Genomic partitioning of inbreeding depression in humans

De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population

(2020) Michael D. Kessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic basis of inbreeding depression in potato

(2019) Chunzhi Zhang et al.   NATURE GENETICS

Characterizing mutagenic effects of recombination through a sequence-level genetic map

(2019) Bjarni V. Halldorsson et al.   SCIENCE

Disease Heritability Enrichment of Regulatory Elements Is Concentrated in Elements with Ancient Sequence Age and Conserved Function across Species

(2019) Margaux L.A. Hujoel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Extreme inbreeding in a European ancestry sample from the contemporary UK population

(2019) Loic Yengo et al.   Nature Communications

Associations of autozygosity with a broad range of human phenotypes

(2019) David W Clark et al.   Nature Communications

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

(2018) Farhad Hormozdiari et al.   NATURE GENETICS

Runs of homozygosity: windows into population history and trait architecture

(2018) Francisco C. Ceballos et al.   NATURE REVIEWS GENETICS

Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

(2018) Loic Yengo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

(2018) Pier Francesco Palamara et al.   NATURE GENETICS

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

(2018) Steven Gazal et al.   NATURE GENETICS

Relationships between estimated autozygosity and complex traits in the UK Biobank

(2018) Emma C. Johnson et al.   PLoS Genetics

Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences

(2018) Fanny Pouyet et al.   eLife

SLiM 3: Forward Genetic Simulations Beyond the Wright–Fisher Model

(2018) Benjamin C Haller et al.   MOLECULAR BIOLOGY AND EVOLUTION

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Genome-wide mapping and estimation of inbreeding depression of semen quality traits in a cattle population

(2017) Maja Ferenčaković et al.   JOURNAL OF DAIRY SCIENCE

Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection

(2017) Steven Gazal et al.   NATURE GENETICS

Detection and quantification of inbreeding depression for complex traits from SNP data

(2017) Loic Yengo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inbreeding depression by environment interactions in a free-living mammal population

(2016) J M Pemberton et al.   HEREDITY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Inbreeding depression across the lifespan in a wild mammal population

(2016) Jisca Huisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

(2016) Emma C. Johnson et al.   PLoS Genetics

Nucleotide diversity analysis highlights functionally important genomic regions

(2016) Tatiana V. Tatarinova et al.   Scientific Reports

Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages

(2015) Paraskevi Christofidou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

(2015) Zhihong Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enhancer Evolution across 20 Mammalian Species

(2015) Diego Villar et al.   CELL

Directional dominance on stature and cognition in diverse human populations

(2015) Peter K. Joshi et al.   NATURE

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Genomic analysis of hybrid rice varieties reveals numerous superior alleles that contribute to heterosis

(2015) Xuehui Huang et al.   Nature Communications

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

(2014) Alexander Gusev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inbreeding Coefficient Estimation with Dense SNP Data: Comparison of Strategies and Application to HapMap III

(2014) Steven Gazal et al.   HUMAN HEREDITY

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor

(2014) Matthew C. Keller et al.   PLoS Genetics

Genome-Wide Inference of Ancestral Recombination Graphs

(2014) Matthew D. Rasmussen et al.   PLoS Genetics

Long Runs of Homozygosity Are Enriched for Deleterious Variation

(2013) Zachary A. Szpiech et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Are transcriptional responses to inbreeding a functional response to alleviate inbreeding depression?

(2013) Carlos García et al.   FLY

Gene-Expression Changes Caused by Inbreeding Protect Against Inbreeding Depression in Drosophila

(2012) C. Garcia et al.   GENETICS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Integrative annotation of chromatin elements from ENCODE data

(2012) Michael M. Hoffman et al.   NUCLEIC ACIDS RESEARCH

Evidence of Inbreeding Depression on Human Height

(2012) Ruth McQuillan et al.   PLoS Genetics

UK Biobank: Current status and what it means for epidemiology

(2012) Naomi Allen et al.   Health Policy and Technology

Detecting autozygosity through runs of homozygosity: A comparison of three autozygosity detection algorithms

(2011) Daniel P Howrigan et al.   BMC GENOMICS

Quantification of Inbreeding Due to Distant Ancestors and Its Detection Using Dense Single Nucleotide Polymorphism Data

(2011) Matthew C. Keller et al.   GENETICS

A Jurassic eutherian mammal and divergence of marsupials and placentals

(2011) Zhe-Xi Luo et al.   NATURE

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++

(2010) Eugene V. Davydov et al.   PLoS Computational Biology

A Genomewide Assessment of Inbreeding Depression: Gene Number, Function, and Mode of Action

(2009) JULIEN F. AYROLES et al.   CONSERVATION BIOLOGY

The genetics of inbreeding depression

(2009) Deborah Charlesworth et al.   NATURE REVIEWS GENETICS

Widespread Genomic Signatures of Natural Selection in Hominid Evolution

(2009) Graham McVicker et al.   PLoS Genetics