Proline metabolism in cancer

PYCR1 promotes bladder cancer by affecting the Akt/Wnt/β-catenin signaling

(2021) Shuangkuan Du et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial NADP(H) generation is essential for proline biosynthesis

(2021) Jiajun Zhu et al.   SCIENCE

PYCR, a key enzyme in proline metabolism, functions in tumorigenesis

(2021) Yutong Li et al.   AMINO ACIDS

Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth

(2020) Miao Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer progression is mediated by proline catabolism in non-small cell lung cancer

(2020) Yating Liu et al.   ONCOGENE

Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis

(2020) Un Yung Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P4HB modulates epithelial‑mesenchymal transition and the β‑catenin/Snail pathway influencing chemoresistance in liver cancer cells

(2020) Xing Ma et al.   Oncology Letters

Targeted Inhibition of P4HB Promotes Cell Sensitivity to Gemcitabine in Urothelial Carcinoma of the Bladder

(2020) Xiaoming Wang et al.   OncoTargets and Therapy

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

(2020) Ling Guo et al.   Nature Communications

Kindlin-2 links mechano-environment to proline synthesis and tumor growth

(2019) Ling Guo et al.   Nature Communications

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

Pyrroline-5-Carboxylate Reductase 1 Accelerates the Migration and Invasion of Nonsmall Cell Lung Cancer In Vitro

(2019) Senhua Sang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Collagen prolyl hydroxylation-dependent metabolic perturbation governs epigenetic remodeling and mesenchymal transition in pluripotent and cancer cells

(2019) Cristina D'Aniello et al.   CANCER RESEARCH

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

(2019) Shuaiyi Chen et al.   NEOPLASIA

P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer

(2019) X.P. Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of collagen in cancer: from bench to bedside

(2019) Shuaishuai Xu et al.   Journal of Translational Medicine

Therapeutic Targeting of MZF1‐AS1 /PARP1/E2F1 Axis Inhibits Proline Synthesis and Neuroblastoma Progression

(2019) Erhu Fang et al.   Advanced Science

Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis

(2019) Zhaobing Ding et al.   JOURNAL OF HEPATOLOGY

PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer

(2019) Juhua Zhuang et al.   Journal of Translational Medicine

In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine

(2018) Mark P. S. Dunphy et al.   RADIOLOGY

Ornithine aminotransferase promoted the proliferation and metastasis of non‐small cell lung cancer via upregulation of miR‐21

(2018) Yanfeng Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling

(2018) Ying Zhou et al.   Molecular Medicine Reports

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

(2018) Gaofeng Xiong et al.   Nature Communications

PYCR1 promotes the progression of non-small-cell lung cancer under the negative regulation of miR-488

(2018) Dongchang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer

(2017) Tengyue Zeng et al.   MEDICAL ONCOLOGY

Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer

(2017) Feng Cai et al.   Oncology Letters

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

(2017) Cristina D'Aniello et al.   Stem Cells International

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

(2016) Wei Xia et al.   Oncotarget

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

(2015) G. R. Kardos et al.   MOLECULAR CANCER RESEARCH

Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway

(2015) Rongying Ou et al.   TUMOR BIOLOGY

Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase

(2015) Ehud Zigmond et al.   ACS Medicinal Chemistry Letters

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production

(2015) Yosuke Togashi et al.   Oncotarget

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

(2014) Gaofeng Xiong et al.   BMC CANCER

DJ-1 cooperates with PYCR1 in cell protection against oxidative stress

(2013) Tatsuki Yasuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

(2013) D. M. Gilkes et al.   CANCER RESEARCH

L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

(2013) Stefania Comes et al.   Stem Cell Reports

Proline dehydrogenase (oxidase) in cancer

(2012) Wei Liu et al.   BIOFACTORS

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments

(2012) W. Liu et al.   CANCER RESEARCH

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

(2012) Sathish Kumar Natarajan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Metabonomics and its role in amino acid nutrition research

(2011) Qinghua He   Frontiers in Bioscience-Landmark

Proline metabolism and cancer

(2011) James et al.   Frontiers in Bioscience-Landmark

miR-23b* targets proline oxidase, a novel tumor suppressor protein in renal cancer

(2010) W Liu et al.   ONCOGENE

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers

(2009) Y. Liu et al.   CANCER RESEARCH

Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy

(2009) O. Zabirnyk et al.   CARCINOGENESIS

Regulation and function of proline oxidase under nutrient stress

(2009) Jui Pandhare et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human Δ1-pyrroline-5-carboxylate synthase: function and regulation

(2008) C.-A. A. Hu et al.   AMINO ACIDS

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers

(2008) Y Liu et al.   ONCOGENE