Oncogenic cancer/testis antigens are a hallmarker of cancer and a sensible target for cancer immunotherapy

The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer

(2020) Yichi Xu et al.   CELL PROLIFERATION

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

(2020) Zhihao Lu et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy

(2020) Afsheen Raza et al.   Journal of Translational Medicine

Identification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse

(2020) Nataly Mancette Rijensky et al.   MOLECULAR & CELLULAR PROTEOMICS

Exploratory open-label clinical study to determine the S-588410 cancer peptide vaccine-induced tumor-infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients

(2020) H. Daiko et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma

(2020) Yunyan Wu et al.   CARCINOGENESIS

Diffuse PRAME expression is highly specific for malignant melanoma in the distinction from clear cell sarcoma

(2020) Shyam S. Raghavan et al.   JOURNAL OF CUTANEOUS PATHOLOGY

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Expression of cancer–testis antigens in esophageal cancer and their progress in immunotherapy

(2019) Yujie Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets

(2019) Kaipeng Xie et al.   Journal of Ovarian Research

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer

(2019) Ghaneya Al-Khadairi et al.   Journal of Translational Medicine

Hypomethylation‐mediated activation of cancer/testis antigen KK‐LC‐1 facilitates hepatocellular carcinoma progression through activating the Notch1/Hes1 signalling

(2019) Zhiqiang Chen et al.   CELL PROLIFERATION

Cancer-Testis Antigen Peptide Vaccine for Cancer Immunotherapy: Progress and Prospects

(2019) Xiao Wei et al.   Translational Oncology

First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1

(2019) Neeta Somaiah et al.   CLINICAL CANCER RESEARCH

Cancer Testis Antigens and Immunotherapy: Where Do We Stand in the Targeting of PRAME?

(2019) Ghaneya Al-Khadairi et al.   Cancers

Analyses of molecular and histopathologic features and expression of PRAME by immunohistochemistry in mucosal melanomas

(2019) Aimi Toyama et al.   MODERN PATHOLOGY

Evaluation of cancer testis antigen (CT10, PRAME) and MHC I expression in high-grade urothelial carcinoma of the bladder

(2019) Anjelica Hodgson et al.   VIRCHOWS ARCHIV

Immunohistochemistry for PRAME in the Distinction of Nodal Nevi From Metastatic Melanoma

(2019) Cecilia Lezcano et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

PRAME as a Potential Biomarker for Liver Metastasis of Gastric Cancer

(2019) Hayato Baba et al.   ANNALS OF SURGICAL ONCOLOGY

Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer

(2019) Zhaolei Cui et al.   CLINICA CHIMICA ACTA

MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells

(2019) Yuan Mao et al.   Journal of Hematology & Oncology

NY-ESO-1 expression in solid tumors predicts prognosis

(2019) Huiyu Wang et al.   MEDICINE

Emerging role of sperm-associated antigen 9 in tumorigenesis

(2018) Jun Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1

(2018) Hiroki Kusumoto et al.   CANCER SCIENCE

Cancer testis antigens as immunogenic and oncogenic targets in breast cancer

(2018) Abeer M Mahmoud   Immunotherapy

MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial

(2018) Brigitte Dreno et al.   LANCET ONCOLOGY

Evolution of oncogenic signatures of mutation hotspots in tyrosine kinases supports the atavistic hypothesis of cancer

(2018) Weiran Chen et al.   Scientific Reports

NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives

(2018) Remy Thomas et al.   Frontiers in Immunology

Gene Expression Profiling and PRAME Status Versus Tumor-Node-Metastasis Staging for Prognostication in Uveal Melanoma

(2018) Louis Cai et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Expression of NY-ESO-1, MAGE-A3, PRAME and WT1 in different subgroups of breast cancer: An indication to immunotherapy?

(2018) Anna Tessari et al.   BREAST

Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer

(2018) Fabian Coscia et al.   CELL

TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231

(2018) Ling-yu Ding et al.   PLoS One

Detection of KK-LC-1 Protein, a Cancer/Testis Antigen, in Patients with Breast Cancer

(2018) YASUSHI KONDO et al.   ANTICANCER RESEARCH

A phase II trial of recombinant MAGE-A3 protein with immunostimulant AS15 in combination with high-dose Interleukin-2 (HDIL2) induction therapy in metastatic melanoma

(2018) Jennifer L. McQuade et al.   BMC CANCER

Targeting CTCFL/BORIS for the immunotherapy of cancer

(2018) Dmitri Loukinov   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination With or Without Ipilimumab

(2018) Theodore S Nowicki et al.   CLINICAL CANCER RESEARCH

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

(2018) Francis Mussai et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

(2017) Zachary D. Smith et al.   NATURE

Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

(2017) Vandeclecio Lira da Silva et al.   Oncotarget

Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy

(2017) Ryota Horibe et al.   PLoS One

MAGE-A1 promotes melanoma proliferation and migration through C-JUN activation

(2016) Dong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MAGE-A family expression is correlated with poor survival of patients with lung adenocarcinoma: a retrospective clinical study based on tissue microarray

(2016) Meixiang Sang et al.   JOURNAL OF CLINICAL PATHOLOGY

Landscape of tumor-infiltrating T cell repertoire of human cancers

(2016) Bo Li et al.   NATURE GENETICS

Oncogenic role of epithelial cell transforming sequence 2 in lung adenocarcinoma cells

(2016) Hongyi Tan et al.   Experimental and Therapeutic Medicine

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

(2016) Michal Bassani-Sternberg et al.   Nature Communications

Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer

(2016) Chen Xie et al.   CELLULAR ONCOLOGY

SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade

(2016) Wei Xue et al.   OncoImmunology

Cancer/Testis Antigens Trigger Epithelial-Mesenchymal Transition and Genesis of Cancer Stem-Like Cells

(2015) Ping Yang et al.   CURRENT PHARMACEUTICAL DESIGN

DNA hypomethylation-mediated activation ofCancer/Testis Antigen 45(CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer

(2015) Wa Zhang et al.   Epigenetics

Targeting Tumor Initiating Cells through Inhibition of Cancer Testis Antigens and Notch Signaling: A Hypothesis

(2015) Michela Colombo et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Expression of NY-ESO-1 in Triple-Negative Breast Cancer Is Associated with Tumor-Infiltrating Lymphocytes and a Good Prognosis

(2015) Hee Jin Lee et al.   ONCOLOGY

Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer

(2015) Kimberly E. Maxfield et al.   Nature Communications

Oncogenic cancer/testis antigens: prime candidates for immunotherapy

(2015) Morten F. Gjerstorff et al.   Oncotarget

Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: Current status and challenges

(2015) Anil Suri et al.   World Journal of Gastrointestinal Oncology

MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4

(2015) Lynnette Marcar et al.   PLoS One

High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cells

(2014) Jianguo Wen et al.   BRITISH JOURNAL OF HAEMATOLOGY

CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis

(2014) B Shang et al.   Cell Death & Disease

Cause and Consequence of Cancer/Testis Antigen Activation in Cancer

(2013) Angelique W. Whitehurst   Annual Review of Pharmacology and Toxicology

Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration

(2013) Anja Koop et al.   Cell Communication and Signaling

The expression of stem cell protein Piwil2 and piR-932 in breast cancer

(2013) Hao Zhang et al.   SURGICAL ONCOLOGY-OXFORD

Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene

(2013) R. Yamada et al.   TISSUE ANTIGENS

HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression

(2012) Pierre-François Cartron et al.   Molecular Oncology

T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γcnull mice

(2011) Yoshitaka Shirakura et al.   CANCER SCIENCE

MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis

(2011) Serena Germano et al.   INTERNATIONAL JOURNAL OF CANCER

A ballsy search for cancer targets

(2011) Megan Scudellari   NATURE MEDICINE

Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer Drugs

(2010) Youngmi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas

(2010) Y.-T. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequency and prognostic relevance of cancer testis antigen 45 expression in multiple myeloma

(2009) Valéria C.C. Andrade et al.   EXPERIMENTAL HEMATOLOGY

Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer

(2009) Yao-Tseng Chen et al.   INTERNATIONAL JOURNAL OF CANCER