Understanding of sarcopenia: from definition to therapeutic strategies

Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

(2021) Roberta Sartori et al.   Nature Communications

Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults

(2020) Robert A Standley et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

(2020) Shuang Rong et al.   Journal of Cachexia Sarcopenia and Muscle

Isokinetic testing of muscle strength of older individuals with sarcopenia or frailty: A systematic review

(2020) Michal Steffl et al.   ISOKINETICS AND EXERCISE SCIENCE

Branched chain amino acids, aging and age-related health

(2020) David G. Le Couteur et al.   AGEING RESEARCH REVIEWS

Grip Work Measurement with the Jamar Dynamometer: Validation of a Simple Equation for Clinical Use

(2019) L. de Dobbeleer et al.   Journal of Nutrition Health & Aging

Sarcopenia: revised European consensus on definition and diagnosis

(2019) Alfonso J Cruz-Jentoft et al.   AGE AND AGEING

Prevalence and overlap of sarcopenia, frailty, cachexia and malnutrition in older medical inpatients

(2019) Anne Gingrich et al.   BMC Geriatrics

Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70

(2019) Hyeon-Ju Jeong et al.   CELL DEATH AND DIFFERENTIATION

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

(2019) Pei Zhu et al.   Nature Communications

Testosterone supplementation improves insulin responsiveness in HFD fed male T2DM mice and potentiates insulin signaling in the skeletal muscle and C2C12 myocyte cell line

(2019) Madhuraka Pal et al.   PLoS One

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

(2019) Liqing Luo et al.   Cell Reports

Does nutrition play a role in the prevention and management of sarcopenia?

(2018) S.M. Robinson et al.   CLINICAL NUTRITION

Bioelectrical impedance analysis in the assessment of sarcopenia

(2018) M. Cristina Gonzalez et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Role of Oral Nutritional Supplements Enriched with B-hydroxy-B-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings

(2018) Alejandro Sanz-Paris et al.   Journal of Nutrition Health & Aging

Association between handgrip strength, balance, and knee flexion/extension strength in older adults

(2018) Angelica Castilho Alonso et al.   PLoS One

Knee extension rate of torque development and peak torque: associations with lower extremity function

(2018) Yusuke Osawa et al.   Journal of Cachexia Sarcopenia and Muscle

Pitfalls in the measurement of muscle mass: a need for a reference standard

(2018) Fanny Buckinx et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenia: assessment of disease burden and strategies to improve outcomes

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses

(2018) Eva Pigna et al.   Skeletal Muscle

Age-related changes in skeletal muscle: changes to life-style as a therapy

(2018) Rachel McCormick et al.   BIOGERONTOLOGY

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

Muscle Ultrasound and Sarcopenia in Older Individuals: A Clinical Perspective

(2017) Andrea Ticinesi et al.   Journal of the American Medical Directors Association

Epidemiology of sarcopenia and insight into possible therapeutic targets

(2017) Elaine M. Dennison et al.   Nature Reviews Rheumatology

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

(2017) Frederic Morvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PASE (Physical Activity Scale for the Elderly) Score Is Related to Sarcopenia in Noninstitutionalized Older Adults

(2017) Francesco Curcio et al.   Journal of Geriatric Physical Therapy

Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo

(2016) Nelly Béchir et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physical activity in older age: perspectives for healthy ageing and frailty

(2016) Jamie S. McPhee et al.   BIOGERONTOLOGY

Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis

(2016) Rita Pavasini et al.   BMC Medicine

Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation

(2016) Verawan Boonsanay et al.   Cell Stem Cell

Growth Factors for Skeletal Muscle Tissue Engineering

(2016) Brian C. Syverud et al.   CELLS TISSUES ORGANS

Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease

(2016) Albert E. Almada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic control of adult stem cell function

(2016) Alexandra Avgustinova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differentiating Sarcopenia and Cachexia Among Patients With Cancer

(2016) Sarah J. Peterson et al.   NUTRITION IN CLINICAL PRACTICE

Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study

(2016) Richard Matthew Dodds et al.   Journal of Cachexia Sarcopenia and Muscle

Fatty Infiltration of Skeletal Muscle: Mechanisms and Comparisons with Bone Marrow Adiposity

(2016) Mark W. Hamrick et al.   Frontiers in Endocrinology

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

(2016) Giorgos K. Sakellariou et al.   Scientific Reports

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

(2015) Michael E. Walsh et al.   AGING CELL

Fish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults1

(2015) Gordon I Smith et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors 

(2015) David C. Hughes et al.   BIOGERONTOLOGY

Grip strength measured by high precision dynamometry in healthy subjects from 5 to 80 years

(2015) Jean-Yves Hogrel   BMC MUSCULOSKELETAL DISORDERS

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

Protein intake and muscle function in older adults

(2015) Rachel R. Deer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice

(2015) Maxim V. Ivannikov et al.   FREE RADICAL BIOLOGY AND MEDICINE

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

The central role of muscle stem cells in regenerative failure with aging

(2015) Helen M Blau et al.   NATURE MEDICINE

Age-Specific Functional Epigenetic Changes in p21 and p16 in Injury-Activated Satellite Cells

(2015) Ju Li et al.   STEM CELLS

Prmt5 is a regulator of muscle stem cell expansion in adult mice

(2015) Ting Zhang et al.   Nature Communications

Biomarkers for physical frailty and sarcopenia: state of the science and future developments

(2015) Riccardo Calvani et al.   Journal of Cachexia Sarcopenia and Muscle

Endocrine determinants of incident sarcopenia in middle-aged and elderly European men

(2015) Evelien Gielen et al.   Journal of Cachexia Sarcopenia and Muscle

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation

(2014) Shelley DE Sandiford et al.   Cell Communication and Signaling

Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways

(2014) J. Rodriguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucocorticoids increase adipocytes in muscle by affecting IL-4 regulated FAP activity

(2014) Yanjun Dong et al.   FASEB JOURNAL

Sarcopenia, Cachexia and Aging: Diagnosis, Mechanisms and Therapeutic Options - A Mini-Review

(2014) Sumbul Ali et al.   GERONTOLOGY

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

(2014) A. W. Beharry et al.   JOURNAL OF CELL SCIENCE

Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia

(2014) Liang-Kung Chen et al.   Journal of the American Medical Directors Association

The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates

(2014) Stephanie A. Studenski et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High Whey Protein Intake Delayed the Loss of Lean Body Mass in Healthy Old Rats, whereas Protein Type and Polyphenol/Antioxidant Supplementation Had No Effects

(2014) Laurent Mosoni et al.   PLoS One

Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibers at rest, but not during contractions

(2013) Jesus Palomero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

(2013) Gilles Gouspillou et al.   FASEB JOURNAL

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

Prevalence and Clinical Correlates of Sarcopenia in Community-Dwelling Older People: Application of the EWGSOP Definition and Diagnostic Algorithm

(2013) S. Volpato et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis

(2013) Pedro Cisternas et al.   MOLECULAR NEUROBIOLOGY

Skeletal muscle autophagy: a new metabolic regulator

(2013) Brian A. Neel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Cultured senescent myoblasts derived from human vastus lateralis exhibit normal mitochondrial ATP synthesis capacities with correlating concomitant ROS production while whole cell ATP production is decreased

(2012) Ariane D. Minet et al.   BIOGERONTOLOGY

Myostatin inhibits myosatellite cell proliferation and consequently activates differentiation: evidence for endocrine-regulated transcript processing

(2012) Dilip K Garikipati et al.   JOURNAL OF ENDOCRINOLOGY

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

Frailty and sarcopenia: definitions and outcome parameters

(2012) C. Cooper et al.   OSTEOPOROSIS INTERNATIONAL

Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation

(2012) B. M. T. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Building Muscle: Molecular Regulation of Myogenesis

(2012) C. F. Bentzinger et al.   Cold Spring Harbor Perspectives in Biology

Role and potential mechanisms of anabolic resistance in sarcopenia

(2012) Prashanth H. Haran et al.   Journal of Cachexia Sarcopenia and Muscle

A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach

(2011) Helen C. Roberts et al.   AGE AND AGEING

Sarcopenia With Limited Mobility: An International Consensus

(2011) John E. Morley et al.   Journal of the American Medical Directors Association

Dynapenia and Aging: An Update

(2011) Todd M. Manini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The role of myostatin in muscle wasting: an overview

(2011) Yulia Elkina et al.   Journal of Cachexia Sarcopenia and Muscle

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

(2011) James T. Dalton et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People

(2010) A. J. Cruz-Jentoft et al.   AGE AND AGEING

Resistance exercise for muscular strength in older adults: A meta-analysis

(2010) Mark D. Peterson et al.   AGEING RESEARCH REVIEWS

Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy

(2010) Marco Sandri   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles

(2010) Eva Masiero et al.   Autophagy

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Muscle stem cells in developmental and regenerative myogenesis

(2010) Jong-Sun Kang et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Oxidative Stress, Molecular Inflammation and Sarcopenia

(2010) Si-Jin Meng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of hand dynamometers in elderly people

(2010) R. S. Guerra et al.   Journal of Nutrition Health & Aging

Inflammatory Markers and Physical Performance Among Nonagenarians

(2010) K. Tiainen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effects of Testosterone on Skeletal Muscle Architecture in Intermediate-Frail and Frail Elderly Men

(2010) R. A. Atkinson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Influence of Resistance Exercise on Lean Body Mass in Aging Adults

(2010) MARK D. PETERSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

An overview of sarcopenia: facts and numbers on prevalence and clinical impact

(2010) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging

(2009) Monica Fuente et al.   CURRENT PHARMACEUTICAL DESIGN

Is grip strength a predictor for total muscle strength in healthy children, adolescents, and young adults?

(2009) Anne E. Wind et al.   EUROPEAN JOURNAL OF PEDIATRICS

Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats

(2009) Isabelle Rieu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cdo Binds Abl To Promote p38 /  Mitogen-Activated Protein Kinase Activity and Myogenic Differentiation

(2009) G.-U. Bae et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of ubiquitin-proteasome proteolysis in muscle fiber destruction in experimental chloroquine-induced myopathy

(2009) Noriyuki Kimura et al.   MUSCLE & NERVE

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading

(2009) Anna E. Thalacker-Mercer et al.   PHYSIOLOGICAL GENOMICS

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

(2008) Melissa Braga et al.   APOPTOSIS

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Reproducibility of an Isokinetic Strength-Testing Protocol of the Knee and Ankle in Older Adults

(2008) Antonia Hartmann et al.   GERONTOLOGY

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

(2008) Emanuele Marzetti et al.   MECHANISMS OF AGEING AND DEVELOPMENT