Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors

(2018) Xuehua Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells

(2017) Yoshihiko Nakatani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells

(2016) Tian-yi Zhou et al.   Scientific Reports

In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis

(2015) Yining Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines

(2015) Maša Sinreih et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

(2015) Ji-Yeon Yu et al.   MOLECULES

Breast Cancer After Use of Estrogen Plus Progestin and Estrogen Alone

(2015) Rowan T. Chlebowski et al.   JAMA Oncology

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

Progesterone Receptor-A and -B Have Opposite Effects on Proinflammatory Gene Expression in Human Myometrial Cells: Implications for Progesterone Actions in Human Pregnancy and Parturition

(2012) Huiqing Tan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library

(2012) Petra Brožič et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

(2012) Jack U. Flanagan et al.   PLoS One

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

(2011) N. Hevir et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors

(2010) Ossama El-Kabbani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties

(2010) Ya-Xuan Sun et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure-Guided Design, Synthesis, and Evaluation of Salicylic Acid-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human 20α-Hydroxysteroid Dehydrogenase (AKR1C1)

(2009) Ossama El-Kabbani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1

(2008) P. Brožič et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid†

(2008) Urmi Dhagat et al.   JOURNAL OF MEDICINAL CHEMISTRY