In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

(2020) Cody Freedman et al.   BIOCHEMISTRY

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-Lipoxygenase-2 in biosynthesis of resolvin D5

(2020) Steven C Perry et al.   JOURNAL OF LIPID RESEARCH

Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1

(2020) Steven C. Perry et al.   BIOCHEMISTRY

Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX

(2020) Michel Lagarde et al.   BIOCHIMIE

Omega-6 DPA and its 12-lipoxygenase–oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner

(2020) Jennifer Yeung et al.   Blood Advances

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

(2019) Trond Vidar Hansen et al.   Frontiers in Pharmacology

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

(2019) Patricia R. Souza et al.   CIRCULATION RESEARCH

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly

(2018) Supakanya Wongrakpanich et al.   Aging and Disease

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

Biological relevance of double lipoxygenase products of polyunsaturated fatty acids, especially within blood vessels and brain

(2018) Michel Guichardant et al.   BIOCHIMIE

5S,15S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1

(2018) Abigail R. Green et al.   BIOCHEMISTRY

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential

(2016) Abigail R. Green et al.   BIOCHEMISTRY

5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

(2016) Jana Gerstmeier et al.   FASEB JOURNAL

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Bioactive products formed in humans from fish oils

(2015) Carsten Skarke et al.   JOURNAL OF LIPID RESEARCH

Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages

(2015) Marius Aursnes et al.   JOURNAL OF NATURAL PRODUCTS

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway

(2014) Robert Fischer et al.   JOURNAL OF LIPID RESEARCH

Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

(2014) Rosalina Wisastra et al.   Cancers

Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date

(2013) Laurence Balas et al.   BIOCHIMIE

Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase

(2013) Eleanor P. Dobson et al.   JOURNAL OF LIPID RESEARCH

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

(2012) Kenneth N. Ikei et al.   JOURNAL OF LIPID RESEARCH

Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation

(2010) Ping Chen et al.   FASEB JOURNAL

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation

(2009) P. Chen et al.   FEBS LETTERS

Substrate Specificity Changes for Human Reticulocyte and Epithelial 15-Lipoxygenases Reveal Allosteric Product Regulation†

(2008) Aaron T. Wecksler et al.   BIOCHEMISTRY

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

(2008) Nicolas G. Bazan   JOURNAL OF LIPID RESEARCH