Article
Chemistry, Medicinal
Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho, Meehyein Kim
Summary: Influenza viruses are major pathogens causing respiratory infections in humans. A newly discovered isoquinolone compound showed potential in inhibiting influenza A and B viruses, but exhibited cytotoxic effects. Through chemical optimization, compound 21 was developed with improved antiviral activity and reduced cytotoxicity.
Article
Medicine, Research & Experimental
Won-Kyung Cho, Jin Yeul Ma
Summary: Epimedium koreanum Nakai (EKN) has shown significant inhibitory effects on influenza A virus infection by directly blocking viral attachment and having a virucidal effect. It can potentially be developed as a natural viral inhibitor against influenza virus infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun Lim, Hoyeon Jeon, In-Gu Lee, Yong -Bin Cho, So-Hee Hong, Eui Ho Kim, Soon Ho Choi, Jung-Woong Kim, Se Chan Kang, Young-Jin Seo
Summary: This study investigated the anti-influenza A virus (IAV) activity of an aqueous mixture of Agrimonia pilosa and Galla rhois extracts (APRG64). The results showed that APRG64 significantly reduced IAV-induced cytopathic effect, viral protein transcription/expression, and infectious viral particle production. The main component responsible for the anti-IAV activity was identified as apigenin. APRG64 and apigenin inhibited virus attachment, entry, and polymerase activity. Intranasal or oral administration of APRG64 reduced viral loads and protected mice from IAV-induced mortality by reducing viral RNA levels and pro-inflammatory cytokine expression in the lungs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Cagla Begum Apaydin, Merve Tansuyu, Zafer Cesur, Lieve Naesens, Fusun Goktas
Summary: A series of novel N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)carboxamides have been synthesized and evaluated as antiviral agents. Some analogues showed activity against H3N2 influenza virus, with compounds 3c and 3d exhibiting the most potent antiviral effects. These findings contribute to the understanding of spirothiazolidinone-based inhibitors of influenza virus membrane fusion.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Hui-Xian Wang, Mao-Sen Zeng, Yi Ye, Jin-Yuan Liu, Pei-Ping Xu
Summary: Puerarin, a major isoflavone compound from Pueraria lobata root, exhibits various properties including anti-inflammatory, antioxidant, and antiviral effects. It shows inhibitory activity against H1N1 influenza virus by blocking viral NP transport and newly formed virus particle release. In vivo studies demonstrate its potential as a treatment for influenza virus infection, with effective antiviral activity and reduced inflammation in the lungs.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Na Jiang, Liqiu Quan, Yan Zhou, Yungyi Cheng, Hongmei Li, Xuanqin Chen, Rongtao Li, Dan Liu
Summary: This study found that TP derivatives have antiviral activity and anti-inflammatory effects against influenza A virus by inhibiting viral replication and regulating immune response. They could be potential candidates for antiviral drugs.
BIOORGANIC CHEMISTRY
(2022)
Review
Virology
Mostafa Javanian, Mohammad Barary, Sam Ghebrehewet, Veerendra Koppolu, VeneelaKrishnaRekha Vasigala, Soheil Ebrahimpour
Summary: Influenza is an acute viral respiratory infection that affects all age groups and is associated with high mortality. Vaccination is the most effective method for prevention, but antiviral drugs are also available for treatment.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Mengwei Li, Yuxu Wang, Jing Jin, Jie Dou, Qinglong Guo, Xue Ke, Changlin Zhou, Min Guo
Summary: The study reveals that honeysuckle acids and flavonoids extracts are the major antiviral active components, showing inhibitory effects against influenza viruses. Honeysuckle extracts have a broad-spectrum inhibitory effect on the neuraminidase of influenza viruses.
Article
Nutrition & Dietetics
Ayaka Nakashima, Yuka Horio, Kengo Suzuki, Yuji Isegawa
Summary: Euglena extract has shown strong inhibitory effects against various strains of influenza virus, including drug-resistant strains. It may work by activating host cell defense mechanisms rather than directly targeting the virus. Additionally, minerals in the extract, mainly zinc, were found to be involved in its antiviral activity.
Article
Virology
Rashid Manzoor, Nao Eguchi, Reiko Yoshida, Hiroichi Ozaki, Tatsunari Kondoh, Kosuke Okuya, Hiroko Miyamoto, Ayato Takada
Summary: Protective immunity against influenza A viruses mainly relies on antibodies to hemagglutinin (HA), but the conserved M2 protein has been studied as a vaccine antigen for cross-protective immunity. This study reveals that an M2-specific antibody can interfere with the HA-M2 association, providing a novel mechanism for the antiviral activity of M2-specific antibodies.
JOURNAL OF VIROLOGY
(2021)
Article
Plant Sciences
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun Lim, Hoyeon Jeon, Eui Ho Kim, Joongyeon Choi, Woojae Hong, Hyelin Jeon, Michael Ahrweiler, Hyunggun Kim, Se Chang Kang, Young-Jin Seo
Summary: The study found that the extract of Elaeocarpus sylvestris has strong antiviral activity against influenza A virus infection, which could lead to the development of new plant-based medicine to treat influenza virus infection.
Article
Virology
Zhenya Wang, Jieyu Fang, Jiao Luo, Duoduo Hou, Yayun Tan, Zichen Gu, Yongzhuang Ge, Lu Mao, Luyang Liu, Hongmin Liu, Zhanyong Wei, Haiwei Xu
Summary: Compound 3D, a butene lactone derivative, showed promising antiviral activity against H1N1 influenza virus in vitro with low toxicity, inhibiting viral replication, mRNA and protein expression dose-dependently.
Article
Immunology
Krystyna Naumenko, Svitlana Zahorodnia, Calin Pop, Nodari Rizun
Summary: Viral infections, especially those caused by influenza viruses, are significant in modern medicine due to their rapid transmission and mutation, resulting in socioeconomic consequences. Silver nanoparticles (AgNPs) have been identified as effective antimicrobial agents. This study demonstrates their strong antiviral properties against influenza A virus infection, without cytotoxicity at inhibitory concentrations, making them a potential post-infection virostatic agent.
JOURNAL OF VIRUS ERADICATION
(2023)
Article
Pharmacology & Pharmacy
Eun-Bin Kwon, You-Chang Oh, Youn-Hwan Hwang, Wei Li, Seok-Man Park, Ryong Kong, Young Soo Kim, Jang-Gi Choi
Summary: OCD20015-V009 modulates murine innate immune response by regulating macrophages to inhibit influenza A virus replication, reducing mortality in infected mice. Chlorogenic acid and ginsenoside Rd are identified as antiviral components in this herbal mix, enhancing mice's resistance to viral infections. Further studies are needed to clarify the protective effects of active components in OCD20015-V009 against influenza A viruses.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Microbiology
Fanhua Wei, Chengjiang Gao, Yujiong Wang
Summary: Influenza virus infection can lead to cytokine storms, contributing to severe outcomes. Immunomodulatory drugs offer a promising approach for treating hypercytokinemia induced by acute viral infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)