Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice

(2019) Jiehua Zhou et al.   MOLECULAR THERAPY

Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation

(2019) Tomohiko Murakami et al.   JOURNAL OF IMMUNOLOGY

The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

(2019) Satoru Miyagi et al.   BLOOD

Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation

(2019) Silvia Mas-Peiro et al.   EUROPEAN HEART JOURNAL

Role of Inflammatory Cell Subtypes in Heart Failure

(2019) Derek Strassheim et al.   Journal of Immunology Research

Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis

(2019) Lena Dorsheimer et al.   HAEMATOLOGICA

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Clonal hematopoiesis as a model for premalignant changes during aging

(2019) David P. Steensma et al.   EXPERIMENTAL HEMATOLOGY

Clonal hematopoiesis, aging, and cardiovascular diseases

(2019) Evangelia Pardali et al.   EXPERIMENTAL HEMATOLOGY

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

(2018) Robert L. Bowman et al.   Cell Stem Cell

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

(2018) Xingli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis

(2018) Christopher Maximilian Arends et al.   LEUKEMIA

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

(2018) Sergi Cuartero et al.   NATURE IMMUNOLOGY

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

(2018) Zhiyang Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

(2016) R. Avellino et al.   BLOOD

The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway

(2016) Lin Dong et al.   CNS Neuroscience & Therapeutics

Progranulin Controls Sepsis via C/EBPα-RegulatedIl10Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation

(2016) Wenjun Yan et al.   JOURNAL OF IMMUNOLOGY

Gnb isoforms control a signaling pathway comprising Rac1, Plc 2, and Plc 3 leading to LFA-1 activation and neutrophil arrest in vivo

(2015) H. Block et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

A genome-scale in vivo loss-of-function screen identifiesPhf6as a lineage-specific regulator of leukemia cell growth

(2015) Corbin E. Meacham et al.   GENES & DEVELOPMENT

The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

(2015) Michel DuPage et al.   IMMUNITY

EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion

(2015) Xiang-Ping Yang et al.   Scientific Reports

c-Rel Regulates Ezh2 Expression in Activated Lymphocytes and Malignant Lymphoid Cells

(2014) Wen Hao Neo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

(2014) Daisuke Kurotaki et al.   Nature Communications

Cornelia de Lange individuals with new and recurrentSMC1Amutations enhance delineation of mutation repertoire and phenotypic spectrum

(2013) Cristina Gervasini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA

(2013) TIING JEN LOH et al.   ONCOLOGY REPORTS

Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

(2013) V. R. Moulton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

Triptolide Inhibits IL-12/IL-23 Expression in APCs via CCAAT/Enhancer-Binding Protein  

(2010) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins

(2008) E. Y. Choi et al.   BLOOD