Journal
SMALL
Volume 18, Issue 15, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202107422
Keywords
cascade reactions; chemodynamic therapy; cuprous oxides; dual-shell structures; hollow cavity
Categories
Funding
- National Key R&D Program of China [2021YFA1600202]
- National Natural Science Foundation of China [U2032162, U1932158, 81871085]
- Hefei Municipal Natural Science Foundation [2021009]
- Natural Science Foundation of Shandong Province [ZR2019LZL018]
- High Magnetic Field Laboratory of Anhui Province [AHHM-FX-2021-04]
- Project of Postdoctoral Science Foundation of China [2019M652403]
- Project of Postdoctoral Innovation of Shandong Province [202002048]
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The designed HCONC nanzymes with dual-shell structures exhibit excellent antitumor ability by inducing Fenton-like reaction to produce highly toxic hydroxyl radicals, reducing systemic toxicity.
Cuprous-based nanozymes have demonstrated great potential for cascade chemodynamic therapy (CDT) due to their higher catalytic efficiency and simple reaction conditions. Here, hollow cuprous oxide@nitrogen-doped carbon (HCONC) dual-shell structures are designed as nanozymes for CDT oncotherapy. This HCONC with a size distribution of 130 nm is synthesized by a one-step hydrothermal method using cupric nitrate and dimethyl formamide as precursors. The thin-layer carbon (1.88 nm) of HCONC enhances the water-stability and reduces the systemic toxicity of cuprous oxide nanocrystals. The dissolved Cu+ of HCONC in acid solution induces a Fenton-like reaction and exhibits a fast reaction rate for catalyzing H2O2 into highly toxic hydroxyl radicals (center dot OH). Meanwhile, the formed Cu+ consumes oversaturated glutathione (GSH) to avoid its destruction of ROS at the intracellular level. In general, both cellular and animal experiments show that HCONC demonstrates excellent antitumor ability without causing significant systemic toxicity, which may present tremendous potential for clinical cancer therapy.
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