Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Itaconate confers tolerance to late NLRP3 inflammasome activation

(2021) Monika Bambouskova et al.   Cell Reports

Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

(2021) Thekla Cordes et al.   Metabolites

Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO‐1 signaling pathway

(2020) Lingwen Gu et al.   IMMUNOLOGY AND CELL BIOLOGY

Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics

(2020) Lina Gao et al.   Scientific Reports

Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation

(2020) Sebastián A. Riquelme et al.   Cell Metabolism

Runners' metabolomic changes following marathon

(2020) Rengfei Shi et al.   Nutrition & Metabolism

Development of ion pairing LC-MS/MS method for itaconate and cis-aconitate in cell extract and cell media

(2020) Bo Tan et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages

(2020) Wei Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the evolutionary roots and physiological function of itaconate

(2020) Thekla Cordes et al.   CURRENT OPINION IN BIOTECHNOLOGY

Unusual Metabolites in a Patient with Isovaleric Acidemia

(2019) Irene De Biase et al.   CLINICAL CHEMISTRY

Targeted metabolomics to investigate antimicrobial activity of itaconic acid in marine molluscs

(2019) Thao Van Nguyen et al.   Metabolomics

The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry

(2019) Manoj Khadka et al.   Biomolecules

Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways

(2019) Caijun Zhao et al.   MICROBIAL PATHOGENESIS

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis

(2019) Fangfang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunomodulatory Potential of the Metabolite Itaconate

(2019) Alexander Hooftman et al.   TRENDS IN IMMUNOLOGY

Serum Levels of Mitochondrial and Microbial Metabolites Reflect Mitochondrial Dysfunction in Different Stages of Sepsis

(2019) Beloborodova et al.   Metabolites

Porphyromonas gingivalis triggers inflammatory responses in periodontal ligament cells by succinate-succinate dehydrogenase–HIF–1α axis

(2019) Wenqi Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of host genotype and Eimeria acervulina infection on the metabolome of meat-type chickens

(2019) Samuel E. Aggrey et al.   PLoS One

A likely protective effect of dimethyl itaconate on cerebral ischemia/reperfusion injury

(2019) Di Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Urinary metabolomics predict the severity of overactive bladder syndrome in an aging female population

(2019) Abubakr H. Mossa et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury

(2019) Thekla Cordes et al.   Molecular Metabolism

Squalene Synthase Deficiency: Clinical, Biochemical, and Molecular Characterization of a Defect in Cholesterol Biosynthesis

(2018) David Coman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Serum metabolic profiling of type 2 diabetes mellitus in Chinese adults using an untargeted GC/TOFMS

(2018) Huijuan Wang et al.   CLINICA CHIMICA ACTA

Regulatory responses of hepatocytes, macrophages and vascular endothelial cells to magnesium deficiency

(2018) Mei Shigematsu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic and immunological responses of male and female new Zealand Greenshell™ mussels (Perna canaliculus) infected with Vibrio sp.

(2018) Thao V. Nguyen et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Itaconic acid indicates cellular but not systemic immune system activation

(2018) Johannes Meiser et al.   Oncotarget

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome

(2018) Changzhuan Shao et al.   Polymers

Exploration of potential biomarkers and related biological pathways for PCB exposure in maternal and cord serum: A pilot birth cohort study in Chiba, Japan

(2017) Akifumi Eguchi et al.   ENVIRONMENT INTERNATIONAL

Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly

(2017) Mahmoud ElAzzouny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pentafluorobenzyl bromide—A versatile derivatization agent in chromatography and mass spectrometry: I. Analysis of inorganic anions and organophosphates

(2017) Dimitrios Tsikas   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

1 H NMR-based metabolomics study for identifying urinary biomarkers and perturbed metabolic pathways associated with severity of IgA nephropathy: a pilot study

(2017) Shiva Kalantari et al.   MAGNETIC RESONANCE IN CHEMISTRY

Metabolomics and lipidomics analyses by 1 H nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis

(2017) Ljubica Tasic et al.   SCHIZOPHRENIA RESEARCH

A metabolomics approach for predicting the response to intravenous iron therapy in peritoneal dialysis patients with anemia

(2017) Qiong Wu et al.   RSC Advances

Serum Metabolomics Analysis Reveals a Distinct Metabolic Profile of Patients with Primary Biliary Cholangitis

(2017) Juan Hao et al.   Scientific Reports

Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus

(2016) Mei Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis

(2016) Filippos Michopoulos et al.   JOURNAL OF PROTEOME RESEARCH

Stimulated Whole Blood Cytokine Release as a Biomarker of Immunosuppression in the Critically Ill

(2016) Elisabetta Segre et al.   SHOCK

Targeted serum metabolite profiling and sequential metabolite ratio analysis for colorectal cancer progression monitoring

(2015) Jiangjiang Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus

(2014) Jamie V. de Seymour et al.   ACTA DIABETOLOGICA

Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection

(2014) Xiaoyang Zhu et al.   JOURNAL OF PROTEOME RESEARCH

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

UPLC-ESI-QTOF/MS and multivariate data analysis for blood plasma and serum metabolomics: Effect of experimental artefacts and anticoagulant

(2013) Thaer Barri et al.   ANALYTICA CHIMICA ACTA

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

1H NMR-based Metabolomic Profiling in Mice Infected withMycobacterium tuberculosis

(2011) Ji-Hyun Shin et al.   JOURNAL OF PROTEOME RESEARCH

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY