MYC2 Transcription Factors TwMYC2a and TwMYC2b Negatively Regulate Triptolide Biosynthesis in Tripterygium wilfordii Hairy Roots

The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila

(2021) Xiaolong Hao et al.   Horticulture Research

Isolation and Functional Characterization of the Promoters of Miltiradiene Synthase Genes, TwTPS27a and TwTPS27b, and Interaction Analysis with the Transcription Factor TwTGA1 from Tripterygium wilfordii

(2021) Yanbo Huo et al.   Plants-Basel

Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

(2020) Lichan Tu et al.   Nature Communications

Redox‐active cysteines in TGACG‐BINDING FACTOR 1 (TGA1) do not play a role in salicylic acid‐ or pathogen‐induced expression of TGA1‐regulated target genes in Arabidopsis thaliana

(2020) Jelena Budimir et al.   NEW PHYTOLOGIST

Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway

(2020) Yuan-Fei Shi et al.   Cell Death & Disease

Molecular Cloning and Functional Characterization of CpMYC2 and CpBHLH13 Transcription Factors from Wintersweet (Chimonanthus praecox L.)

(2020) Muhammad Zeshan Aslam et al.   Plants-Basel

SmMYC2b Enhances Tanshinone Accumulation in Salvia miltiorrhiza by Activating Pathway Genes and Promoting Lateral Root Development

(2020) Yangyun Zhou et al.   Frontiers in Plant Science

Clade I TGA bZIP transcription factors mediate BLADE-ON-PETIOLE-dependent regulation of development

(2019) Ying Wang et al.   PLANT PHYSIOLOGY

The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza

(2019) Yu Zhang et al.   PLANT MOLECULAR BIOLOGY

Jasmonate responsive transcription factor WsMYC2 regulates the biosynthesis of triterpenoid withanolides and phytosterol via key pathway genes in Withania somnifera (L.) Dunal

(2019) Arti Sharma et al.   PLANT MOLECULAR BIOLOGY

A myelocytomatosis transcription factor from Hevea brasiliensis positively regulates the expression of the small rubber particle protein gene

(2019) Dong Guo et al.   INDUSTRIAL CROPS AND PRODUCTS

A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii

(2019) Peng Li et al.   NATURAL PRODUCT RESEARCH

Analysis of the role of geranylgeranyl diphosphate synthase 8 from Tripterygium wilfordii in diterpenoids biosynthesis

(2019) Ping Su et al.   PLANT SCIENCE

Agrobacterium rhizogenes-mediated RNAi of Tripterygium wilfordii and application for functional study of terpenoid biosynthesis pathway genes

(2019) Bin Zhang et al.   INDUSTRIAL CROPS AND PRODUCTS

Glutaredoxin S25 and its interacting TGACG motif-binding factor TGA2 mediate brassinosteroid-induced chlorothalonil metabolism in tomato plants

(2019) Jiayin Hou et al.   ENVIRONMENTAL POLLUTION

The expression of TwDXS in the MEP pathway specifically affects the accumulation of triptolide

(2019) Yifeng Zhang et al.   PHYSIOLOGIA PLANTARUM

SmbHLH3 acts as a transcription repressor for both phenolic acids and tanshinone biosynthesis in Salvia miltiorrhiza hairy roots

(2019) Chenlu Zhang et al.   PHYTOCHEMISTRY

A class I TGA transcription factor from Tripterygium wilfordii Hook.f. modulates the biosynthesis of secondary metabolites in both native and heterologous hosts

(2019) Juan Han et al.   PLANT SCIENCE

Diterpenoids and lignans from the leaves of Tripterygium wilfordii

(2018) Fangyou Chen et al.   FITOTERAPIA

Jasmonate signalling in the regulation of rubber biosynthesis in laticifer cells of rubber tree, Hevea brasiliensis

(2018) Xiaomin Deng et al.   JOURNAL OF EXPERIMENTAL BOTANY

The ethylene response factor SmERF6 co-regulates the transcription of SmCPS1 and SmKSL1 and is involved in tanshinone biosynthesis in Salvia miltiorrhiza hairy roots

(2018) Zhenqing Bai et al.   PLANTA

TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis

(2018) Meng Zhang et al.   Frontiers in Plant Science

Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii

(2018) Jiadian Wang et al.   GENE

Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells

(2018) Heng Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Overexpression of SmbHLH10 enhances tanshinones biosynthesis in Salvia miltiorrhiza hairy roots

(2018) Bingcong Xing et al.   PLANT SCIENCE

The regulatory module MdPUB29-MdbHLH3 connects ethylene biosynthesis with fruit quality in apple

(2018) Da-Gang Hu et al.   NEW PHYTOLOGIST

TGACG-BINDING FACTOR 1 (TGA1) and TGA4 regulate salicylic acid and pipecolic acid biosynthesis by modulating the expression of SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1 ) and CALMODULIN-BINDING PROTEIN 60g (CBP60g )

(2017) Tongjun Sun et al.   NEW PHYTOLOGIST

Transcription Factor AsMYC2 Controls the Jasmonate-Responsive Expression of ASS1 Regulating Sesquiterpene Biosynthesis in Aquilaria sinensis (Lour.) Gilg

(2017) Yan-Hong Xu et al.   PLANT AND CELL PHYSIOLOGY

Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii

(2017) Ping Su et al.   PLANT JOURNAL

The terpene synthase gene family inTripterygium wilfordiiharbors a labdane-type diterpene synthase among the monoterpene synthase TPS-b subfamily

(2017) Nikolaj L. Hansen et al.   PLANT JOURNAL

Overexpression of SmMYC2 Increases the Production of Phenolic Acids in Salvia miltiorrhiza

(2017) Na Yang et al.   Frontiers in Plant Science

Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii

(2017) Qiqing Cheng et al.   Acta Pharmaceutica Sinica B

Role and functioning of bHLH transcription factors in jasmonate signalling

(2016) Jonas Goossens et al.   JOURNAL OF EXPERIMENTAL BOTANY

The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis inArtemisia annua

(2016) Qian Shen et al.   NEW PHYTOLOGIST

The molecular cloning and functional characterization of MdMYC2, a bHLH transcription factor in apple

(2016) Jian-Ping An et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

SmMYC2a and SmMYC2b played similar but irreplaceable roles in regulating the biosynthesis of tanshinones and phenolic acids in Salvia miltiorrhiza

(2016) Yangyun Zhou et al.   Scientific Reports

Cloning and functional characterization of an isopentenyl diphosphate isomerase gene fromTripterygium wilfordii

(2015) Yuru Tong et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Molecular Cloning and Characterization of DXS and DXR Genes in the Terpenoid Biosynthetic Pathway of Tripterygium wilfordii

(2015) Yuru Tong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of geranylgeranyl diphosphate synthase genes from Tripterygium wilfordii

(2015) Meng Zhang et al.   PLANT CELL REPORTS

Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4

(2015) Sangram K. Lenka et al.   Frontiers in Plant Science

Cloning and Characterisation of the Gene Encoding 3-Hydroxy-3-Methylglutaryl-CoA Synthase in Tripterygium wilfordii

(2014) Yu-Jia Liu et al.   MOLECULES

A bHLH-Type Transcription Factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, Acts as a Repressor to Negatively Regulate Jasmonate Signaling inArabidopsis

(2013) Masaru Nakata et al.   PLANT CELL

Basic Helix-Loop-Helix Transcription Factors JASMONATE-ASSOCIATED MYC2-LIKE1 (JAM1), JAM2, and JAM3 Are Negative Regulators of Jasmonate Responses in Arabidopsis

(2013) Y. Sasaki-Sekimoto et al.   PLANT PHYSIOLOGY

MYC2: The Master in Action

(2012) Kemal Kazan et al.   Molecular Plant

From Pioneers to Team Players: TGA Transcription Factors Provide a Molecular Link Between Different Stress Pathways

(2012) Christiane Gatz   MOLECULAR PLANT-MICROBE INTERACTIONS

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

(2012) Zhao-Li Zhou et al.   NATURAL PRODUCT REPORTS

ArabidopsisMYC2 Interacts with DELLA Proteins in Regulating Sesquiterpene Synthase Gene Expression

(2012) Gao-Jie Hong et al.   PLANT CELL

Aggregate cell suspension cultures of Tripterygium wilfordii Hook. f. for triptolide, wilforgine, and wilforine production

(2012) Guo-peng Miao et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Tobacco Transcription Factors NtMYC2a and NtMYC2b Form Nuclear Complexes with the NtJAZ1 Repressor and Regulate Multiple Jasmonate-Inducible Steps in Nicotine Biosynthesis

(2011) Hong-Bo Zhang et al.   Molecular Plant

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Isoquinoline Alkaloid Biosynthesis is Regulated by a Unique bHLH-Type Transcription Factor in Coptis japonica

(2011) Yasuyuki Yamada et al.   PLANT AND CELL PHYSIOLOGY

The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus

(2011) Hongtao Zhang et al.   PLANT JOURNAL

A functional genomics screen identifies diverse transcription factors that regulate alkaloid biosynthesis in Nicotiana benthamiana

(2010) Andrea T. Todd et al.   PLANT JOURNAL

Genome-Wide Classification and Evolutionary Analysis of the bHLH Family of Transcription Factors in Arabidopsis, Poplar, Rice, Moss, and Algae

(2010) L. Carretero-Paulet et al.   PLANT PHYSIOLOGY

DNA-Binding Study Identifies C-Box and Hybrid C/G-Box or C/A-Box Motifs as High-Affinity Binding Sites for STF1 and LONG HYPOCOTYL5 Proteins

(2008) Y. H. Song et al.   PLANT PHYSIOLOGY