Artificially Induced Pluripotent Stem Cell-Derived Whole-Brain Organoid for Modelling the Pathophysiology of Metachromatic Leukodystrophy and Drug Repurposing
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Title
Artificially Induced Pluripotent Stem Cell-Derived Whole-Brain Organoid for Modelling the Pathophysiology of Metachromatic Leukodystrophy and Drug Repurposing
Authors
Keywords
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Journal
Biomedicines
Volume 9, Issue 4, Pages 440
Publisher
MDPI AG
Online
2021-04-21
DOI
10.3390/biomedicines9040440
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Note: Only part of the references are listed.- Genetic testing of leukodystrophies unraveling extensive heterogeneity in a large cohort and report of five common diseases and 38 novel variants
- (2021) Nejat Mahdieh et al. Scientific Reports
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- (2021) Sally Esmail et al. Frontiers in Aging Neuroscience
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- (2020) Aparna Bhaduri et al. NATURE
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- (2020) Augustin Chen et al. Frontiers in Cellular Neuroscience
- Modeling and Targeting Alzheimer’s Disease With Organoids
- (2020) Angelos Papaspyropoulos et al. Frontiers in Pharmacology
- Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles
- (2020) Sarah Logan et al. Cells
- Human organoids: model systems for human biology and medicine
- (2020) Jihoon Kim et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Comprehensive clinical, biochemical, radiological and genetic analysis of 28 Turkish cases with suspected metachromatic leukodystrophy and their relatives
- (2020) Faruk Pekgül et al. Molecular Genetics and Metabolism Reports
- Spectrum of ARSA variations in Asian Indian patients with Arylsulfatase A deficient metachromatic leukodystrophy
- (2019) Dhanya Lakshmi Narayanan et al. JOURNAL OF HUMAN GENETICS
- Brain organoids: a next step for humanized Alzheimer’s disease models?
- (2019) Yannis Gerakis et al. MOLECULAR PSYCHIATRY
- DeepNEU: cellular reprogramming comes of age – a machine learning platform with application to rare diseases research
- (2019) Wayne R. Danter Orphanet Journal of Rare Diseases
- Lysosomal Leukodystrophies Lysosomal Storage Diseases Associated With White Matter Abnormalities
- (2019) Gustavo H.B. Maegawa JOURNAL OF CHILD NEUROLOGY
- Brain organoids: advances, applications and challenges
- (2019) Xuyu Qian et al. DEVELOPMENT
- Insights into the natural history of metachromatic leukodystrophy from interviews with caregivers
- (2019) Magdalena Harrington et al. Orphanet Journal of Rare Diseases
- Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins
- (2019) Hyosung Kim et al. Stem Cell Reports
- Disease modelling in human organoids
- (2019) Madeline A. Lancaster et al. Disease Models & Mechanisms
- Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
- (2019) Silvia Velasco et al. NATURE
- Peripheral neuropathy in metachromatic leukodystrophy: current status and future perspective
- (2019) Shanice Beerepoot et al. Orphanet Journal of Rare Diseases
- Neural Lineage Differentiation From Pluripotent Stem Cells to Mimic Human Brain Tissues
- (2019) Yean Ju Hong et al. Frontiers in Bioengineering and Biotechnology
- Generation of human brain region–specific organoids using a miniaturized spinning bioreactor
- (2018) Xuyu Qian et al. Nature Protocols
- Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy
- (2018) Giacomo Frati et al. Cell Death & Disease
- Brain Cell Type Specific Gene Expression and Co-expression Network Architectures
- (2018) Andrew T. McKenzie et al. Scientific Reports
- Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way
- (2018) Ira Espuny-Camacho et al. Cell Reports
- Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
- (2018) Olivia Krefft et al. Jove-Journal of Visualized Experiments
- Applications of human brain organoids to clinical problems
- (2018) H. Isaac Chen et al. DEVELOPMENTAL DYNAMICS
- Gene therapy for metachromatic leukodystrophy
- (2016) Jonathan B. Rosenberg et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Distinctive Features of the Human Marginal Zone and Cajal–Retzius Cells: Comparison of Morphological and Immunocytochemical Features at Midgestation
- (2016) Lyubov A. Tkachenko et al. Frontiers in Neuroanatomy
- Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy
- (2016) Vasco Meneghini et al. Stem Cells Translational Medicine
- Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation
- (2015) Martina Zemke et al. BMC BIOLOGY
- Establishment and Dysfunction of the Blood-Brain Barrier
- (2015) Zhen Zhao et al. CELL
- Late infantile metachromatic leukodystrophy: Clinical manifestations of five Taiwanese patients and Genetic features in Asia
- (2015) Hsiang-Ru Liaw et al. Orphanet Journal of Rare Diseases
- Deterministic HOX Patterning in Human Pluripotent Stem Cell-Derived Neuroectoderm
- (2015) Ethan S. Lippmann et al. Stem Cell Reports
- Generation of cerebral organoids from human pluripotent stem cells
- (2014) Madeline A Lancaster et al. Nature Protocols
- Cerebral organoids model human brain development and microcephaly
- (2013) Nobutaka Hattori MOVEMENT DISORDERS
- Localizing Genes to Cerebellar Layers by Classifying ISH Images
- (2012) Lior Kirsch et al. PLoS Computational Biology
- Metachromatic Leukodystrophy: A Scoring System for Brain MR Imaging Observations
- (2009) F. Eichler et al. AMERICAN JOURNAL OF NEURORADIOLOGY
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