Uncovering the pharmacological mechanisms of Xijiao Dihuang decoction combined with Yinqiao powder in treating influenza viral pneumonia by an integrative pharmacology strategy

Integrated strategy for accurately screening biomarkers based on metabolomics coupled with network pharmacology

(2020) Wendan Zhang et al.   TALANTA

Severity and outcomes of influenza-related pneumonia in type A and B strains in China, 2013–2019

(2020) Liang Chen et al.   Infectious Diseases of Poverty

Prediction of potential cancer-related molecular targets of North African plants constituents using network pharmacology-based analysis

(2019) Eman Shawky   JOURNAL OF ETHNOPHARMACOLOGY

Bioinformatic and experimental data decipher the pharmacological targets and mechanisms of plumbagin against hepatocellular carcinoma

(2019) Rui Zhou et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction

(2019) Xu-Qin Shi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Uncovering the pharmacological mechanism of Carthamus tinctorius L. on cardiovascular disease by a systems pharmacology approach

(2019) Guohua Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Investigation of the pharmacodynamic substances in dahuang zhechong pill that inhibit energy metabolism

(2019) Zi Hui Ni et al.   JOURNAL OF ETHNOPHARMACOLOGY

Integrating Network Pharmacology and Pharmacological Evaluation for Deciphering the Action Mechanism of Herbal Formula Zuojin Pill in Suppressing Hepatocellular Carcinoma

(2019) Wei Guo et al.   Frontiers in Pharmacology

IL-17 in the lung: the good, the bad, and the ugly

(2018) Stephen J. Gurczynski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hesperidin attenuates influenza A virus (H1N1)-induced lung injury in rats through its anti-inflammatory effect

(2018) Zhen Ding et al.   ANTIVIRAL THERAPY

Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways

(2018) Jean-Bosco Jouda et al.   BIOORGANIC CHEMISTRY

Signaling Pathways in Inflammation and Anti-inflammatory Therapies

(2018) Yiu To Yeung et al.   CURRENT PHARMACEUTICAL DESIGN

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

(2018) Peng Pang et al.   Evidence-based Complementary and Alternative Medicine

Novel effect of methionine enkephalin against influenza A virus infection through inhibiting TLR7-MyD88-TRAF6-NF-κB p65 signaling pathway

(2018) Jing Tian et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways

(2018) Xinyao Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cappariloside A shows antiviral and better anti-inflammatory effects against influenza virus via regulating host IFN signaling, in vitro and vivo

(2018) Zhengtu Li et al.   LIFE SCIENCES

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling

(2018) Keesha E. Erickson et al.   SEMINARS IN CANCER BIOLOGY

Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway

(2018) Haiyan Yan et al.   Virology Journal

Shikonofuran E plays an anti-inflammatory role by down-regulating MAPK and NF-κB signaling pathways in lipopolysaccharide-stimulated RAW264.7 macrophages

(2018) Lang Cao et al.   Journal of Natural Medicines

Deciphering the absorption profile and interaction of multi-components of Zhi-Zi-Da-Huang decoction based on in vitro–in silico–in vivo integrated strategy

(2018) Qing Hu et al.   XENOBIOTICA

Anti-inflammatory effects of Chinese propolis in lipopolysaccharide-stimulated human umbilical vein endothelial cells by suppressing autophagy and MAPK/NF-κB signaling pathway

(2018) Hongzhuan Xuan et al.   INFLAMMOPHARMACOLOGY

Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis

(2018) Guohua Yu et al.   BMC Complementary and Alternative Medicine

Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth

(2018) Feifei Liu et al.   MOLECULAR CARCINOGENESIS

UPLC-QTOF-MSE -based diagnostic product ion filtering to unveil unstable C6 -C2 glucoside conjugates in Forsythia suspensa

(2017) Yong-Gang Xia et al.   JOURNAL OF MASS SPECTROMETRY

Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway

(2017) Ming Wang et al.   PHYTOMEDICINE

TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations

(2017) Run-zhi Zhang et al.   Scientific Reports

A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders

(2017) Yanqiong Zhang et al.   Chinese Medicine

The JNK Signaling Pathway in Renal Fibrosis

(2017) Keren Grynberg et al.   Frontiers in Physiology

Drug resistance in influenza A virus: the epidemiology and management

(2017) Mazhar Hussain et al.   Infection and Drug Resistance

Therapeutic effects of Euphorbia Pekinensis and Glycyrrhiza glabra on Hepatocellular Carcinoma Ascites Partially Via Regulating the Frk-Arhgdib-Inpp5d-Avpr2-Aqp4 Signal Axis

(2017) Yanqiong Zhang et al.   Scientific Reports

Neutrophils releasing IL-17A into NETs are essential to plasma cell differentiation in inflamed tissue dependent on IL-1R

(2016) Lidiane Zito Grund et al.   AUTOIMMUNITY

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure ProgressionNovelty and Significance

(2016) Huan Wang et al.   HYPERTENSION

Naringenin targets ERK2 and suppresses UVB-induced photoaging

(2016) Sung Keun Jung et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma

(2016) Maria I. Toki et al.   Journal of Thoracic Oncology

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling

(2016) Kristin B. Runkle et al.   MOLECULAR CELL

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer

(2016) Do Young Lim et al.   Oncotarget

Pathway of PPAR-gamma coactivators in thermogenesis: a pivotal traditional Chinese medicine-associated target for individualized treatment of rheumatoid arthritis

(2016) Yanqiong Zhang et al.   Oncotarget

Thyroid hormone synthesis: a potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter

(2016) Yanqiong Zhang et al.   Oncotarget

Network pharmacology-based identification of key pharmacological pathways of Yin–Huang–Qing–Fei capsule acting on chronic bronchitis

(2016) Guohua Yu et al.   International Journal of Chronic Obstructive Pulmonary Disease

Deciphering the pharmacological mechanism of the Chinese formula Huanglian-Jie-Du decoction in the treatment of ischemic stroke using a systems biology-based strategy

(2015) Yan-qiong Zhang et al.   ACTA PHARMACOLOGICA SINICA

Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-α/EGFR signaling

(2015) Yoko Ito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Glabridin arrests cell cycle and inhibits proliferation of hepatocellular carcinoma by suppressing braf/MEK signaling pathway

(2015) Ziyou Wang et al.   TUMOR BIOLOGY

EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production

(2014) April Kalinowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation

(2014) Sung Dae Kim et al.   BIOCHEMICAL PHARMACOLOGY

Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy

(2014) John R. Teijaro et al.   VIROLOGY

Ultra-performance LC-ESI/quadrupole-TOF MS for rapid analysis of chemical constituents of Shaoyao-Gancao decoction

(2013) Quanwei Yin et al.   JOURNAL OF SEPARATION SCIENCE

Early Host Responses of Seasonal and Pandemic Influenza A Viruses in Primary Well-Differentiated Human Lung Epithelial Cells

(2013) Rachael L. Gerlach et al.   PLoS One

An integrated exact mass spectrometric strategy for comprehensive and rapid characterization of phenolic compounds in licorice

(2013) Tongtong Xu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

(2013) X. Ding et al.   Science Signaling

Influenza A Induces the Major Secreted Airway Mucin MUC5AC in a Protease–EGFR–Extracellular Regulated Kinase–Sp1–Dependent Pathway

(2012) Diane Barbier et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ras family of small GTPases in immunity and inflammation

(2012) Derek S Johnson et al.   CURRENT OPINION IN PHARMACOLOGY

Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance

(2012) Jennifer L. McKimm-Breschkin   Influenza and Other Respiratory Viruses

Identification and quantification of flavonoids and ellagic acid derivatives in therapeutically important Drosera species by LC–DAD, LC–NMR, NMR, and LC–MS

(2011) Martin Zehl et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

(2011) J. Li et al.   CANCER RESEARCH

Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs

(2011) J. Li et al.   CARCINOGENESIS

In vivo and in vitro antiviral effects of berberine on influenza virus

(2011) Ying Wu et al.   Chinese Journal of Integrative Medicine

Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs

(2011) Francisco J. Azuaje et al.   Scientific Reports

Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells

(2010) Jong-Eun Kim et al.   BRITISH JOURNAL OF NUTRITION

Identification and characterization of five new classes of chlorogenic acids in burdock (Arctium lappa L.) roots by liquid chromatography/tandem mass spectrometry

(2010) Rakesh Jaiswal et al.   Food & Function

NF-κB regulation: the nuclear response

(2009) Arun K. Mankan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription

(2008) Musarat Ishaq et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine

(2008) Ryoko Yumoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES