Mitochondria: Their relevance during oocyte ageing

Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis

(2021) Francesco Ragonese et al.   FERTILITY AND STERILITY

The Regulation of Mitochondrial Replacement Techniques Around the World

(2020) I. Glenn Cohen et al.   Annual Review of Genomics and Human Genetics

Mitochondrial Dysfunction and Ovarian Aging

(2020) Işıl Kasapoğlu et al.   ENDOCRINOLOGY

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

(2020) Michael J. Bertoldo et al.   Cell Reports

The effect of rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance

(2020) Pawel Kordowitzki et al.   Aging-US

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

(2020) Minrui Fan et al.   NATURE

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

(2020) Beverly Y. Mok et al.   NATURE

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

(2020) Yilong Miao et al.   Cell Reports

Effect of mitophagy in oocytes and granulosa cells on oocyte quality†

(2020) Qiuzi Shen et al.   BIOLOGY OF REPRODUCTION

PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression

(2020) Daniel G. Corum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Does supplementation with mitochondria improve oocyte competence? A systematic review

(2020) Ana Filipa Ferreira et al.   REPRODUCTION

Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review

(2020) Cristina Rodríguez-Varela et al.   Antioxidants

Mitochondria as a tool for oocyte rejuvenation

(2019) Elena Labarta et al.   FERTILITY AND STERILITY

Melatonin supplementation during in vitro maturation of oocyte enhances subsequent development of bovine cloned embryos

(2019) Quanli An et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

(2019) Yan Wang et al.   CELL

New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer

(2019) Mauro Cozzolino et al.   Reproductive Biology and Endocrinology

Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve

(2019) Man Zhang et al.   Cell Death & Disease

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

(2019) Erfaneh Barati et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression

(2019) Tayaba Ismail et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of PPARGC1A on the development and metabolism of early rabbit embryos in vitro

(2019) Guo‐Min Zhang et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

(2019) Akshay Bareja et al.   Frontiers in Cell and Developmental Biology

Physician Fertility

(2019) Ariela L. Marshall et al.   ACADEMIC MEDICINE

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Postovulatory ageing modifies sperm-induced Ca2+ oscillations in mouse oocytes through a conditions-dependent, multi-pathway mechanism

(2019) Marcin Szpila et al.   Scientific Reports

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Rapamycin treatment maintains developmental potential of oocytes in mice and follicle reserve in human cortical fragments grafted into immune-deficient mice

(2019) Yorino Sato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

New insights into apoptosome structure and function

(2018) Loretta Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Symposium review: Reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function 1

(2018) Zvi Roth   JOURNAL OF DAIRY SCIENCE

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models

(2018) Cristina Mammucari et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

(2018) Payam A. Gammage et al.   TRENDS IN GENETICS

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress

(2018) Jiska van der Reest et al.   Nature Communications

Ca 2+ -Induced Mitochondrial ROS Regulate the Early Embryonic Cell Cycle

(2018) Yue Han et al.   Cell Reports

The Aging Mitochondria

(2018) Pierre Theurey et al.   Genes

Maternal anemia, iron intake in pregnancy, and offspring blood pressure in the Avon Longitudinal Study of Parents and Children

(2018) Marie-Jo A Brion et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

(2018) Anna Picca et al.   Nature Reviews Cardiology

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of the mitochondrial kinase PINK1 does not alter platelet function

(2018) Tony G. Walsh et al.   Scientific Reports

Does the use of calcium ionophore during artificial oocyte activation demonstrate an effect on pregnancy rate? A meta-analysis

(2017) Sughashini Murugesu et al.   FERTILITY AND STERILITY

Quantitative and qualitative changes of mitochondria in human preimplantation embryos

(2017) Shu Hashimoto et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live birth derived from oocyte spindle transfer to prevent mitochondrial disease

(2017) John Zhang et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Serine and Functional Metabolites in Cancer

(2017) Alice C. Newman et al.   TRENDS IN CELL BIOLOGY

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

(2017) Yi Liu et al.   Translational Neurodegeneration

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

Translational regulation of mitochondrial biogenesis

(2016) Y. Zhang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

(2016) Mitsutoshi Yamada et al.   Cell Stem Cell

Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity

(2016) Elnur Babayev et al.   MATURITAS

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Mitochondrial Replacement Techniques: Divergence in Global Policy

(2016) Johanna Schandera et al.   TRENDS IN GENETICS

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

(2015) Assaf Ben-Meir et al.   AGING CELL

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Gaining mass: the structure of respiratory complex I—from bacterial towards mitochondrial versions

(2015) James A Letts et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ultrastructural markers of quality are impaired in human metaphase II aged oocytes: a comparison between reproductive and in vitro aging

(2015) S. Bianchi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

(2015) Hua Zhang et al.   NATURE MEDICINE

Molecular insights into the aetiology of female reproductive ageing

(2015) John R. B. Perry et al.   Nature Reviews Endocrinology

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

Oogonial stem cells as a model to study age-associated infertility in women

(2015) Neha Garg et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Mitochondrial replacement therapy in reproductive medicine

(2015) Don P. Wolf et al.   TRENDS IN MOLECULAR MEDICINE

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

(2015) Areum Jo et al.   Biomed Research International

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Mitochondrial Proteostasis in the Control of Aging and Longevity

(2014) Martin Borch Jensen et al.   Cell Metabolism

Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles

(2014) Osamu Udagawa et al.   CURRENT BIOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Effect of oocyte donation on pregnancy outcomes in in vitro fertilization twin gestations

(2014) Lucky H. Sekhon et al.   FERTILITY AND STERILITY

Increased levels of oxidative and carbonyl stress markers in normal ovarian cortex surrounding endometriotic cysts

(2014) Giovanna Di Emidio et al.   GYNECOLOGICAL ENDOCRINOLOGY

The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology

(2014) Stephanie E. Wohlgemuth et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool—technicalities and possible risks

(2014) Lynsey Cree et al.   MOLECULAR HUMAN REPRODUCTION

Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

(2014) Jahda H Hill et al.   NATURE GENETICS

The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility

(2014) Heide Schatten et al.   Reproductive Biology and Endocrinology

Advancing maternal age predisposes to mitochondrial damage and loss during maturation of equine oocytes in vitro

(2014) B.P.B. Rambags et al.   THERIOGENOLOGY

The effect of mother’s age and other related factors on neonatal survival associated with first and second birth in rural, Tanzania: evidence from Ifakara health and demographic surveillance system in rural Tanzania

(2014) Majige Selemani et al.   BMC Pregnancy and Childbirth

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondrial genome function and maternal inheritance

(2013) John F. Allen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The control of mtDNA replication during differentiation and development

(2013) Justin St. John   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Germline Energetics, Aging, and Female Infertility

(2013) Jonathan L. Tilly et al.   Cell Metabolism

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Redox regulation of protein kinases

(2013) Thu H. Truong et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Metabolism throughout follicle and oocyte development in mammals

(2013) Esther Collado-Fernandez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

DNMT1 Is Regulated by ATP-Citrate Lyase and Maintains Methylation Patterns during Adipocyte Differentiation

(2013) T. Londono Gentile et al.   MOLECULAR AND CELLULAR BIOLOGY

Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes

(2013) Fatma Simsek-Duran et al.   PLoS One

Accessorizing the human mitochondrial transcription machinery

(2013) Megan L. Bestwick et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chromosome cohesion decreases in human eggs with advanced maternal age

(2012) Francesca E. Duncan et al.   AGING CELL

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Transmission, inheritance and replication of mitochondrial DNA in mammals: implications for reproductive processes and infertility

(2012) Justin C. St John   CELL AND TISSUE RESEARCH

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Melatonin as a free radical scavenger in the ovarian follicle [Review]

(2012) Hiroshi Tamura et al.   ENDOCRINE JOURNAL

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC)

(2012) Jinmiao Liu et al.   HUMAN REPRODUCTION

Oxidative Phosphorylation-linked Respiration in Individual Bovine Oocytes

(2012) Satoshi SUGIMURA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women

(2012) Yvonne A R White et al.   NATURE MEDICINE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular enzymology of 5-Aminolevulinate synthase, the gatekeeper of heme biosynthesis

(2011) Gregory A. Hunter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes1

(2011) Teresa Chiang et al.   BIOLOGY OF REPRODUCTION

Contribution of myo-inositol and melatonin to human reproduction

(2011) G. Carlomagno et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

The contribution of mitochondrial function to reproductive aging

(2011) Yaakov Bentov et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The Transcriptome of a Human Polar Body Accurately Reflects Its Sibling Oocyte

(2011) Adrian Reich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

Quantification and identification of mitochondrial proteins containing vicinal dithiols

(2010) Raquel Requejo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identification of NAD interacting residues in proteins

(2010) Hifzur R Ansari et al.   BMC BIOINFORMATICS

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Costs of infertility treatment: results from an 18-month prospective cohort study

(2010) Patricia Katz et al.   FERTILITY AND STERILITY

Gene expression profiles of single human mature oocytes in relation to age

(2010) M.L. Grøndahl et al.   HUMAN REPRODUCTION

Mitochondrial DNA transmission, replication and inheritance: a journey from the gamete through the embryo and into offspring and embryonic stem cells

(2010) J. C. St. John et al.   HUMAN REPRODUCTION UPDATE

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial function in the human oocyte and embryo and their role in developmental competence

(2010) Jonathan Van Blerkom   MITOCHONDRION

Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions

(2010) U. Eichenlaub-Ritter et al.   MITOCHONDRION

Somatic Point Mutations in mtDNA Control Region Are Influenced by Genetic Background and Associated with Healthy Aging: A GEHA Study

(2010) Giuseppina Rose et al.   PLoS One

Reexamination of a Meta-Analysis of the Effect of Antioxidant Supplementation on Mortality and Health in Randomized Trials

(2010) Hans K. Biesalski et al.   Nutrients

Quantification of mitochondrial DNA mutation load

(2009) Laura C. Greaves et al.   AGING CELL

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

(2009) Shin-ichiro Imai   CELL BIOCHEMISTRY AND BIOPHYSICS

Ethical Issues in Stem Cell Research

(2009) Bernard Lo et al.   ENDOCRINE REVIEWS

The mitochondrial citrate carrier: Metabolic role and regulation of its activity and expression

(2009) Gabriele V. Gnoni et al.   IUBMB LIFE

Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release

(2009) Lydia Lartigue et al.   MOLECULAR BIOLOGY OF THE CELL

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status

(2009) Halil Ciftci et al.   UROLOGY

Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age

(2008) Kaisa Selesniemi et al.   AGING CELL

Mitochondrial distribution and activity in human mature oocytes: gonadotropin-releasing hormone agonist versus antagonist for pituitary down-regulation

(2008) Maria Elena Dell'Aquila et al.   FERTILITY AND STERILITY

Regulation of mitochondrial polarity in mouse and human oocytes: the influence of cumulus derived nitric oxide

(2008) J. Van Blerkom et al.   MOLECULAR HUMAN REPRODUCTION

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

Prevalence of mitochondrial DNA disease in adults

(2007) Andrew M. Schaefer et al.   ANNALS OF NEUROLOGY

One-Cell Zygote Transfer from Diabetic to Nondiabetic Mouse Results in Congenital Malformations and Growth Retardation in Offspring

(2007) Amanda Wyman et al.   ENDOCRINOLOGY