Article
Pharmacology & Pharmacy
Shengli Wan, Qingze Fan, Yuesong Wu, Jingqing Zhang, Gan Qiao, Nan Jiang, Jie Yang, Yuanzhi Liu, Jingyan Li, Sawitree Chiampanichayakul, Singkome Tima, Fei Tong, Songyot Anuchapreeda, Jianming Wu
Summary: This study constructed a CUR-loaded platelet membrane bioinspired chitosan-modified liposome (PCLP-CUR) to improve CUR release. The developed delivery system showed long retention time, improved bioavailability, strong tumor targeting capacity, and effective cellular uptake. The incorporation of chitosan enabled PCLP-CUR to release cargoes quickly under mild acidic tumor conditions, leading to more complete drug release and favoring subsequent treatment. Both in vitro and in vivo investigations demonstrated that PCLP-CUR significantly enhanced the anticancer efficacy of CUR with minimal side effects, making it a promising strategy for tumor-targeting therapy and phytochemical delivery.
Article
Nanoscience & Nanotechnology
Jingmei Li, Jin Zhang, Yan Gao, Sibei Lei, Jieping Wu, Xiaohua Chen, Kaiyu Wang, Xingmei Duan, Ke Men
Summary: In this study, a cancer cell membrane-based drug delivery system, cMDS, was developed for efficient siRNA delivery. It also demonstrated strong cancer-specific immune response.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Polymer Science
Rui Li, Qing-Ling Zhou, Min-Rui Tai, Kathryn Ashton-Mourney, Mathew I. I. Harty, Aaqil Rifai, Clare L. L. Parish, David R. R. Nisbet, Sai-Yi Zhong, Richard J. J. Williams
Summary: Bioinspired self-assembly is a bottom-up strategy that can create nanostructured biogels with biological sophistication, capable of mimicking natural tissue. These self-assembling peptides (SAPs) form supramolecular nanostructures that intertwine to create hydrogel materials, which can serve as versatile frameworks for cell and tissue engineering scaffolds. SAPs are programmable and can be designed to possess innate biocompatibility, biodegradability, synthetic feasibility, biological functionality, and responsiveness to external stimuli. They can be used independently or in combination with other molecules to recreate complex biological functions in a simplified framework.
Article
Chemistry, Multidisciplinary
Lei Xing, Chen-Xi Yang, Di Zhao, Li-Jun Shen, Tian-Jiao Zhou, Yu-Yang Bi, Zhang-Jian Huang, Qiong Wei, Ling Li, Fei Li, Hu-Lin Jiang
Summary: Tolfplatin is a carrier-free self-delivered nanopmdrug that can inhibit tumor proliferation and metastasis by reducing PGE2 secretion and inducing apoptotic cell death.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Jing Liu, Si Si Liew, Jun Wang, Kanyi Pu
Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Fangfang Deng, Chenxi Wang, Chengjie Xiang, Ruzhu Wang
Summary: The study developed a promising adsorbent based on natural materials, showing high performance and low cost in atmospheric water harvesting technology. The adsorbent efficiently adsorbs and desorbs water, and has the potential to harvest water resources at a low cost.
Article
Materials Science, Multidisciplinary
Minjing Li, Tongzhen Yang, Qing Yang, Zheng Fang, Hao Bian, Chengjun Zhang, Xun Hou, Feng Chen
Summary: In this study, a multi-functional curved artificial compound eye (MF-ACE) was fabricated using a combination of femtosecond laser wet etching, soft lithography, and PDMS swelling methods. The MF-ACE exhibited excellent anti-fogging, anti-fouling, and self-cleaning abilities, as well as high optical performance and uniformity. It has potential applications in various fields under harsh environmental conditions.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Fengjun Sun, Yu Wang, Qianmei Wang, Xiaowen Wang, Pu Yao, Wei Feng, Qian Yuan, Xiaowei Qi, Sheng Chen, Wendan Pu, Rong Huang, Qing Dai, Jun Lv, Qian Wang, Wenhao Shen, Peiyuan Xia, Dinglin Zhang
Summary: This study synthesized a photocleavable nanoprodrug that can release an antitumor drug through UV light. The nanoprodrug was efficiently internalized by tumor cells, leading to a significant inhibition of tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
D. N. Yadav, S. A. Sankaranarayanan, A. M. Thanekar, A. K. Rengan
Summary: We report the development of a unique bioinspired phage nanosome that can tune the NIR absorbance of gold nanoparticles on its surface. The presence of the phage significantly enhances the optical properties of the encapsulated dyes, making them excellent imaging agents. In vitro and in vivo studies demonstrate the nanosomes' enhanced photothermal transduction efficacy, biocompatibility, and potential as an anti-microbial and anti-cancer theranostic agent.
MATERIALS TODAY NANO
(2023)
Article
Pharmacology & Pharmacy
Rasoul Shahbazi, Davoud Jafari-Gharabaghlou, Zohreh Mirjafary, Hamid Saeidian, Nosratollah Zarghami
Summary: In this study, PEGylated niosomal nanoparticles loaded with ART-MET were synthesized and characterized. The results showed that these nanoparticles can inhibit the growth of A549 lung cancer cells and induce apoptotic gene expression.
PHARMACOLOGICAL REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Xianglian Li, Hui Liu, Ailing Yu, Dan Lin, Zhishu Bao, Yuqin Wang, Xingyi Li
Summary: The newly designed NapFFKKFKLKL/Dexp supramolecular hydrogel displayed controlled drug release behavior, good intraocular biocompatibility, and potent anti-inflammatory capacity, making it a promising drug carrier system for treating posterior disorders such as uveitis.
CHINESE CHEMICAL LETTERS
(2021)
Review
Chemistry, Multidisciplinary
Arun Kumar Singh, Rajendra Awasthi, Rishabha Malviya
Summary: Chemotherapy is the most effective technique for treating cancer, but it comes with high risk of side effects. To avoid unintended consequences and negative effects, many nanomedicines have been developed. Microrobots are gaining attention as a solution to achieve targeted drug delivery and overcome challenges. Different types of microrobots, such as moving bacteria, microengines powered by bubbles, and hybrid spermbots, offer complex features for precise targeting of various cancers.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Xiaoqiu Xu, Tong Li, Ke Jin
Summary: Nanomedicines offer alternative strategies for tumor-targeted therapy due to their nanoscale size and tunable surface features. Biomimetic nanomedicines show promising potential in maximizing anti-tumor efficacy with minimal adverse effects due to their good biocompatibility and high accumulation abilities.
Article
Engineering, Environmental
Xiao Fu, Xiaoxuan Zhang, Danqing Huang, Liang Mao, Yudong Qiu, Yuanjin Zhao
Summary: Inspired by the structures of octopus tentacles, researchers have developed a novel adhesive microneedle patch with gemcitabine encapsulation for the treatment of pancreatic cancer. The patch, made of gelatin methacryloyl, demonstrates good biocompatibility, flexibility, and drug loading efficiency. It can adhere to the irregular surfaces of tumors and efficiently release gemcitabine to penetrate tumor tissues, showing promising anti-tumor efficacy in vitro and in a mouse model.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yi-Jing Li, Lingze Zhang, Pei-Pei Yang, Kuo Zhang, Xue-Feng Gong, Da-Yong Hou, Hui Cao, Xiao-Chun Wu, Ruiwu Liu, Kit S. Lam, Lei Wang
Summary: In this study, anti-adhesion peptides (AAPs) were screened using a combinatorial peptide library method, and these peptides were then coated on gold nanorods to enhance their circulation half-life and alter their biodistribution profile in mice. The bioinspired screening strategy and resulting peptides show great potential for enhancing the delivery efficiency and targeting ability of nanomaterials.
Article
Chemistry, Multidisciplinary
Xuehao Zeng, Huigang Tong, Shi Chen, Jian Lu, Changlai Wang, Jinwei Tu, Pengcheng Wang, Qianwang Chen
Summary: Transition metal sulfides have always been considered promising anode materials for potassium-ion batteries due to their high theoretical capacity. However, their low conductivity, poor ionic diffusivity, sluggish reaction kinetics, and severe volume expansion have hindered their practical application. In this study, a carbon-coated CoSx@CNT material was developed, which effectively addressed these issues and demonstrated excellent potassium storage performance.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Zhanpeng Huang, Weiwei Zhang, Hong Zhang, Lin Fu, Bin Song, Wenli Zhang, Qianwang Chen, Ke Lu
Summary: Interfacial engineering using a metal-organic framework cation reservoir as a zincophile interphase offers a solution to manipulate zinc-ion flux, suppress side reactions, and improve the performance of zinc metal anodes.
JOURNAL OF POWER SOURCES
(2022)
Article
Chemistry, Multidisciplinary
Xiangfu Meng, Ke Zhou, Yong Qian, Hongji Liu, Xingyu Wang, Yefeng Lin, Xinyi Shi, Yu Tian, Yijun Lu, Qianwang Chen, Junchao Qian, Hui Wang
Summary: The designed HCONC nanzymes with dual-shell structures exhibit excellent antitumor ability by inducing Fenton-like reaction to produce highly toxic hydroxyl radicals, reducing systemic toxicity.
Article
Chemistry, Multidisciplinary
Jinwei Tu, Huigang Tong, Xuehao Zeng, Shi Chen, Changlai Wang, Wei Zheng, Hui Wang, Qianwang Chen
Summary: In this study, a sulfonic acid modified porous N-doped carbon (SA-NC) was prepared as an anode material for potassium-ion batteries (PIBs). The SA-NC material provides abundant migration channels and active potassium storage sites, promoting reversible surface adsorption and desorption of potassium ions and improving the storage performance and initial coulombic efficiency. The material exhibits outstanding performance in terms of charging capacity, cyclic stability, and capacity retention.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hong Zhang, Bin Song, Weiwei Zhang, Bowen An, Lin Fu, Songtao Lu, Yingwen Cheng, Qianwang Chen, Ke Lu
Summary: In this study, core-shell structured composite matrixes were used to achieve nearly fully reversible cycling of sulfur cathodes for Na-S batteries. The bidirectional tandem electrocatalysis enabled successive reversible conversion of both long- and short-chain polysulfides, while Fe2O3 and redox-active Fe(CN)(6)(4-)-doped polypyrrole shell facilitated specific conversions. The electrochemically reactive Na2S could be readily charged back to sulfur, and stable cycling of a Na-S pouch cell with high reversible capacity was demonstrated.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jie Yang, Ge Yao, Zhiqiang Li, Yuhang Zhang, Lingzhi Wei, Helin Niu, Qianwang Chen, Fangcai Zheng
Summary: This study addresses the challenges of structural stability and electronic conductivity in aqueous zinc-ion batteries (AZIBs) by generating ultrathin δ-MnO2 with enlarged interlayer spacing on a flexible carbon membrane. The enlarged interlayer spacing allows for reversible intercalation/deintercalation of H+/Zn2+ ions, resulting in improved charge storage and cycle performance.
Article
Chemistry, Multidisciplinary
Hao Huang, Shi Chen, Peng Jiang, Yang Yang, Changlai Wang, Wei Zheng, Zhiyu Cheng, Minxue Huang, Lin Hu, Qianwang Chen
Summary: Theoretical calculations demonstrate that lithium embedded in N, O-doped graphene is an effective electrocatalytic active center for CO2 reduction and oxygen reduction reactions. This is due to the s-p orbital hybridization between the empty 2p orbital of lithium and the orbitals of coordinated atoms. Experimental results show that a carbon-based catalyst with well-anchored lithium atoms coordinated to N, O substituents exhibits exceptional performance in CO2 reduction and oxygen reduction reactions in acidic media.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ge Yao, Zhiqiang Li, Yuhang Zhang, Yue Xiao, Lingzhi Wei, Helin Niu, Qianwang Chen, Yang Yang, Fangcai Zheng
Summary: In this study, a flexible carbon film implanted with single-atomic Zn-N-2 moiety was constructed as an efficient sulfur host material to improve the redox kinetics and electrical conductivity of sulfur cathode in room-temperature sodium-sulfur batteries.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dongdong Wang, Lei Zhang, Changlai Wang, Zhiyu Cheng, Wei Zheng, Pengping Xu, Qianwang Chen, Yanli Zhao
Summary: Researchers develop a facile missing-linker-confined coordination strategy to fabricate two self-assembled nanozymes: conventional nanozyme (NE) and single-atomic nanozyme (SAE). They consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal-organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, exhibiting more efficient reactive oxygen species generation and higher tumor inhibition rate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jinwei Tu, Huigang Tong, Peichen Wang, Dongdong Wang, Yang Yang, Xiangfu Meng, Lin Hu, Hui Wang, Qianwang Chen
Summary: Due to the deficiency and uneven distribution of lithium resources, potassium-ion batteries have attracted more attention as viable alternatives to lithium-ion batteries. This study shows that the unique anti-spinel structure of magnetite can serve as K+ storage sites, and carbon-coated Fe3O4@C nanoparticles exhibit high reversible capacity and hyper stable cycling performance in potassium-ion batteries.
Article
Multidisciplinary Sciences
Dongdong Wang, Jiawei Liu, Changlai Wang, Weiyun Zhang, Guangbao Yang, Yun Chen, Xiaodong Zhang, Yinglong Wu, Long Gu, Hongzhong Chen, Wei Yuan, Xiaokai Chen, Guofeng Liu, Bin Gao, Qianwang Chen, Yanli Zhao
Summary: Cancer immunotherapy is revolutionizing oncology and the combination of nanotechnology and immunotherapy provides an opportunity to enhance antitumor immune response. This study presents a mitochondria-targeting nanoplatform, MiBaMc, which consists of Prussian blue nanoparticles derived from bacteria and shows enhanced tumor inhibition in mouse models. The findings demonstrate the potential of targeted nanoparticles in boosting antitumor immunity.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Peichen Wang, Yafei Qu, Xiangfu Meng, Jinwei Tu, Wei Zheng, Lin Hu, Qianwang Chen
Summary: As an external field, a magnetic field can influence the electrocatalytic activity of catalysts through various effects, such as electron spin polarization. In this study, we investigate the sensitive response behavior of Cu2O nanocubes to an in situ magnetic field. The results show that a strong magnetic field increases the transferred electron quantity and current density, while decreasing the onset potential. Additionally, the magnetic field alters the product selectivity, with an increase in the Faraday efficiency of C-1.
Article
Chemistry, Multidisciplinary
Dong Wang, Shuo Shi, Yanyun Mao, Leqi Lei, Shaohai Fu, Jinlian Hu
Summary: A novel dual-network design strategy is proposed to prepare a high-performance cellulosic composite bioplastic metafilm with exceptional mechanical toughness, flame retardance, and solvent resistance. The metafilm exhibits a higher maximum usage temperature, lower thermal expansion coefficient, good biocompatibility, and natural biodegradation, making it a competitive substitute for plastics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Yafei Qu, Wei Zheng, Peichen Wang, Hao Huang, Minxue Huang, Lin Hu, Hui Wang, Qianwang Chen
Summary: Electrochemical carbon dioxide reduction reaction (CO2RR) is an effective method to capture and convert CO2 into valuable chemicals and fuels, reducing CO2 emissions. Copper-based catalysts have shown excellent performance in converting CO2 into multi-carbon compounds and hydrocarbons. However, their selectivity towards coupling products is poor.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Xiaojuan Zhang, Zhiqiang Li, Xinpeng Sun, Lingzhi Wei, Helin Niu, Shan Chen, Qianwang Chen, Changlai Wang, Fangcai Zheng
Summary: This study introduces ruthenium to regulate the surface electronic structure of nickel and optimize its electrocatalytic performance in hydrogen oxidation reactions. By constructing an interfacial-oxygen configuration, the adsorption energy for surface hydroxyl species is optimized. The experimental results show that electron transfer from nickel to ruthenium weakens the hydrogen binding energy and hydroxyl binding energy, leading to enhanced performance in hydrogen oxidation reactions. Additionally, the catalyst exhibits good tolerance towards CO, making it a promising electrocatalyst for hydrogen fuel cells.
ACS MATERIALS LETTERS
(2022)
