Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO‐1 signaling pathway

EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways

(2019) Guang Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways

(2019) Caijun Zhao et al.   MICROBIAL PATHOGENESIS

Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection

(2018) Sharmila Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor

(2018) Yangyang Zhang et al.   Scientific Reports

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Itaconate: an emerging determinant of inflammation in activated macrophages

(2018) Xiao‐Hua Yu et al.   IMMUNOLOGY AND CELL BIOLOGY

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

(2016) Harding H. Luan et al.   Cell Metabolism

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo

(2016) Aniket Nikam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

(2015) Thekla Cordes et al.   Annual Review of Nutrition

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Indoleamine 2,3-Dioxygenase Is Involved in the Inflammation Response of Corneal Epithelial Cells to Aspergillus fumigatus Infections

(2015) Nan Jiang et al.   PLoS One

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents

(2014) Hong-Leong Cheah et al.   PLoS One

The role of the Nrf2-mediated defense system in corneal epithelial wound healing

(2013) Ryuhei Hayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis

(2010) Joydeb Kumar Kundu et al.   PHARMACEUTICAL RESEARCH

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

(2009) Norihiro Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS