Review
Pharmacology & Pharmacy
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen
Summary: Hyperactivation of the PI3K/AKT/mTOR pathway is associated with drug resistance and cancer progression in breast cancer patients. Current research is focusing on developing drugs targeting this pathway to overcome acquired resistance to standard therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniela Miricescu, Alexandra Totan, Iulia-Ioana Stanescu-Spinu, Silviu Constantin Badoiu, Constantin Stefani, Maria Greabu
Summary: Breast cancer is a complex disease with various factors contributing to its pathogenesis. Current research is focused on the PI3K/AKT/mTOR signaling pathway and related cancer mutations. Clinical trials are also evaluating the efficacy of inhibitors targeting these signaling pathways in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Esmael Besufikad Belachew, Dareskedar Tsehay Sewasew
Summary: The estrogen receptor is crucial in the treatment of estrogen receptor-positive breast cancer, with endocrine resistance posing a challenge. Combining drugs that target different signaling pathways and coregulatory proteins with endocrine therapy may offer a novel therapeutic approach to combat endocrine resistance.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thu Ha Pham, Yann Le Page, Frederic Percevault, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Apigenin shows therapeutic potential in treating endocrine-resistant breast cancer by inhibiting the Akt/FOXM1 signaling pathway and altering the expression of cell cycle-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Nicole Mavingire, Petreena Campbell, Jonathan Wooten, Joyce Aja, Melissa B. Davis, Andrea Loaiza-Perez, Eileen Brantley
Summary: Breast cancer stem cells (BCSCs) play a role in promoting endocrine therapy resistance through signaling cascades such as Notch, HIF, and integrin/Akt. Understanding these mechanisms can potentially lead to targeted therapy strategies to counteract endocrine resistance in HR positive breast cancer patients. Additionally, exploring the link between BCSC-regulatory gene levels and reduced survival in African American women with basal-like breast cancer may provide insights for improving clinical outcomes in this population.
Review
Biochemistry & Molecular Biology
Benoite Mery, Coralie Poulard, Muriel Le Romancer, Olivier Tredan
Summary: The AKT protein kinase has a key role in breast cancer, particularly in hormone receptor-positive breast cancer, where hyperactivation of the PI3K/AKT signaling pathway leads to treatment resistance. AKT inhibitors and PI3K/mTOR inhibitors have been developed and approved for the treatment of this type of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Zheqi Li, Tianqin Li, Megan E. Yates, Yang Wu, Amanda Ferber, Lyuqin Chen, Daniel D. Brown, Jason S. Carroll, Matthew J. Sikora, George C. Tseng, Steffi Oesterreich, Adrian V. Lee
Summary: The EstroGene database was established to analyze the activation of estrogen receptor -a (ER/ESR1) in breast cancer cell lines. It provides a user-friendly browser for gene inquiry and data visualization. The study revealed bidirectional E2 regulation in certain genes and characterized the E2 response programs in MCF7 and T47D cell lines.
Article
Cell Biology
Zheng Li, Yaming Li, Dianwen Han, Xiaolong Wang, Chen Li, Tong Chen, Wenhao Li, Yiran Liang, Dan Luo, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: circRNA-SFMBT2 is highly expressed in ER+ breast cancer cells and is associated with tumor size growth and poor prognosis. It positively correlates with ERα protein level and promotes cell growth and tamoxifen resistance. Inhibiting circRNA-SFMBT2 expression may be a potential therapeutic strategy for breast cancer.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Lea Clusan, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer, the most common and deadliest cancer among women worldwide, is closely associated with estrogen signaling. Hormone therapy using antiestrogens is the standard treatment, but resistance inevitably occurs through various biological mechanisms. Understanding the estrogen pathway is crucial for the development of new therapies for hormone-dependent breast cancer. This mini-review summarizes the current literature on estrogen receptors in breast cancer, including their signalization, mechanisms of action, and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jicheng Tantai, Xufeng Pan, Yong Chen, Yuzhou Shen, Chunyu Ji
Summary: TRIM46 amplification is significantly associated with poor survival rate in lung adenocarcinoma (LUAD). Overexpression of wild type TRIM46 increases LUAD cell proliferation, glycolysis, and cisplatin resistance through increased ubiquitination of PHLPP2 and upregulation of p-AKT. The function of TRIM46 depends on its E3 ligase activity.
CELL DEATH & DISEASE
(2022)
Review
Genetics & Heredity
Ozge Saatci, Kim-Tuyen Huynh-Dam, Ozgur Sahin
Summary: Endocrine resistance in ER + breast cancer involves diverse mechanisms affecting signaling pathways and cellular processes. Current clinical strategies include inhibitors targeting various key molecules to improve treatment outcomes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Anastasia Kottorou, Aspasia Tzezou
Summary: Breast cancer, the most common cancer in women, poses a challenge in therapeutic management for hormone receptor-positive patients due to resistance mechanisms. Molecular mechanisms involved in endocrine resistance include changes in hormone receptor signaling, activation of parallel pathways, cell cycle regulator modifications, transcription factor activation, and stem cell activity changes. Epigenetic changes, such as DNA methylation, histone modifications, and ncRNAs alterations, play a pivotal role not only in breast cancer progression but also in resistance to endocrine therapy.
Review
Pharmacology & Pharmacy
Brianna Blakely, Seobum Shin, Kideok Jin
Summary: Estrogen receptor (ER) is the main transcription factor in 75% of breast cancers, targeted by endocrine therapies. However, drug resistance is common. Frequent ESR1 mutations are found in metastatic tumors and ctDNA derived from ER positive breast cancer patients. The mechanisms of resistance and potential therapeutic targets in advanced breast cancer remain unclear. The tumor microenvironment (TME) is important in endocrine therapy resistance and breast cancer metastasis. This article reviews recent progress in endocrine therapy and the role of TME in ER positive breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Oncology
Covadonga Marti, Jose Ignacio Sanchez-Mendez
Summary: Treatment of breast cancer has evolved towards individualized management, with hormone therapy playing a key role. Neoadjuvant endocrine therapy has become an effective approach for many hormone receptor-positive breast cancers.
Review
Oncology
Ryan M. Finnegan, Ahmed M. Elshazly, Patricia Schoenlein, David A. Gewirtz
Summary: This article reviews the relationship between endocrine therapies and autophagy, exploring the different functional roles of autophagy in response to these treatments. It is found that autophagy can have cytoprotective, non-protective, cytostatic, or cytotoxic effects on tumor cells, suggesting its potential as an adjuvant therapeutic modality for endocrine therapies.
Article
Oncology
Cynthia Veenstra, Gizeh Perez-Tenorio, Anna Stelling, Elin Karlsson, Sanam Mirwani Mirwani, Bo Nordenskoljd, Tommy Fornander, Olle Stal
Article
Oncology
Elin Karlsson, Cynthia Veenstra, Jon Garsjo, Bo Nordenskjold, Tommy Fornander, Olle Stal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Article
Oncology
Sander Ellegard, Cynthia Veenstra, Gizeh Perez-Tenorio, Victor Fagerstrom, Jon Garsjo, Krista Gert, Marie Sundquist, Annika Malmstrom, Sten Wingren, Nils O. Elander, Anna-Lotta Hallbeck, Olle Stal
Article
Oncology
Cynthia Veenstra, Elin Karlsson, Sanam Mirwani Mirwani, Bo Nordenskjold, Tommy Fornander, Gizeh Perez-Tenorio, Olle Stal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)