AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner

SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity

(2020) Da Hyun Lee et al.   Autophagy

Crosstalk between autophagy and metabolic regulation of cancer stem cells

(2020) Mouradi El Hout et al.   Molecular Cancer

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

(2020) Eva Schrezenmeier et al.   Nature Reviews Rheumatology

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

(2020) Li Liu et al.   Cancers

Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells

(2020) Chen Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Crosstalks between inflammasome and autophagy in cancer

(2020) Chaeuk Chung et al.   Journal of Hematology & Oncology

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Mechanistic insight into the regulation of SQSTM1/p62

(2019) Yi Zhang et al.   Autophagy

Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy

(2019) Yong-guo Zhang et al.   Autophagy

FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy

(2019) Marc P. M. Soutar et al.   Autophagy

Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations

(2019) Nidhi Jatana et al.   Autophagy

TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status

(2019) Chen Liang et al.   Autophagy

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

(2019) Chenming Zeng et al.   Frontiers in Physiology

Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells

(2019) Jessica R. Murray et al.   CHEMICAL RESEARCH IN TOXICOLOGY

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

(2019) Yulin Shi et al.   Nature Communications

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer

(2018) Hong ZHU et al.   Theranostics

Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

(2018) Jen-Yang Tang et al.   SEMINARS IN CANCER BIOLOGY

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

(2018) Panagiotis Karras et al.   CANCER CELL

Autophagy, Cancer Stem Cells & Drug Resistance

(2018) Alexandra G. Smith et al.   JOURNAL OF PATHOLOGY

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

(2016) Haishan Huang et al.   Autophagy

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells

(2016) Ryuji Matsumoto et al.   Scientific Reports

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

(2015) Bettina Wurzer et al.   eLife

Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells

(2014) Toshiyuki Matsunaga et al.   ANTI-CANCER DRUGS

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

(2012) Daisuke Inoue et al.   CANCER SCIENCE

Pathophysiological roles of aldo–keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers

(2012) Toshiyuki Matsunaga et al.   CHEMICO-BIOLOGICAL INTERACTIONS

p62: a versatile multitasker takes on cancer

(2012) Jorge Moscat et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors

(2010) Ossama El-Kabbani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells

(2009) Chia-Wen Chien et al.   CARCINOGENESIS

Structure-Guided Design, Synthesis, and Evaluation of Salicylic Acid-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human 20α-Hydroxysteroid Dehydrogenase (AKR1C1)

(2009) Ossama El-Kabbani et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome

(2008) P. Faure et al.   EUROPEAN RESPIRATORY JOURNAL

Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid†

(2008) Urmi Dhagat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: Role in the cell cycle and apoptosis

(2007) Elisabet Selga et al.   BIOCHEMICAL PHARMACOLOGY

Proteomic Analysis for the Assessment of Different Lots of Fetal Bovine Serum as a Raw Material for Cell Culture. Part IV. Application of Proteomics to the Manufacture of Biological Drugs

(2006) Xiaoyang Zheng et al.   BIOTECHNOLOGY PROGRESS