Article
Anatomy & Morphology
Xiangjun Lu, Jian Shen, Siyuan Huang, Haitao Wang, Dongdong Liu
Summary: This study demonstrates that the low expression of CLEC3B in LUAD cells leads to decreased cell adhesion capability, enhanced EMT, migration, and invasion, which is associated with the p53 signaling pathway.
Article
Oncology
Shuai Huang, Xudong Zhang, Kai Luo, Li Jiang, Jianhua Jiang, Renfeng Li
Summary: In this study, OSBP2 was found to be highly expressed in PDAC and its upregulation promoted the progression of PDAC, including increased cell migration, invasion, proliferation, chemotherapy resistance, and decreased apoptosis. Furthermore, overexpression of OSBP2 resulted in downregulation of the cell adhesion molecule E-cadherin and upregulation of other transcription factors. Therefore, OSBP2 may serve as a potential diagnostic and therapeutic target for PDAC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Minglian Qiu, Meizhen Chen, Zhongping Lan, Bo Liu, Jinbao Xie, Xu Li
Summary: This study reveals the role and regulatory mechanism of PVT1/EIF4A3/circLMNB2 in lung adenocarcinoma (LUAD) and confirms their ability to increase the malignant behaviors of LUAD cells, providing a new perspective for the clinical treatment of LUAD.
Article
Oncology
Eun Ju Kim, Jeong Seon Kim, Sieun Lee, Inyoung Cheon, Seo Ree Kim, Yoon Ho Ko, Keunsoo Kang, Xiaochao Tan, Jonathan M. Kurie, Young-Ho Ahn
Summary: The study found that lnc-Nr2f1 is upregulated by ZEB1 and NR2F1 in lung adenocarcinoma cells, and promotes migration and invasion of these cells by regulating TWIST2.
Article
Oncology
Wen-Yueh Hung, Wei-Jiunn Lee, Guo-Zhou Cheng, Ching-Han Tsai, Yi-Chieh Yang, Tsung-Ching Lai, Ji-Qing Chen, Chi-Li Chung, Jer-Hwa Chang, Ming-Hsien Chien
Summary: Our study showed that penfluridol can reduce the migration, invasion, and adhesion of LADC cells, potentially by inhibiting MMP-12 expression and reversing MMP-12-induced EMT. MMP-12 may serve as a useful biomarker for predicting LADC progression and as a promising penfluridol target for treating metastatic LADC.
Article
Oncology
Chunli Wu, Bo Dong, Lan Huang, Yafei Liu, Guanchao Ye, Shihao Li, Yu Qi
Summary: This study revealed that SPTBN2 was significantly upregulated in LUAD tissues compared to normal tissues. High expression of SPTBN2 in LUAD was associated with poor prognosis and could promote the proliferation, migration, and invasion of LUAD cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jun Huang, Qiuhua Yu, Yanjuan Zhou, Ying Chu, Feng Jiang, Qiang Wang
Summary: Our study demonstrated that FAM201A was significantly upregulated in LUAD tissues and cells, and its knockdown suppressed cell proliferation, migration, and invasion while promoting apoptosis. FAM201A was shown to affect LUAD progression by targeting miR-7515 to promote GLO1 expression. Additionally, FAM201A downregulation also suppressed LUAD development in vivo, indicating its potential as a novel therapeutic target for LUAD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huihui Wang, Hao Zhang, Zhirong Sun, Wankun Chen, Changhong Miao
Summary: The research showed that GABABR1 inhibits the migration and invasion of CRC cells by suppressing EMT and the Hippo/YAP1 pathway, indicating that GABABR1 could be a potential therapeutic target for CRC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Yan-Yi Li, Wen Li, Guang-Zhe Chang, Yan-Mei Li
Summary: KTN1-AS1 was found to be highly expressed in lung adenocarcinoma and associated with poor prognosis in patients; DEPDC1 was identified as a downstream protein associated with KTN1-AS1; The KTN1-AS1/DEPDC1 axis was implicated in lung adenocarcinoma tumorigenesis by activating the epithelial-mesenchymal transition process.
Article
Genetics & Heredity
Xiaomei Tang, Xiaoyan Hua, Xujin Peng, Yongyan Pei, Zhigang Chen
Summary: This study identified the important role of the long noncoding RNA (lncRNA) PCAT19 in lung adenocarcinoma (LUAD). PCAT19 was found to regulate the proliferation, migration, and invasion of LUAD cells and may serve as a potential biomarker for the diagnosis of LUAD.
FRONTIERS IN GENETICS
(2022)
Review
Biotechnology & Applied Microbiology
Yanhong Tu, Fan Mei
Summary: This study found that miR-3648 is overexpressed in LUAD cells and tissues and enhances the proliferation, migration, and invasion abilities of LUAD by targeting SOCS2. This finding may provide a novel therapeutic strategy for patients with LUAD.
Article
Pharmacology & Pharmacy
Nongyao Nonpanya, Kittipong Sanookpan, Nicharat Sriratanasak, Chanida Vinayanuwattikun, Duangdao Wichadakul, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Artocarpin targets FAK to suppress EMT and migratory behaviors of lung cancer cells, without affecting normal lung cells.
Article
Pathology
Chunxiu Hu, Jianxiang Wu, Li Wang, Xuewu Liu, Bin Da, Yi Liu, Lingyan Huang, Qin Chen, Yuefang Tong, Zhongyu Jiang
Summary: The study revealed that CDCA8 was overexpressed in LUAD tissues while its upstream miRNA miR-133b was downregulated, and miR-133b could inhibit the proliferation, invasion, and migration of LUAD cells by targeting CDCA8.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medicine, Research & Experimental
Lian Yu, Rong Qiao, Jianlin Xu, Baohui Han, Runbo Zhong
Summary: This study aimed to characterize the functions of pseudogene-derived long non-coding RNA (lncRNA) FAM207BP in lung adenocarcinoma (LUAD). High expression of FAM207BP in LUAD was associated with worse overall survival (OS) and disease-free survival (DFS) time, and was significantly related to gender. Knockdown of FAM207BP suppressed cellular viability, migration, and invasion in LUAD cells, and its expression was negatively related to B cell infiltration levels. Gene Set Enrichment Analysis (GSEA) showed that high FAM207BP expression was involved in gene expression regulation, while low expression was related to immune response.
Article
Oncology
Gang Yang, Guan Wang, Yongfu Xiong, Ji Sun, Weinan Li, Tao Tang, Jingdong Li
Summary: The study demonstrated that CDC20 is highly expressed in HCC and its high expression is associated with poor prognosis. Silencing of CDC20 inhibited the proliferation, migration, and invasion of HCC cells, while increasing the expression of E-cadherin.
MOLECULAR MEDICINE REPORTS
(2021)