SIRT1 attenuates renal fibrosis by repressing HIF-2α

Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

(2019) Dong Ryeol Ryu et al.   AGING CELL

Pterostilbene prevents hepatocyte EMT in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signaling

(2019) Lin Song et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress

(2017) Yunzhuo Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Signalling pathways involved in hypoxia-induced renal fibrosis

(2017) Minna Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction

(2017) Li Nie et al.   EBioMedicine

HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice

(2016) Bijaya K. Nayak et al.   DIABETES

Physiology of the Renal Interstitium

(2015) M. Zeisberg et al.   Clinical Journal of the American Society of Nephrology

Inhibition of STAT3 acetylation is associated with attenuated renal fibrosis in the obstructed kidney

(2014) Jun Ni et al.   ACTA PHARMACOLOGICA SINICA

Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

(2014) Pawel Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of Transcription Factor Acetylation in Diabetic Kidney Disease

(2014) R. Liu et al.   DIABETES

Chronic kidney disease and the ageing population

(2014) Marcello Tonelli et al.   LANCET

PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α

(2014) Cheng Sun et al.   Cell Reports

3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

(2013) Guoguo Shang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF-β/Smad3 Pathway

(2013) Xin-Zhong Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence

(2013) R. Vasko et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury

(2013) Hong Fan et al.   KIDNEY INTERNATIONAL

Generation of a Tenascin-C-CreER2 Knockin Mouse Line for Conditional DNA Recombination in Renal Medullary Interstitial Cells

(2013) Wenjuan He et al.   PLoS One

Resveratrol Attenuates Diabetic Nephropathy via Modulating Angiogenesis

(2013) Donghai Wen et al.   PLoS One

Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury

(2013) Jason A. Funk et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Hypoxia-inducible factor signaling in the development of tissue fibrosis

(2011) Debra F. Higgins et al.   CELL CYCLE

Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts

(2011) Brad C. Astor et al.   KIDNEY INTERNATIONAL

Alteration of Forkhead Box O (Foxo4) Acetylation Mediates Apoptosis of Podocytes in Diabetes Mellitus

(2011) Peter Y. Chuang et al.   PLoS One

Sirt1 activation protects the mouse renal medulla from oxidative injury

(2010) Wenjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirtuins and Their Relevance to the Kidney

(2010) C.-M. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

(2009) Y. R. Song et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

(2008) Leon G. Fine et al.   KIDNEY INTERNATIONAL

Hypoxia and Hypoxia-Inducible Factor in Renal Disease

(2008) Masaomi Nangaku et al.   NEPHRON EXPERIMENTAL NEPHROLOGY