Versatile CRISPR-Cas12a-Based Biosensing Platform Modulated with Programmable Entropy-Driven Dynamic DNA Networks

Cas12aFDet: a CRISPR/Cas12a-based fluorescence platform for sensitive and specific detection of Listeria monocytogenes serotype 4c

(2021) Fan Li et al.   ANALYTICA CHIMICA ACTA

Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Lateral Flow Nucleic Acid Assay

(2020) Xusheng Wang et al.   ACS Nano

Universal and Naked-Eye Gene Detection Platform Based on the Clustered Regularly Interspaced Short Palindromic Repeats/Cas12a/13a System

(2020) Chaoqun Yuan et al.   ANALYTICAL CHEMISTRY

Performing Fuzzy DNA Strand Displacement Using Polymerases

(2020) Zhiyu Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ultra-sensitive and high-throughput CRISPR-Powered COVID-19 diagnosis

(2020) Zhen Huang et al.   BIOSENSORS & BIOELECTRONICS

CRISPR/Cas13a Powered Portable Electrochemiluminescence Chip for Ultrasensitive and Specific MiRNA Detection

(2020) Ting Zhou et al.   Advanced Science

Applying CRISPR-Cas12a as a Signal Amplifier to Construct Biosensors for Non-DNA Targets in Ultralow Concentrations

(2020) Junjie Li et al.   ACS Sensors

A Methodology for Ultrasensitive Detection of Sequence-Specific DNA or Uracil-DNA Glycosylase Activity

(2020) Xiaolong Chen et al.   ACS Sensors

Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)

(2020) Reza Nouri et al.   ACS Sensors

DNA Tetrahedra Modules as Versatile Optical Sensing Platforms for Multiplexed Analysis of miRNAs, Endonucleases, and Aptamer–Ligand Complexes

(2020) Zhixin Zhou et al.   ACS Nano

CRISPR/cas systems redefine nucleic acid detection: Principles and methods

(2020) Meng Wang et al.   BIOSENSORS & BIOELECTRONICS

A versatile biosensing platform coupling CRISPR–Cas12a and aptamers for detection of diverse analytes

(2020) Xiangxiang Zhao et al.   Science Bulletin

MNAzyme-Catalyzed Amplification Assay with Lanthanide Tags for the Simultaneous Detection of Multiple microRNAs by Inductively Coupled Plasma–Mass Spectrometry

(2020) Qi Kang et al.   ANALYTICAL CHEMISTRY

Terminal deoxynucleotidyl transferase combined CRISPR-Cas12a amplification strategy for ultrasensitive detection of uracil-DNA glycosylase with zero background

(2020) Yi-Chen Du et al.   BIOSENSORS & BIOELECTRONICS

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a

(2019) Daan C. Swarts et al.   MOLECULAR CELL

An aptamer-based hook-effect-recognizable three-line lateral flow biosensor for rapid detection of thrombin

(2019) Ya Gao et al.   BIOSENSORS & BIOELECTRONICS

A NIR Light Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals

(2019) Jian Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrocatalytic Efficiency Regulation between Target-Induced HRP-Mimicking DNAzyme and GOx with Low Background for Ultrasensitive Detection of Thrombin

(2019) Lingqi Kong et al.   ANALYTICAL CHEMISTRY

Small molecule electro-optical binding assay using nanopores

(2019) Shenglin Cai et al.   Nature Communications

CRISPR-mediated live imaging of genome editing and transcription

(2019) Haifeng Wang et al.   SCIENCE

Programmable CRISPR-responsive smart materials

(2019) Max A. English et al.   SCIENCE

CRISPR/Cas13a‐Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification‐Free miRNA Diagnostics

(2019) Richard Bruch et al.   ADVANCED MATERIALS

Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation

(2019) Lianhui Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

(2019) Mindong Liang et al.   Nature Communications

Rolling Circular Amplification (RCA)-Assisted CRISPR/Cas9 Cleavage (RACE) for Highly Specific Detection of Multiple Extracellular Vesicle MicroRNAs

(2019) Ruixuan Wang et al.   ANALYTICAL CHEMISTRY

DNA Origami Post-Processing by CRISPR-Cas12a

(2019) Qiancheng Xiong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid and reagentless detection of thrombin in clinic samples via microfluidic aptasensors with multiple target-binding sites

(2019) Neng Yu et al.   BIOSENSORS & BIOELECTRONICS

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

(2019) Ying Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

(2018) Shi-Yuan Li et al.   CELL RESEARCH

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Target binding and DNA hybridization-induced gold nanoparticle aggregation for colorimetric detection of thrombin

(2018) Li Li et al.   SENSORS AND ACTUATORS B-CHEMICAL

Label-free fluorescent aptasensor for thrombin detection based on exonuclease I assisted target recycling and SYBR Green I aided signal amplification

(2018) Xiaolan Chen et al.   SENSORS AND ACTUATORS B-CHEMICAL

Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit

(2018) Jeffrey D. Munzar et al.   Nature Communications

Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

(2018) Yongmoon Jeon et al.   Nature Communications

CRISPR-Cas12a-assisted nucleic acid detection

(2018) Shi-Yuan Li et al.   Cell Discovery

Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

(2018) Stefano Stella et al.   CELL

CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing

(2017) Miguel A. Moreno-Mateos et al.   Nature Communications

Aptamer-based FRET nanoflares for imaging potassium ions in living cells

(2016) Yanjing Yang et al.   CHEMICAL COMMUNICATIONS

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Aptamer binding assays for proteins: The thrombin example—A review

(2014) Bin Deng et al.   ANALYTICA CHIMICA ACTA

A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions

(2012) Da Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

(2008) Z Lu et al.   ONCOGENE