Spinal Muscular Atrophy after Nusinersen Therapy: Improved Physiology in Pediatric Patients with No Significant Change in Urine, Serum, and Liquor 1H-NMR Metabolomes in Comparison to an Age-Matched, Healthy Cohort

New treatments in spinal muscular atrophy: an overview of currently available data

(2020) Sithara Ramdas et al.   EXPERT OPINION ON PHARMACOTHERAPY

Overturning the Paradigm of Spinal Muscular Atrophy as just a Motor Neuron Disease

(2020) Crystal Jing Jing Yeo et al.   PEDIATRIC NEUROLOGY

The Identification of Novel Biomarkers Is Required to Improve Adult SMA Patient Stratification, Diagnosis and Treatment

(2020) Piera Smeriglio et al.   Journal of Personalized Medicine

Nusinersen treatment significantly improves hand grip strength, hand motor function and MRC sum scores in adult patients with spinal muscular atrophy types 3 and 4

(2020) Bram De Wel et al.   JOURNAL OF NEUROLOGY

Children and young adults with spinal muscular atrophy treated with nusinersen

(2020) Damjan Osredkar et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Systems View of Deconditioning During Spaceflight Simulation in the PlanHab Project: The Departure of Urine 1 H-NMR Metabolomes From Healthy State in Young Males Subjected to Bedrest Inactivity and Hypoxia

(2020) Robert Šket et al.   Frontiers in Physiology

NMR Spectroscopy for Metabolomics Research

(2019) Abdul-Hamid Emwas et al.   Metabolites

Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study

(2019) Darryl C. De Vivo et al.   NEUROMUSCULAR DISORDERS

Serum creatinine is a biomarker of progressive denervation in spinal muscular atrophy

(2019) Christiano R.R. Alves et al.   NEUROLOGY

1 H NMR metabolomics of microbial metabolites in the four MW agricultural biogas plant reactors: A case study of inhibition mirroring the acute rumen acidosis symptoms

(2018) Boštjan Murovec et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis

(2018) Robert Šket et al.   Frontiers in Physiology

Evidence in focus: Nusinersen use in spinal muscular atrophy

(2018) David Michelson et al.   NEUROLOGY

Nusinersen for the treatment of spinal muscular atrophy

(2017) Claudia A. Chiriboga   Expert Review of Neurotherapeutics

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy

(2017) David R Corey   NATURE NEUROSCIENCE

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Nusinersen for the treatment of spinal muscular atrophy

(2017) Claudia A. Chiriboga   Expert Review of Neurotherapeutics

Hypoxia and Inactivity Related Physiological Changes (Constipation, Inflammation) Are Not Reflected at the Level of Gut Metabolites and Butyrate Producing Microbial Community: The PlanHab Study

(2017) Robert Šket et al.   Frontiers in Physiology

Hypoxia and inactivity related physiological changes precede or take place in absence of significant rearrangements in bacterial community structure: The PlanHab randomized trial pilot study

(2017) Robert Šket et al.   PLoS One

Dark matter in host-microbiome metabolomics: Tackling the unknowns–A review

(2017) B.Y. Loulou Peisl et al.   ANALYTICA CHIMICA ACTA

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

(2016) Richard S Finkel et al.   LANCET

Results from a phase 1 study of nusinersen (ISIS-SMNRx) in children with spinal muscular atrophy

(2016) Claudia A. Chiriboga et al.   NEUROLOGY

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

(2016) Henrik M. Roager et al.   Nature Microbiology

Methane Yield Database: Online infrastructure and bioresource for methane yield data and related metadata

(2015) Boštjan Murovec et al.   BIORESOURCE TECHNOLOGY

Forecasting individual breast cancer risk using plasma metabolomics and biocontours

(2015) Rasmus Bro et al.   Metabolomics

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children

(2015) Chenhong Zhang et al.   EBioMedicine

Accurate, Fully-Automated NMR Spectral Profiling for Metabolomics

(2015) Siamak Ravanbakhsh et al.   PLoS One

Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters

(2014) Paula Hoff et al.   Cellular & Molecular Immunology

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals

(2014) Jacob Tveiten Bjerrum et al.   Metabolomics

Metabolic Phenotyping and Systems Biology Approaches to Understanding Metabolic Syndrome and Fatty Liver Disease

(2013) Marc–Emmanuel Dumas et al.   GASTROENTEROLOGY

Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners

(2013) David C. Nieman et al.   JOURNAL OF PROTEOME RESEARCH

NMR and pattern recognition methods in metabolomics: From data acquisition to biomarker discovery: A review

(2012) Agnieszka Smolinska et al.   ANALYTICA CHIMICA ACTA

Antisense-based therapy for the treatment of spinal muscular atrophy

(2012) Frank Rigo et al.   JOURNAL OF CELL BIOLOGY

Pan-ethnic carrier screening and prenatal diagnosis for spinal muscular atrophy: clinical laboratory analysis of >72 400 specimens

(2011) Elaine A Sugarman et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

(2010) Y. Hua et al.   GENES & DEVELOPMENT

The Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND): Test development and reliability

(2010) A.M. Glanzman et al.   NEUROMUSCULAR DISORDERS

Spinal muscular atrophy

(2008) Mitchell R Lunn et al.   LANCET

Human metabolic phenotype diversity and its association with diet and blood pressure

(2008) Elaine Holmes et al.   NATURE