Spinal Muscular Atrophy after Nusinersen Therapy: Improved Physiology in Pediatric Patients with No Significant Change in Urine, Serum, and Liquor 1H-NMR Metabolomes in Comparison to an Age-Matched, Healthy Cohort
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Spinal Muscular Atrophy after Nusinersen Therapy: Improved Physiology in Pediatric Patients with No Significant Change in Urine, Serum, and Liquor 1H-NMR Metabolomes in Comparison to an Age-Matched, Healthy Cohort
Authors
Keywords
-
Journal
Metabolites
Volume 11, Issue 4, Pages 206
Publisher
MDPI AG
Online
2021-03-30
DOI
10.3390/metabo11040206
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- New treatments in spinal muscular atrophy: an overview of currently available data
- (2020) Sithara Ramdas et al. EXPERT OPINION ON PHARMACOTHERAPY
- Overturning the Paradigm of Spinal Muscular Atrophy as just a Motor Neuron Disease
- (2020) Crystal Jing Jing Yeo et al. PEDIATRIC NEUROLOGY
- The Identification of Novel Biomarkers Is Required to Improve Adult SMA Patient Stratification, Diagnosis and Treatment
- (2020) Piera Smeriglio et al. Journal of Personalized Medicine
- Nusinersen treatment significantly improves hand grip strength, hand motor function and MRC sum scores in adult patients with spinal muscular atrophy types 3 and 4
- (2020) Bram De Wel et al. JOURNAL OF NEUROLOGY
- Children and young adults with spinal muscular atrophy treated with nusinersen
- (2020) Damjan Osredkar et al. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
- Systems View of Deconditioning During Spaceflight Simulation in the PlanHab Project: The Departure of Urine 1 H-NMR Metabolomes From Healthy State in Young Males Subjected to Bedrest Inactivity and Hypoxia
- (2020) Robert Šket et al. Frontiers in Physiology
- NMR Spectroscopy for Metabolomics Research
- (2019) Abdul-Hamid Emwas et al. Metabolites
- Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study
- (2019) Darryl C. De Vivo et al. NEUROMUSCULAR DISORDERS
- Serum creatinine is a biomarker of progressive denervation in spinal muscular atrophy
- (2019) Christiano R.R. Alves et al. NEUROLOGY
- 1 H NMR metabolomics of microbial metabolites in the four MW agricultural biogas plant reactors: A case study of inhibition mirroring the acute rumen acidosis symptoms
- (2018) Boštjan Murovec et al. JOURNAL OF ENVIRONMENTAL MANAGEMENT
- MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis
- (2018) Jasmine Chong et al. NUCLEIC ACIDS RESEARCH
- Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis
- (2018) Robert Šket et al. Frontiers in Physiology
- Evidence in focus: Nusinersen use in spinal muscular atrophy
- (2018) David Michelson et al. NEUROLOGY
- Nusinersen for the treatment of spinal muscular atrophy
- (2017) Claudia A. Chiriboga Expert Review of Neurotherapeutics
- Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy
- (2017) David R Corey NATURE NEUROSCIENCE
- HMDB 4.0: the human metabolome database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Nusinersen for the treatment of spinal muscular atrophy
- (2017) Claudia A. Chiriboga Expert Review of Neurotherapeutics
- Hypoxia and Inactivity Related Physiological Changes (Constipation, Inflammation) Are Not Reflected at the Level of Gut Metabolites and Butyrate Producing Microbial Community: The PlanHab Study
- (2017) Robert Šket et al. Frontiers in Physiology
- Hypoxia and inactivity related physiological changes precede or take place in absence of significant rearrangements in bacterial community structure: The PlanHab randomized trial pilot study
- (2017) Robert Šket et al. PLoS One
- Dark matter in host-microbiome metabolomics: Tackling the unknowns–A review
- (2017) B.Y. Loulou Peisl et al. ANALYTICA CHIMICA ACTA
- Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study
- (2016) Richard S Finkel et al. LANCET
- Results from a phase 1 study of nusinersen (ISIS-SMNRx) in children with spinal muscular atrophy
- (2016) Claudia A. Chiriboga et al. NEUROLOGY
- Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
- (2016) Henrik M. Roager et al. Nature Microbiology
- Methane Yield Database: Online infrastructure and bioresource for methane yield data and related metadata
- (2015) Boštjan Murovec et al. BIORESOURCE TECHNOLOGY
- Forecasting individual breast cancer risk using plasma metabolomics and biocontours
- (2015) Rasmus Bro et al. Metabolomics
- Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties
- (2015) Laura Marín et al. Biomed Research International
- Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children
- (2015) Chenhong Zhang et al. EBioMedicine
- Accurate, Fully-Automated NMR Spectral Profiling for Metabolomics
- (2015) Siamak Ravanbakhsh et al. PLoS One
- Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters
- (2014) Paula Hoff et al. Cellular & Molecular Immunology
- Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals
- (2014) Jacob Tveiten Bjerrum et al. Metabolomics
- Metabolic Phenotyping and Systems Biology Approaches to Understanding Metabolic Syndrome and Fatty Liver Disease
- (2013) Marc–Emmanuel Dumas et al. GASTROENTEROLOGY
- Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners
- (2013) David C. Nieman et al. JOURNAL OF PROTEOME RESEARCH
- NMR and pattern recognition methods in metabolomics: From data acquisition to biomarker discovery: A review
- (2012) Agnieszka Smolinska et al. ANALYTICA CHIMICA ACTA
- Antisense-based therapy for the treatment of spinal muscular atrophy
- (2012) Frank Rigo et al. JOURNAL OF CELL BIOLOGY
- Pan-ethnic carrier screening and prenatal diagnosis for spinal muscular atrophy: clinical laboratory analysis of >72 400 specimens
- (2011) Elaine A Sugarman et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model
- (2010) Y. Hua et al. GENES & DEVELOPMENT
- The Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND): Test development and reliability
- (2010) A.M. Glanzman et al. NEUROMUSCULAR DISORDERS
- Spinal muscular atrophy
- (2008) Mitchell R Lunn et al. LANCET
- Human metabolic phenotype diversity and its association with diet and blood pressure
- (2008) Elaine Holmes et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started