Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1αexpression in human colon cancer cells

(2014) Yuanqing Wu et al.   Cancer Medicine

15-Lipoxygenase Promotes Chronic Hypoxia–Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-κB

(2013) Jing Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Catalytic asymmetric total synthesis of (S)-(−)-zearalenone, a novel lipoxygenase inhibitor

(2013) Marc P. Baggelaar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection

(2013) Rosalina Wisastra et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells

(2012) Yu Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

(2012) Rosalina Wisastra et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Interplay Between Inflammation and Oxidative Stress in Carcinogenesis

(2012) S. Nowsheen et al.   CURRENT MOLECULAR MEDICINE

Involvement of 15-lipoxygenase in the inflammatory arthritis

(2012) Ming-Yueh Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

(2012) Kenneth N. Ikei et al.   JOURNAL OF LIPID RESEARCH

Crystal Structure of 12-Lipoxygenase Catalytic-Domain-Inhibitor Complex Identifies a Substrate-Binding Channel for Catalysis

(2012) Shu Xu et al.   STRUCTURE

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

(2011) Dontscho Kerjaschki et al.   JOURNAL OF CLINICAL INVESTIGATION

Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist?

(2011) Gregory R. Tintinger et al.   TheScientificWorldJOURNAL

A systems biology approach to synovial joint lubrication in health, injury, and disease

(2011) Alexander Y. Hui et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Structural studies of NF-κB signaling

(2010) Chao Zheng et al.   CELL RESEARCH

5-Lipoxygenase inhibitors: a review of recent developments and patents

(2010) Carlo Pergola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Leukotriene B4Augments and Restores FcγRs-dependent Phagocytosis in Macrophages

(2010) Fuyuki Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Δ9-Tetrahydrocannabinol and Its Major Metabolite Δ9-Tetrahydrocannabinol-11-oic Acid as 15-Lipoxygenase Inhibitors

(2010) Shuso Takeda et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

RETRACTED ARTICLE: Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites

(2010) Mireille Basselin et al.   NEUROCHEMICAL RESEARCH

Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence

(2010) M V Suraneni et al.   ONCOGENE

15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells

(2009) Cheng Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoylclusters

(2009) Jérémie Doiron et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis

(2009) Magnus Back   CURRENT PHARMACEUTICAL DESIGN

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

(2009) Karina Roxana Gheorghe et al.   ARTHRITIS RESEARCH & THERAPY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Montelukast inhibits tumour necrosis factor-α-mediated interleukin-8 expression through inhibition of nuclear factor-κB p65-associated histone acetyltransferase activity

(2008) F. Tahan et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Urinary leukotriene E4 excretion: A biomarker of inflammatory bowel disease activity

(2008) Françoise Stanke-Labesque et al.   INFLAMMATORY BOWEL DISEASES

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

(2008) J EVANS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES