Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Tamoxifen resistance: From bench to bedside

(2013) Marjolein Droog et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of PTPN2 and its use as a biomarker

(2013) Stéphanie Bussières-Marmen et al.   METHODS

Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit

(2012) Josefine Bostner et al.   BREAST CANCER RESEARCH AND TREATMENT

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

(2012) Benjamin J. Shields et al.   MOLECULAR AND CELLULAR BIOLOGY

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

(2012) Karin Beelen et al.   Nature Reviews Clinical Oncology

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

(2011) A. Goldhirsch et al.   ANNALS OF ONCOLOGY

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

(2011) M. Kleppe et al.   BLOOD

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1

(2011) Elin Karlsson et al.   GENES CHROMOSOMES & CANCER

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma

(2011) M. Kleppe et al.   HAEMATOLOGICA

Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer

(2011) Todd W. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion

(2010) Michael Scharl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

(2010) Elina Mattila et al.   BMC CANCER

Immunohistochemistry compared to cytosol assays for determination of estrogen receptor and prediction of the long-term effect of adjuvant tamoxifen

(2010) Mahmoud R. Khoshnoud et al.   BREAST CANCER RESEARCH AND TREATMENT

Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signaling by the protein tyrosine phosphatase TCPTP

(2010) Ben J. Shields et al.   CELL CYCLE

Protein tyrosine phosphatase N2 regulates TNF -induced signalling and cytokine secretion in human intestinal epithelial cells

(2010) M. Scharl et al.   GUT

Loss, mutation and deregulation of L3MBTL4 in breast cancers

(2010) Lynda Addou-Klouche et al.   Molecular Cancer

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells

(2009) Jasminka Omerovic et al.   BIOCHEMICAL JOURNAL

Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma

(2009) Chun-Feng Lee et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

(2008) E. Mattila et al.   JOURNAL OF CELL SCIENCE