The molecular mechanisms of listeriolysin O-induced lipid membrane damage

Phosphocholine antagonizes listeriolysin O-induced host cell responses of Listeria monocytogenes

(2020) Luigi La Pietra et al.   JOURNAL OF INFECTIOUS DISEASES

Design of Protein Logic Gate System Operating on Lipid Membranes

(2020) Neža Omersa et al.   ACS Synthetic Biology

An Inducible Cre-lox System to Analyze the Role of LLO in Listeria monocytogenes Pathogenesis

(2020) Brittney N. Nguyen et al.   Toxins

All major cholesterol-dependent cytolysins use glycans as cellular receptors

(2020) Lucy K. Shewell et al.   Science Advances

Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells

(2020) Caroline Peron-Cane et al.   PLoS Pathogens

Live Imaging Reveals Listeria Hijacking of E-Cadherin Recycling as It Crosses the Intestinal Barrier

(2020) Minhee Kim et al.   CURRENT BIOLOGY

Listeriosis in mainland China: a systematic review

(2019) Fan Zhangling et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

(2019) Kristin R. Wade et al.   mBio

Correlated protein conformational states and membrane dynamics during attack by pore-forming toxins

(2019) Ilanila I. Ponmalar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane perforation by the pore-forming toxin pneumolysin

(2019) Martin Vögele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific targeting of a pore-forming toxin (listeriolysin O) to LHRH-positive cancer cells using LHRH targeting peptide

(2019) Mohammad Hassan Kheirandish et al.   TOXICON

pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles

(2019) Ismael Plaza-GA et al.   JOURNAL OF NANOBIOTECHNOLOGY

The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection

(2018) Chen Chen et al.   Cell Host & Microbe

Listeriolysin O binding affects cholesterol and phospholipid acyl chain dynamics in fluid cholesterol-rich bilayers

(2018) Mirijam Kozorog et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cholesterol Enriched Archaeosomes as a Molecular System for Studying Interactions of Cholesterol-Dependent Cytolysins with Membranes

(2018) Saša Rezelj et al.   JOURNAL OF MEMBRANE BIOLOGY

Host cell perforation by listeriolysin O (LLO) activates a Ca2+-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes Listeria monocytogenes internalization independently of membrane resealing

(2018) Jonathan G. T. Lam et al.   MOLECULAR BIOLOGY OF THE CELL

LLO-mediated Cell Resealing System for Analyzing Intracellular Activity of Membrane-impermeable Biopharmaceuticals of Mid-sized Molecular Weight

(2018) Masataka Murakami et al.   Scientific Reports

19F NMR studies provide insights into lipid membrane interactions of listeriolysin O, a pore forming toxin from Listeria monocytogenes

(2018) Mirijam Kozorog et al.   Scientific Reports

To Be Cytosolic or Vacuolar: The Double Life of Listeria monocytogenes

(2018) Hélène Bierne et al.   Frontiers in Cellular and Infection Microbiology

Missing elimination via membrane vesicle shedding contributes to the diminished calcium sensitivity of listeriolysin O

(2018) Jana Maurer et al.   Scientific Reports

Plasma membrane damage caused by Listeriolysin O is not repaired through endocytosis of the membrane pore

(2018) Lars Nygård Skalman et al.   Biology Open

Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement

(2018) Margaret N. Holme et al.   ACS Central Science

Listeriolysin O: A phagosome-specific cytolysin revisited

(2018) Brittney N. Nguyen et al.   CELLULAR MICROBIOLOGY

Listeria monocytogenes virulence factors, including Listeriolysin O, are secreted in biologically active Extracellular Vesicles

(2018) Carolina Coelho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study

(2017) Caroline Charlier et al.   LANCET INFECTIOUS DISEASES

Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis

(2017) Lilliana Radoshevich et al.   NATURE REVIEWS MICROBIOLOGY

Listeria monocytogenestriggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy

(2017) Gabriel Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

(2017) Katharina van Pee et al.   eLife

Engineering a pH responsive pore forming protein

(2017) Matic Kisovec et al.   Scientific Reports

Protein–lipid interactions and non-lamellar lipidic structures in membrane pore formation and membrane fusion

(2016) Robert J.C. Gilbert   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recombinant broad-range phospholipase C from Listeria monocytogenes exhibits optimal activity at acidic pH

(2016) Qiongying Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Efferocytosis of apoptotic human papillomavirus-positive cervical cancer cells by human primary fibroblasts

(2016) François Hermetet et al.   BIOLOGY OF THE CELL

Atomic force microscopy of membrane pore formation by cholesterol dependent cytolysins

(2016) Adrian W Hodel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Super-resolution Stimulated Emission Depletion-Fluorescence Correlation Spectroscopy Reveals Nanoscale Membrane Reorganization Induced by Pore-Forming Proteins

(2016) Nirod Kumar Sarangi et al.   LANGMUIR

Nanoscale dynamics of phospholipids reveals an optimal assembly mechanism of pore-forming proteins in bilayer membranes

(2016) Nirod Kumar Sarangi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA inListeria

(2016) Michael Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

(2016) Sara L. Lawrence et al.   STRUCTURE

Listeriolysin O Membrane Damaging Activity Involves Arc Formation and Lineaction -- Implication for Listeria monocytogenes Escape from Phagocytic Vacuole

(2016) Yi Ruan et al.   PLoS Pathogens

How Lipid Membranes Affect Pore Forming Toxin Activity

(2015) Nejc Rojko et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria

(2015) Rodney K. Tweten et al.   Annual Review of Microbiology

Assembly of streptolysin O pores assessed by quartz crystal microbalance and atomic force microscopy provides evidence for the formation of anchored but incomplete oligomers

(2015) Sarah E. Stewart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PrfA regulation offsets the cost ofListeriavirulence outside the host

(2015) Radhakrishnan B. Vasanthakrishnan et al.   ENVIRONMENTAL MICROBIOLOGY

Directly Observing the Lipid-Dependent Self-Assembly and Pore-Forming Mechanism of the Cytolytic Toxin Listeriolysin O

(2015) Estefania Mulvihill et al.   NANO LETTERS

Glutathione activates virulence gene expression of an intracellular pathogen

(2015) Michelle L. Reniere et al.   NATURE

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

(2015) Lisa Brown et al.   NATURE REVIEWS MICROBIOLOGY

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review

(2015) Kuldeep Dhama et al.   VETERINARY QUARTERLY

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

(2015) Sara L. Lawrence et al.   Scientific Reports

Plasticity of Listeriolysin O Pores and its Regulation by pH and Unique Histidine

(2015) Marjetka Podobnik et al.   Scientific Reports

Biological Effects of Listeriolysin O: Implications for Vaccination

(2015) K. G. Hernández-Flores et al.   Biomed Research International

Listeriolysin O Affects the Permeability of Caco-2 Monolayer in a Pore-Dependent and Ca2+-Independent Manner

(2015) Miša Mojca Cajnko et al.   PLoS One

Reservoirs of Listeria Species in Three Environmental Ecosystems

(2014) Kristina Linke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin, Listeriolysin O, after Evasion from Phagosome into the Cytoplasm

(2014) H. Hara et al.   JOURNAL OF IMMUNOLOGY

The Diaphanous-Related Formins Promote Protrusion Formation and Cell-to-Cell Spread ofListeria monocytogenes

(2014) Ramzi Fattouh et al.   JOURNAL OF INFECTIOUS DISEASES

The global burden of listeriosis: a systematic review and meta-analysis

(2014) Charline Maertens de Noordhout et al.   LANCET INFECTIOUS DISEASES

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread

(2014) Mark A. Czuczman et al.   NATURE

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

(2014) Lucy K. Shewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane pore formation at protein–lipid interfaces

(2014) Robert J.C. Gilbert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation

(2014) Stefan Köster et al.   Nature Communications

Incomplete pneumolysin oligomers form membrane pores

(2014) A. F.- P. Sonnen et al.   Open Biology

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

(2014) Carl Leung et al.   eLife

Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity

(2014) Stanley Gititu Kimani et al.   Frontiers in Immunology

What planar lipid membranes tell us about the pore-forming activity of cholesterol-dependent cytolysins

(2013) Marta Marchioretto et al.   BIOPHYSICAL CHEMISTRY

Listeriaphospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures

(2013) Ivan Tattoli et al.   EMBO JOURNAL

Anthropogenic impact on the presence of L. monocytogenes in soil, fruits, and vegetables

(2013) Barbara Szymczak et al.   FOLIA MICROBIOLOGICA

Fluxes of Ca2+and K+Are Required for the Listeriolysin O-Dependent Internalization Pathway of Listeria monocytogenes

(2013) Stephen Vadia et al.   INFECTION AND IMMUNITY

The Pore-Forming Toxin Listeriolysin O Is Degraded by Neutrophil Metalloproteinase-8 and Fails To Mediate Listeria monocytogenes Intracellular Survival in Neutrophils

(2013) E. Arnett et al.   JOURNAL OF IMMUNOLOGY

Structural Studies of Streptococcus pyogenes Streptolysin O Provide Insights into the Early Steps of Membrane Penetration

(2013) Susanne C. Feil et al.   JOURNAL OF MOLECULAR BIOLOGY

Listeriolysin O as a strong immunogenic molecule for the development of new anti-tumor vaccines

(2013) Rui Sun et al.   Human Vaccines & Immunotherapeutics

Effects of MACPF/CDC proteins on lipid membranes

(2012) Robert J. C. Gilbert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification and Characterization of the First Cholesterol-Dependent Cytolysins from Gram-Negative Bacteria

(2012) Eileen M. Hotze et al.   INFECTION AND IMMUNITY

Listeriolysin O: the Swiss army knife of Listeria

(2012) Mélanie Anne Hamon et al.   TRENDS IN MICROBIOLOGY

Functional Characterization of Crp/Fnr-Type Global Transcriptional Regulators in Desulfovibrio vulgaris Hildenborough

(2011) Aifen Zhou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

pH dependence of listeriolysin O aggregation and pore-forming ability

(2011) Andrej Bavdek et al.   FEBS Journal

K+Efflux Is Required for Histone H3 Dephosphorylation by Listeria monocytogenes Listeriolysin O and Other Pore-Forming Toxins

(2011) Mélanie Anne Hamon et al.   INFECTION AND IMMUNITY

The Metalloprotease of Listeria monocytogenes Is Regulated by pH

(2011) B. M. Forster et al.   JOURNAL OF BACTERIOLOGY

Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome

(2011) A. L. Radtke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The arsenal of virulence factors deployed byListeria monocytogenesto promote its cell infection cycle

(2011) Ana Camejo et al.   Virulence

The Pore-Forming Toxin Listeriolysin O Mediates a Novel Entry Pathway of L. monocytogenes into Human Hepatocytes

(2011) Stephen Vadia et al.   PLoS Pathogens

A Population Genetics-Based and Phylogenetic Approach to Understanding the Evolution of Virulence in the Genus Listeria

(2010) H. C. den Bakker et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Phospholipid Hydrolysis Caused byClostridium perfringensα-Toxin Facilitates the Targeting of Perfringolysin O to Membrane Bilayers

(2010) Paul C. Moe et al.   BIOCHEMISTRY

Perfringolysin O Association with Ordered Lipid Domains: Implications for Transmembrane Protein Raft Affinity

(2010) Lindsay D. Nelson et al.   BIOPHYSICAL JOURNAL

Listeria monocytogenes impairs SUMOylation for efficient infection

(2010) David Ribet et al.   NATURE

Listeriolysin O Is Necessary and Sufficient to Induce Autophagy during Listeria monocytogenes Infection

(2010) Nicole Meyer-Morse et al.   PLoS One

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

(2010) A. J. Farrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of cytotoxin protein suilysin from Streptococcus suis

(2010) Lingfeng Xu et al.   Protein & Cell

Cholesterol Exposure at the Membrane Surface Is Necessary and Sufficient to Trigger Perfringolysin O Binding

(2009) John J. Flanagan et al.   BIOCHEMISTRY

Listeria monocytogenesPhosphatidylinositol-Specific Phospholipase C: Kinetic Activation and Homing in on Different Interfaces†

(2009) Wei Chen et al.   BIOCHEMISTRY

End-products diacylglycerol and ceramide modulate membrane fusion induced by a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa

(2009) Maitane Ibarguren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Listeria monocytogenesinternalin and E-cadherin: from structure to pathogenesis

(2009) Matteo Bonazzi et al.   CELLULAR MICROBIOLOGY

Listeriosis: a resurgent foodborne infection

(2009) F. Allerberger et al.   CLINICAL MICROBIOLOGY AND INFECTION

Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted byBacillus anthracis

(2009) Raymond W. Bourdeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Listeriosis: a primer

(2008) R. Bortolussi   CANADIAN MEDICAL ASSOCIATION JOURNAL

The MACPF/CDC family of pore-forming toxins

(2008) Carlos J. Rosado et al.   CELLULAR MICROBIOLOGY

The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCβ

(2008) Mathilde A. Poussin et al.   MICROBIAL PATHOGENESIS

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

(2008) Cheryl L. Birmingham et al.   NATURE

GILT is a critical host factor for Listeria monocytogenes infection

(2008) Reshma Singh et al.   NATURE

Exit strategies of intracellular pathogens

(2008) Kevin Hybiske et al.   NATURE REVIEWS MICROBIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY