The mechanisms of renin–angiotensin system in hepatocellular carcinoma: From the perspective of liver fibrosis, HCC cell proliferation, metastasis and angiogenesis, and corresponding protection measures
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The mechanisms of renin–angiotensin system in hepatocellular carcinoma: From the perspective of liver fibrosis, HCC cell proliferation, metastasis and angiogenesis, and corresponding protection measures
Authors
Keywords
Hepatocellular carcinoma, Renin–Angiotensin System, Liver Fibrosis, Cell Proliferation, Angiogenesis
Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 141, Issue -, Pages 111868
Publisher
Elsevier BV
Online
2021-07-14
DOI
10.1016/j.biopha.2021.111868
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Angiotensin II Receptor Blocker Losartan Sensitizes Human Liver Cancer Cells to Lenvatinib-Mediated Cytostatic and Angiostatic Effects
- (2021) Hirotetsu Takagi et al. Cells
- Irbesartan inhibits metastasis by interrupting the adherence of tumor cell to endothelial cell induced by angiotensin II in hepatocellular carcinoma
- (2021) Long-Hai Feng et al. Annals of Translational Medicine
- Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS
- (2020) Yun Huang et al. CLINICAL SCIENCE
- Renin-angiotensin system inhibitors and development of hepatocellular carcinoma: A systematic review and meta-analysis
- (2020) Fereshteh Asgharzadeh et al. CURRENT PHARMACEUTICAL DESIGN
- Angiotensin‐(1‐7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism
- (2020) Li‐Ni Song et al. FASEB JOURNAL
- Potential biomarkers Ang II/AT1R and S1P/S1PR1 predict the prognosis of hepatocellular carcinoma
- (2020) Yuanyuan Ji et al. Oncology Letters
- Prognostic and Immunological Value of Angiotensin-Converting Enzyme 2 in Pan-Cancer
- (2020) Huan Feng et al. Frontiers in Molecular Biosciences
- AT1R-Specific Ligand Angiotensin II as a Novel SPECT Agent for Hepatocellular Carcinoma Diagnosis
- (2020) Yuanbiao Tu et al. ACS Sensors
- Angiotensin-converting enzyme inhibitors have adverse effects in anti-angiogenesis therapy for hepatocellular carcinoma
- (2020) Su Zhang et al. CANCER LETTERS
- Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways
- (2019) Valeria Burghi et al. Frontiers in Pharmacology
- The renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via the JAK2/STAT pathway
- (2019) Lei He et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways
- (2019) Jing Wang et al. TOXICOLOGY IN VITRO
- Systematic review: Renin-angiotensin system inhibitors in chemoprevention of hepatocellular carcinoma
- (2019) Michele Barone et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells
- (2019) Le Wang et al. EBioMedicine
- Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen
- (2019) Estrellita Uijl et al. HYPERTENSION
- Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
- (2019) Ning Liu et al. MEDIATORS OF INFLAMMATION
- Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats
- (2019) Vivian Paulino Figueiredo et al. Oxidative Medicine and Cellular Longevity
- Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinoma
- (2019) Tan Boon Toh et al. JOURNAL OF HEPATOLOGY
- Clathrin switches Transforming Growth Factor-β role to pro-tumorigenic in liver cancer
- (2019) Daniel Caballero-Díaz et al. JOURNAL OF HEPATOLOGY
- A global view of hepatocellular carcinoma: trends, risk, prevention and management
- (2019) Ju Dong Yang et al. Nature Reviews Gastroenterology & Hepatology
- Long Non-coding RNA MALAT1 Promotes Angiogenesis and Immunosuppressive Properties of HCC Cells by sponging miR-140
- (2019) Zhou-Hua Hou et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse
- (2019) Chinmayee Sethy et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Pathways of hepatic and renal damage through non‐classical activation of the renin‐angiotensin system in chronic liver disease
- (2019) Giovanni Sansoè et al. LIVER INTERNATIONAL
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
- (2019) Jiajie Hou et al. Molecular Cancer
- Anti-Cancer Effects of 3, 3’-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK
- (2019) Yuanyue Jiang et al. Frontiers in Pharmacology
- Renin-angiotensin inhibitors were associated with improving outcomes of hepatocellular carcinoma with primary hypertension after hepatectomy
- (2019) Long-Hai Feng et al. Annals of Translational Medicine
- Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2
- (2018) Elham Ahmadian et al. BIOMEDICINE & PHARMACOTHERAPY
- Dynamic Hyaluronan drives liver endothelial cells towards angiogenesis
- (2018) Sampa Ghose et al. BMC CANCER
- FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice
- (2018) Xuebo Pan et al. Cell Metabolism
- Angiopoietin-2 (Ang-2) is a useful serum tumor marker for liver cancer in the Chinese population
- (2018) Yuxin Chen et al. CLINICA CHIMICA ACTA
- Angiotensin II and tumor necrosis factor-α stimulate the growth, migration and invasion of BEL-7402 cells via down-regulation of GRK2 expression
- (2018) Zhou-wei Xu et al. DIGESTIVE AND LIVER DISEASE
- NADPH oxidase 5 promotes proliferation and fibrosis in human hepatic stellate cells
- (2018) Aitor Andueza et al. FREE RADICAL BIOLOGY AND MEDICINE
- Altered global microRNA expression in hepatic stellate cells LX-2 by angiotensin-(1–7) and miRNA-1914-5p identification as regulator of pro-fibrogenic elements and lipid metabolism
- (2018) Brenda de Oliveira da Silva et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo
- (2018) Yingying Mao et al. International Journal of Biological Sciences
- TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
- (2018) Laia Caja et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Redox signal-mediated TRPM2 promotes Ang II-induced adipocyte insulin resistance via Ca 2+ -dependent CaMKII/JNK cascade
- (2018) Min Gao et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B
- (2018) Sameh Saber et al. TOXICOLOGY LETTERS
- MicroRNA-34a Promotes MICB Expression in Hepatocytes
- (2018) Meng-Tao Zhou et al. CARCINOGENESIS
- Renin-angiotensin-aldosterone system in cirrhosis: There’s room to try!
- (2018) Marco Di Pascoli et al. DIGESTIVE AND LIVER DISEASE
- ACE I allele is associated with more severe portal hypertension in patients with liver cirrhosis: A pilot study
- (2018) Brigida E. Annicchiarico et al. DIGESTIVE AND LIVER DISEASE
- Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in murine non-alcoholic fatty liver disease
- (2018) Sander Lefere et al. HEPATOLOGY
- Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells
- (2018) Jingya Lyu et al. JOURNAL OF LIPID RESEARCH
- Angiotensin 1–7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer
- (2018) Kamila Domińska et al. Scientific Reports
- Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin angiotensin system
- (2018) Eva Gatineau et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats
- (2018) Norihisa Nishimura et al. BMC CANCER
- CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer
- (2018) Mohammed Benkheil et al. EXPERIMENTAL CELL RESEARCH
- Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes
- (2018) Gholamreza Bidkhori et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway
- (2018) Shikun Yang et al. Cell Death & Disease
- MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway
- (2018) Jie Bao et al. Cell Death & Disease
- Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
- (2018) Quentin Bayard et al. Nature Communications
- Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
- (2017) Heleia Roca-Ho et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest
- (2017) Kyoko Oura et al. ONCOLOGY REPORTS
- Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy
- (2017) Matthias Pinter et al. Science Translational Medicine
- In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis
- (2017) Wei Yang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis
- (2017) Aline Silva Miranda et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Renin angiotensin system in liver diseases: Friend or foe?
- (2017) Ana Cristina Simões e Silva et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism
- (2017) Ao Li et al. Scientific Reports
- Angiotensin-(1–7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation
- (2016) Shuang-Ming Cai et al. ANTIOXIDANTS & REDOX SIGNALING
- Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway
- (2016) Fangtian Fan et al. BIOMEDICINE & PHARMACOTHERAPY
- NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling
- (2016) Lixing Zhang et al. CANCER RESEARCH
- Angiotensin(1–7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H 2 O 2 -activated NLRP3 inflammasome/IL-1β/Smad circuit
- (2016) Li-Li Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Structure and functions of angiotensinogen
- (2016) Hong Lu et al. HYPERTENSION RESEARCH
- Involvement of miR-30c in hepatic stellate cell activation through the repression of plasminogen activator inhibitor-1
- (2016) Maoyao Wen et al. LIFE SCIENCES
- Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma
- (2016) Ji-Zong Lin et al. Molecular Medicine Reports
- TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation
- (2016) Bin Xiao et al. MOLECULES
- Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells
- (2016) YIYAN LEI et al. ONCOLOGY REPORTS
- Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells
- (2016) Taeho Kwon et al. STEM CELLS
- The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats
- (2015) Saliha Sena Karcioglu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients
- (2015) Antonio Facciorusso et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Unknown
- (2015) Yanping Liu et al. MOLECULAR MEDICINE
- ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice
- (2015) Kai Y Mak et al. MOLECULAR THERAPY
- Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells
- (2014) Ming-Ju Hsieh et al. BRITISH JOURNAL OF PHARMACOLOGY
- Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction
- (2014) Tosan Ehanire et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
- (2012) Hashem B. El-Serag GASTROENTEROLOGY
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Insulin Resistance and Other Metabolic Risk Factors in the Pathogenesis of Hepatocellular Carcinoma
- (2011) Asma Siddique et al. Clinics in Liver Disease
- Impact of Renin-Angiotensin System in Hepatocellular Carcinoma
- (2011) H. Yoshiji et al. CURRENT CANCER DRUG TARGETS
- Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
- (2009) Jing-song Chen et al. HEPATOLOGY RESEARCH
- Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy
- (2008) B. B. Friday et al. CLINICAL CANCER RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search