Use of Physiologically Based Pharmacokinetic Modeling for Predicting Drug–Food Interactions: Recommendations for Improving Predictive Performance of Low Confidence Food Effect Models

Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach

(2021) Xavier J. H. Pepin et al.   AAPS Journal

Prediction of negative food effect induced by bile micelle binding on oral absorption of hydrophilic cationic drugs

(2020) Yoshiyuki Akiyama et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of the P‐Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4‐Way Crossover Drug‐Drug Interaction Study in Healthy Subjects

(2019) Bayew Tsega Abebe et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Mass Transport Analysis of Bicarbonate Buffer: Effect of the CO2–H2CO3 Hydration–Dehydration Kinetics in the Fluid Boundary Layer and the Apparent Effective pKa Controlling Dissolution of Acids and Bases

(2019) Jozef Al-Gousous et al.   MOLECULAR PHARMACEUTICS

Improved prediction of in vivo supersaturation and precipitation of poorly soluble weakly basic drugs using a biorelevant bicarbonate buffer in a GI transfer model

(2019) Christian Jede et al.   MOLECULAR PHARMACEUTICS

Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: The hidden role of bicarbonate buffer

(2019) Daniela Amaral Silva et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

(2018) Patrick J. O'Dwyer et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects

(2018) Michael Grimm et al.   MOLECULAR PHARMACEUTICS

Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions

(2017) Michael Grimm et al.   MOLECULAR PHARMACEUTICS

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

(2017) James Mann et al.   MOLECULAR PHARMACEUTICS

Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers

(2016) Mirko Koziolek et al.   ADVANCED DRUG DELIVERY REVIEWS

Trospium chloride is absorbed from two intestinal “absorption windows” with different permeability in healthy subjects

(2016) Tobias Tadken et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Advances in the design of fasted state simulating intestinal fluids: FaSSIF-V3

(2015) Alexander Fuchs et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies

(2015) M. Koziolek et al.   JOURNAL OF CONTROLLED RELEASE

In Vivo Predictive Dissolution: Comparing the Effect of Bicarbonate and Phosphate Buffer on the Dissolution of Weak Acids and Weak Bases

(2015) Brian J. Krieg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intragastric Volume Changes after Intake of a High-Caloric, High-Fat Standard Breakfast in Healthy Human Subjects Investigated by MRI

(2014) Mirko Koziolek et al.   MOLECULAR PHARMACEUTICS

Dried blood spot testing: a novel approach for the therapeutic drug monitoring of ziprasidone-treated patients

(2014) Laura Mercolini et al.   Bioanalysis

Trospium Chloride: Unusual Example of Polymorphism Based on Structure Disorder

(2013) Eliška Skořepová et al.   CRYSTAL GROWTH & DESIGN

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights

(2013) L Marciani et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds

(2013) Grzegorz Garbacz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ion Pairing with Bile Salts Modulates Intestinal Permeability and Contributes to Food–Drug Interaction of BCS Class III Compound Trospium Chloride

(2013) Christian A. Heinen et al.   MOLECULAR PHARMACEUTICS

Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer

(2013) Yanli Deng et al.   XENOBIOTICA

Pharmacokinetic and Bioequivalence Studies of Trospium chloride after a Single-dose Administration in Healthy Chinese Volunteers

(2012) R. Zhang et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity

(2012) Asma Radwan et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation

(2011) Jonathan M. Miller et al.   MOLECULAR PHARMACEUTICS

Phosphatidylcholine as a constituent in the colonic mucosal barrier—Physiological and clinical relevance

(2010) Robert Ehehalt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Phase I Study of the Pharmacokinetic and Safety Profiles of Oral Pazopanib With a High-Fat or Low-Fat Meal in Patients With Advanced Solid Tumors

(2010) E I Heath et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Gastric emptying of multi-particulate dosage forms

(2010) J. Michael Newton   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Determination of the quaternary ammonium compound trospium in human plasma by LC–MS/MS: Application to a pharmacokinetic study

(2010) Kishore Kumar Hotha et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Modeling the Fluid Dynamics in a Human Stomach to Gain Insight of Food Digestion

(2010) M.J. Ferrua et al.   JOURNAL OF FOOD SCIENCE

Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies

(2010) Karen Kleberg et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Simulating Fasted Human Intestinal Fluids: Understanding the Roles of Lecithin and Bile Acids

(2010) Erik Söderlind et al.   MOLECULAR PHARMACEUTICS

Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug

(2010) Sara Carlert et al.   PHARMACEUTICAL RESEARCH

Phase I Trial of Pazopanib in Patients with Advanced Cancer

(2009) H. I. Hurwitz et al.   CLINICAL CANCER RESEARCH

The Impact of Calories and Fat Content of Meals on Oral Ziprasidone Absorption

(2009) Kuan Gandelman et al.   JOURNAL OF CLINICAL PSYCHIATRY

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

Bioavailability of amoxicillin and clavulanic acid from extended release tablets depends on intragastric tablet deposition and gastric emptying

(2008) W. Weitschies et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Estimation of effective intestinal membrane permeability considering bile micelle solubilisation

(2008) Kiyohiko Sugano   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH