Preclinical Studies Identify Non-Apoptotic Low-Level Caspase-3 as Therapeutic Target in Pemphigus Vulgaris

Involvement of the Apoptotic Mechanism in Pemphigus Foliaceus Autoimmune Injury of the Skin

(2014) N. Li et al.   JOURNAL OF IMMUNOLOGY

Pemphigus Vulgaris IgG Directly Inhibit Desmoglein 3-Mediated Transinteraction

(2014) W.-M. Heupel et al.   JOURNAL OF IMMUNOLOGY

No Evidence of Apoptotic Cells in Pemphigus Acantholysis

(2014) Ineke C. Janse et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nanorobotic Investigation Identifies Novel Visual, Structural and Functional Correlates of Autoimmune Pathology in a Blistering Skin Disease Model

(2014) Kristina Seiffert-Sinha et al.   PLoS One

EGFR inhibitors erlotinib and lapatinib ameliorate epidermal blistering in pemphigus vulgaris in a non-linear, V-shaped relationship

(2013) Beyza S. Sayar et al.   EXPERIMENTAL DERMATOLOGY

MAPKAP Kinase 2 (MK2)-Dependent and -Independent Models of Blister Formation in Pemphigus Vulgaris

(2013) Xuming Mao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-3 and RasGAP: a stress-sensing survival/demise switch

(2013) Hadi Khalil et al.   TRENDS IN CELL BIOLOGY

Apoptotic Pathways in the Pathogenesis of Pemphigus: Targets for New Therapies

(2012) Roberta Lotti et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Pemphigus autoimmunity: Hypotheses and realities

(2011) Sergei A. Grando   AUTOIMMUNITY

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

TRAIL-Induced Keratinocyte Differentiation Requires Caspase Activation and p63 Expression

(2011) Nan-Lin Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An Adult Passive Transfer Mouse Model to Study Desmoglein 3 Signaling in Pemphigus Vulgaris

(2011) Katja Schulze et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alopecia as a rare but distinct manifestation of pemphigus vulgaris

(2011) O. Veraitch et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and Can Be Reversed by Expression of Exogenous Dsg3

(2010) Jean M. Jennings et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-3 Is Transiently Activated without Cell Death during Early Antigen Driven Expansion of CD8+ T Cells In Vivo

(2010) Scott McComb et al.   PLoS One

Apoptosis in pemphigus

(2009) Enno Schmidt et al.   AUTOIMMUNITY REVIEWS

An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris

(2009) Maider Pretel et al.   EXPERIMENTAL DERMATOLOGY

Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis

(2009) Sergei A. Grando et al.   EXPERIMENTAL DERMATOLOGY

Biphasic Activation of p38MAPK Suggests That Apoptosis Is a Downstream Event in Pemphigus Acantholysis

(2009) Hua En Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL

(2009) Sun Mi Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Apoptosis is not required for acantholysis in pemphigus vulgaris

(2008) Enno Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals

(2008) Vernonica E. Franklin-Tong et al.   BIOCHEMICAL JOURNAL

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris

(2008) Nicola Cirillo et al.   EXPERIMENTAL DERMATOLOGY

Targeted Cleavage of Signaling Proteins by Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells

(2008) Irene Puga et al.   IMMUNITY

Outside-in Signaling through Integrins and Cadherins: A Central Mechanism to Control Epidermal Growth and Differentiation?

(2008) Eliane J. Müller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

EGFR and ADAMs Cooperate to Regulate Shedding and Endocytic Trafficking of the Desmosomal Cadherin Desmoglein 2

(2008) Jodi L. Klessner et al.   MOLECULAR BIOLOGY OF THE CELL

Desmosome structure, composition and function

(2007) David Garrod et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Induction of p38MAPK and HSP27 Phosphorylation in Pemphigus Patient Skin

(2007) Paula Berkowitz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY