICATIONS

NIR Fluorogenic Dye as a Modular Platform for Prodrug Assembly: Real-Time in vivo Monitoring of Drug Release

(2015) Orit Redy-Keisar et al.   ChemMedChem

A Pilot Study of Fluorescent Imaging of Colorectal Tumors Using a γ-Glutamyl-Transpeptidase-Activatable Fluorescent Probe

(2015) Chiko Sato et al.   DIGESTION

Chemiluminescent probes for imaging H2S in living animals

(2015) J. Cao et al.   Chemical Science

Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo

(2015) Daisuke Asanuma et al.   Nature Communications

Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green

(2015) Hiroki Ueo et al.   Scientific Reports

Quinone-Methide Species, A Gateway to Functional Molecular Systems: From Self-Immolative Dendrimers to Long-Wavelength Fluorescent Dyes

(2014) Samer Gnaim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Selective Ablation of β-Galactosidase-Expressing Cells with a Rationally Designed Activatable Photosensitizer

(2014) Yuki Ichikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Activatable Prodrug for the Treatment of Metastatic Tumors

(2014) Eun-Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemiluminescence Sensing of Fluoride Ions Using a Self-Immolative Amplifier

(2014) Ilke Simsek Turan et al.   ORGANIC LETTERS

Fluorescence-activated cell sorting and directed evolution of α-N-acetylgalactosaminidases using a quenched activity-based probe (qABP)

(2013) Kamaladasan Kalidasan et al.   CHEMICAL COMMUNICATIONS

Effects of Electronics, Aromaticity, and Solvent Polarity on the Rate of Azaquinone–Methide-Mediated Depolymerization of Aromatic Carbamate Oligomers

(2013) Jessica S. Robbins et al.   JOURNAL OF ORGANIC CHEMISTRY

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe

(2012) Makoto Mitsunaga et al.   GUT

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

A Self-Immolative Spacer That Enables Tunable Controlled Release of Phenols under Neutral Conditions

(2012) Kyle M. Schmid et al.   JOURNAL OF ORGANIC CHEMISTRY

Multicolor, One- and Two-Photon Imaging of Enzymatic Activities in Live Cells with Fluorescently Quenched Activity-Based Probes (qABPs)

(2011) Mingyu Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Galactosidase Fluorescence Probe with Improved Cellular Accumulation Based on a Spirocyclized Rhodol Scaffold

(2011) Mako Kamiya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cancer Detection by Topically Spraying a  -Glutamyltranspeptidase-Activated Fluorescent Probe

(2011) Y. Urano et al.   Science Translational Medicine

Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity

(2010) David H. Kwan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-Linked Labeling of Enzymes by Self-Immolative Polymers

(2009) Roy Weinstain et al.   BIOCONJUGATE CHEMISTRY

Enzymatic activation of hydrophobic self-immolative dendrimers: The effect of reporters with ionizable functional groups

(2009) Michal Avital-Shmilovici et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple Pathways for the Irreversible Inhibition of Steroid Sulfatase with Quinone Methide-Generating Suicide Inhibitors

(2009) Vanessa Ahmed et al.   CHEMBIOCHEM

Real-time monitoring of drug release

(2009) Roy Weinstain et al.   CHEMICAL COMMUNICATIONS

Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs)

(2009) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

Activity-Based Proteome Profiling of Hepatoma Cells during Hepatitis C Virus Replication Using Protease Substrate Probes

(2009) David R. Blais et al.   JOURNAL OF PROTEOME RESEARCH

Latent Fluorophores Based on a Self-Immolative Linker Strategy and Suitable for Protease Sensing†

(2008) Jean-Alexandre Richard et al.   BIOCONJUGATE CHEMISTRY

A design concept of long-wavelength fluorescent analogs of rhodamine dyes: replacement of oxygen with silicon atom

(2008) Meiyan Fu et al.   CHEMICAL COMMUNICATIONS

Self-Immolative Polymers

(2008) Amit Sagi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The azaquinone-methide elimination: comparison study of 1,6- and 1,4-eliminations under physiological conditions

(2008) Rotem Erez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY