Developments of small molecules as inhibitors for carbonic anhydrase isoforms

Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes

(2020) Cem Yamali et al.   BIOORGANIC CHEMISTRY

Synthesis of some N-aroyl-2-oxindole benzenesulfonamide conjugates with carbonic anhydrase inhibitory activity

(2020) Riham F. George et al.   BIOORGANIC CHEMISTRY

5‐[2‐(N‐(substituted phenyl) acetamide)] amino‐1, 3, 4‐thiadiazole ‐2‐sulfonamides as selective carbonic anhydrase II inhibitor with neuroprotective effects

(2020) jingxia zhang et al.   ChemMedChem

Synthesis and structure–affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors

(2020) Benas Balandis et al.   BIOORGANIC CHEMISTRY

Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors

(2019) Vikas Sharma et al.   BIOORGANIC CHEMISTRY

Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity

(2019) Wagdy M. Eldehna et al.   BIOORGANIC CHEMISTRY

From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction

(2019) Stanislav Kalinin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors

(2019) Azize Gizem Uslu et al.   BIOORGANIC CHEMISTRY

Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors

(2019) Lalit Vats et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies

(2019) Belma Zengin Kurt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of carbohydrate-based sulphonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II

(2019) Zhuang Hou et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications

(2018) Alexei Medvedev et al.   BIOFACTORS

Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform

(2018) Hany S. Ibrahim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors

(2018) Lalit Vats et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of pyrazolo[3,4- d ]pyrimidin-4(5 H )-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents

(2018) Muralidhar Allam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII

(2018) Alessandro Bonardi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors

(2018) Rajiv Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sulfonamide inhibitors: a patent review 2013-present

(2018) İlhami Gulçin et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

(2018) Fadi M. Awadallah et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

(2018) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

(2018) Claudiu T. Supuran et al.   MEDICINAL RESEARCH REVIEWS

Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

(2018) Mahmoud F. Abo-Ashour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases

(2018) Irena Vaškevičienė et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety

(2018) Maria Rosa Buemi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity

(2018) Hanan H. Georgey et al.   BIOORGANIC CHEMISTRY

Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies

(2017) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase XII functions in health and disease

(2017) Abdul Waheed et al.   GENE

Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity

(2017) Rajiv Kumar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines

(2016) Nagwa M. Abdel Gawad et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Accurately Determining Esterase Activity via the Isosbestic Point of p-Nitrophenol

(2016) Yangyang Peng et al.   BioResources

Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents

(2016) Sai-Yang Zhang et al.   MOLECULES

Methods for the synthesis of 1-substituted 1H-imidazol-2(3H)-ones

(2015) Maria M. Antonova et al.   Chemistry of Heterocyclic Compounds

Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives

(2015) Fadi M. Awadallah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A click chemistry approach for the synthesis of mono and bis aryloxy linked coumarinyl triazoles as anti-tubercular agents

(2015) Ashish Anand et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Probing the ‘bipolar’ nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms

(2015) Mikhail Krasavin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII

(2015) Hany S. Ibrahim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

(2015) Özlen Güzel-Akdemir et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A novel high performance stopped-flow apparatus equipped with a special constructed mixing chamber containing a plunger under inert condition with a very short dead-time to investigate very rapid reactions

(2015) Sayyed Mostafa Habibi Khorassani et al.   Arabian Journal of Chemistry

Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties

(2014) Cenzo Congiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents

(2014) Li-Ying Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioavailability, tissue distribution and excretion characteristics of the novel carbonic anhydrase inhibitor tolsultazolamide in rats

(2013) Jin-da Wang et al.   ACTA PHARMACOLOGICA SINICA

The Application of Transient-State Kinetic Isotope Effects to the Resolution of Mechanisms of Enzyme-Catalyzed Reactions

(2013) Harvey Fisher   MOLECULES

Azastilbenes: a cut-off to p38 MAPK inhibitors

(2013) Jia-Fei Poon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient synthesis and in vitro antifungal activity of 1H-benzimidazol-1-yl acetates/propionates containing 1H-1,2,4-triazole moiety

(2012) Pei Zhi Zhang et al.   CHINESE CHEMICAL LETTERS

A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions

(2012) Qiuhua Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)

(2012) Mayank Aggarwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

(2011) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

(2011) Arjun Raghuraman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies

(2010) Cemalettin Alp et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anticancer activity of chromone-based analogs of lavendustin A

(2010) Dong Hyuk Nam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode α-carbonic anhydrases

(2009) Letizia Crocetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclic Anhydrides in Formal Cycloadditions and Multicomponent Reactions

(2009) Marcos González-López et al.   CHEMICAL REVIEWS

Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture

(2009) Alessandro K. Jordão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Titration Calorimetry Standards and the Precision of Isothermal Titration Calorimetry Data

(2009) Lina Baranauskienė et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives

(2008) Frank Wuest et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

(2008) Kazutoshi Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Clubbed [1,2,3] triazoles by fluorine benzimidazole: A novel approach to H37Rv inhibitors as a potential treatment for tuberculosis

(2008) Charansingh Gill et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

(2008) Mika Hilvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Palladium-Catalyzed Carbonylative Cross-Coupling with Imines:  A Multicomponent Synthesis of Imidazolones

(2007) Ali R. Siamaki et al.   JOURNAL OF ORGANIC CHEMISTRY