The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

(2019) Robbert Q. Kim et al.   Nature Communications

USP7 Regulates Cytokinesis through FBXO38 and KIF20B

(2019) Anna Georges et al.   Scientific Reports

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

(2019) Maria Azkanaz et al.   eLife

USP7–TRIM27 axis negatively modulates antiviral type I IFN signaling

(2018) Juan Cai et al.   FASEB JOURNAL

Improvement of ubiquitylation site detection by Orbitrap mass spectrometry

(2018) Lennart van der Wal et al.   Journal of Proteomics

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

(2018) Pablo Palazón‐Riquelme et al.   EMBO REPORTS

Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis

(2018) Dongxue Su et al.   JOURNAL OF CLINICAL INVESTIGATION

UbE2E1/UBCH6 Is a Criticalin VivoE2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119

(2017) Keith Wheaton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of regulation and diversification of deubiquitylating enzyme function

(2017) Pawel Leznicki et al.   JOURNAL OF CELL SCIENCE

Regulation of USP7: A High Incidence of E3 Complexes

(2017) Robbert Q. Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

USP7 small-molecule inhibitors interfere with ubiquitin binding

(2017) Lorna Kategaya et al.   NATURE

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

(2017) Andrew P. Turnbull et al.   NATURE

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

(2017) Gerald Gavory et al.   Nature Chemical Biology

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

(2017) Giovanna Carrà et al.   Oncotarget

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Myelodysplastic Syndromes and Acute Myeloid Leukemia in the Elderly

(2016) Heidi D. Klepin   CLINICS IN GERIATRIC MEDICINE

Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response

(2016) Xiaoliang Liu et al.   FEBS LETTERS

Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis

(2016) Jaclyn Andricovich et al.   JOURNAL OF CLINICAL INVESTIGATION

Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model

(2016) P Sontakke et al.   LEUKEMIA

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1

(2016) Sarah J. Wong et al.   STRUCTURE

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

(2016) Vincent van den Boom et al.   Cell Reports

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2

(2015) T. Ueda et al.   BLOOD

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms

(2015) Lluis Morey et al.   Cell Stem Cell

USP7 Cooperates with SCML2 To Regulate the Activity of PRC1

(2015) Emilio Lecona et al.   MOLECULAR AND CELLULAR BIOLOGY

USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder

(2015) Yi-Heng Hao et al.   MOLECULAR CELL

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation

(2015) Jingdong Cheng et al.   Nature Communications

TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution

(2015) H-A Hou et al.   Blood Cancer Journal

STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation

(2015) Mao Ye et al.   Oncotarget

Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis

(2015) Mengcheng Luo et al.   PLoS Genetics

ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases

(2014) Li Shen et al.   BMC GENOMICS

NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells

(2014) F. Kottakis et al.   CANCER RESEARCH

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells

(2013) V. van den Boom et al.   BLOOD

Ubiquitination-Deubiquitination by the TRIM27-USP7 Complex Regulates Tumor Necrosis Factor Alpha-Induced Apoptosis

(2013) M. M.-U. Zaman et al.   MOLECULAR AND CELLULAR BIOLOGY

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation

(2013) Xudong Wu et al.   MOLECULAR CELL

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

(2013) Karin Klauke et al.   NATURE CELL BIOLOGY

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes

(2013) Jin He et al.   NATURE CELL BIOLOGY

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

(2013) Y-H Fan et al.   Cell Death & Disease

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation

(2012) Ana O'Loghlen et al.   Cell Stem Cell

Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells

(2012) Lluis Morey et al.   Cell Stem Cell

MLL–AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny

(2012) S J Horton et al.   LEUKEMIA

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

(2011) J. He et al.   BLOOD

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

(2011) F. G. Rucker et al.   BLOOD

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

Therapeutic Advances in Acute Myeloid Leukemia

(2011) Alan Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells

(2011) J Yuan et al.   LEUKEMIA

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

(2011) Alex C. Faesen et al.   MOLECULAR CELL

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

Regulation of the Polycomb protein RING1B ubiquitination by USP7

(2010) Prim de Bie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells

(2010) A. Rizo et al.   BLOOD

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

(2010) Goedele N Maertens et al.   EMBO JOURNAL

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis

(2009) A. Rizo et al.   BLOOD

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

Inactivation of HAUSP in vivo modulates p53 function

(2009) N Kon et al.   ONCOGENE

EBNA1-Mediated Recruitment of a Histone H2B Deubiquitylating Complex to the Epstein-Barr Virus Latent Origin of DNA Replication

(2009) Feroz Sarkari et al.   PLoS Pathogens

TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype and is associated with very poor prognosis

(2008) D Bowen et al.   LEUKEMIA

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

(2008) Jin He et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY