Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

(2020) T Kissel et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

(2020) Igor Pravst et al.   Nutrients

Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges

(2020) Rong Yu et al.   Frontiers in Endocrinology

Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis

(2020) Behnam Khalilian et al.   JOURNAL OF MOLECULAR HISTOLOGY

Bioavailability and Sustained Plasma Concentrations of CoQ10 in Healthy Volunteers by a Novel Oral Timed-Release Preparation

(2019) Alessio Martucci et al.   Nutrients

Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

(2019) Seyed Mostafa Nachvak et al.   CLINICAL RHEUMATOLOGY

The coenzyme Q10 analog idebenone attenuates murine lupus by improving mitochondrial metabolism and reducing inflammation

(2019) Luz P. Blanco et al.   Arthritis & Rheumatology

Oxidative Stress in Rheumatoid Arthritis: What the Future Might Hold regarding Novel Biomarkers and Add-On Therapies

(2019) Lucas José Sá da Fonseca et al.   Oxidative Medicine and Cellular Longevity

What are the dominant cytokines in early rheumatoid arthritis?

(2018) Laura A. Ridgley et al.   CURRENT OPINION IN RHEUMATOLOGY

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Oxidative stress in autoimmune rheumatic diseases

(2018) Miranda J. Smallwood et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Combination with Probiotic Complex, Zinc, and Coenzyme Q10 Attenuates Autoimmune Arthritis by Regulation of Th17/Treg Balance

(2018) Seon-Young Lee et al.   JOURNAL OF MEDICINAL FOOD

Diagnosis and Management of the Antiphospholipid Syndrome

(2018) David Garcia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Excitotoxins, Mitochondrial and Redox Disturbances in Multiple Sclerosis

(2017) Cecilia Rajda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo evidence of oxidative stress in brains of patients with progressive multiple sclerosis

(2017) In-Young Choi et al.   Multiple Sclerosis Journal

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

(2017) Zewen Liu et al.   Oxidative Medicine and Cellular Longevity

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis

(2017) Jonathan A. Stefely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

(2017) Giang T. Nguyen et al.   Frontiers in Cellular and Infection Microbiology

In vivo evidence of oxidative stress in brains of patients with progressive multiple sclerosis

(2017) In-Young Choi et al.   Multiple Sclerosis Journal

In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis

(2017) He Meng et al.   Arthritis & Rheumatology

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Diabetes mellitus and oxidative stress—A concise review

(2016) Ullah Asmat et al.   SAUDI PHARMACEUTICAL JOURNAL

Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review

(2016) Celia María Quiñonez-Flores et al.   Biomed Research International

Correlation of Lipid Peroxidation and Glutathione Levels with severity of Systemic Lupus Erythematosus: a Pilot study from Single Center

(2016) Karunrat Tewthanom   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis

(2016) Somaiya Mateen et al.   PLoS One

‘Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients’

(2016) C. Pérez-Sánchez et al.   Scientific Reports

Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial

(2015) Hadi Abdollahzad et al.   ARCHIVES OF MEDICAL RESEARCH

Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice

(2015) JooYeon Jhun et al.   IMMUNOLOGY LETTERS

Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis

(2015) JooYeon Jhun et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Combination of coenzyme Q10 with methotrexate suppresses Freund's complete adjuvant-induced synovial inflammation with reduced hepatotoxicity in rats: Effect on oxidative stress and inflammation

(2015) Mona K. Tawfik   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondrial delivery of Coenzyme Q 10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

(2015) Yuma Yamada et al.   JOURNAL OF CONTROLLED RELEASE

Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial

(2015) Meisam Sanoobar et al.   NUTRITIONAL NEUROSCIENCE

Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome

(2015) Srilakshmi Yalavarthi et al.   Arthritis & Rheumatology

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

Gene profiling reveals specific molecular pathways in the pathogenesis of atherosclerosis and cardiovascular disease in antiphospholipid syndrome, systemic lupus erythematosus and antiphospholipid syndrome with lupus

(2014) Carlos Perez-Sanchez et al.   ANNALS OF THE RHEUMATIC DISEASES

Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment

(2014) Patricia Ruiz-Limon et al.   ANNALS OF THE RHEUMATIC DISEASES

Anticyclic Citrullinated Protein Antibodies Are Implicated in the Development of Cardiovascular Disease in Rheumatoid Arthritis

(2014) Nuria Barbarroja et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity

(2014) H. Brauner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Strategies for oral delivery and mitochondrial targeting of CoQ10

(2014) Noha M. Zaki   DRUG DELIVERY

Oxidative stress in rheumatoid arthritis patients: relationship to diseases activity

(2014) Mirjana Veselinovic et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Is CoQ a membrane stabilizer?

(2014) Catherine F Clarke et al.   Nature Chemical Biology

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

(2014) Meisam Sanoobar et al.   NUTRITIONAL NEUROSCIENCE

Role of Toll-like Receptors 2 and 4 in Mediating Endothelial Dysfunction and Arterial Remodeling in Primary Arterial Antiphospholipid Syndrome

(2014) Ygal Benhamou et al.   Arthritis & Rheumatology

Neutrophil Extracellular Trap-Derived Enzymes Oxidize High-Density Lipoprotein: An Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus

(2014) Carolyne K. Smith et al.   Arthritis & Rheumatology

Prophylactic and Antinociceptive Effects of Coenzyme Q10 on Diabetic Neuropathic Pain in a Mouse Model of Type 1 Diabetes

(2013) Yan Ping Zhang et al.   ANESTHESIOLOGY

Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases

(2013) Teresa Fiorentino et al.   CURRENT PHARMACEUTICAL DESIGN

Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing–remitting multiple sclerosis

(2013) Meisam Sanoobar et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Inflammation and oxidative stress in angiogenesis and vascular disease

(2013) Young-Woong Kim et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Pathogenesis of the Antiphospholipid Syndrome

(2013) Bill Giannakopoulos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus

(2013) Vojislav Jovanović et al.   PLoS One

Involvement of Oxidative Stress in Occurrence of Relapses in Multiple Sclerosis: The Spectrum of Oxidatively Modified Serum Proteins Detected by Proteomics and Redox Proteomics Analysis

(2013) Ada Fiorini et al.   PLoS One

NETs: the missing link between cell death and systemic autoimmune diseases?

(2013) Erika Darrah et al.   Frontiers in Immunology

SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB

(2012) Chun-Juan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment

(2012) C. Perez-Sanchez et al.   BLOOD

Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE

(2012) Sema Yılmaz et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

8-Isoprostane, prostaglandin E2, C-reactive protein and serum amyloid A as markers of inflammation and oxidative stress in antiphospholipid syndrome: a pilot study

(2012) Savino Sciascia et al.   INFLAMMATION RESEARCH

Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases

(2012) Jason S. Knight et al.   Frontiers in Immunology

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells

(2011) N. Prinz et al.   BLOOD

Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies

(2011) N. Satta et al.   BLOOD

Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes

(2011) Meghan M. Delmastro et al.   Clinical & Developmental Immunology

Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues

(2011) Cristina Parrado-Fernández et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

(2011) Karly C. Sourris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rac2 is required for the formation of neutrophil extracellular traps

(2011) Michael Byung H. Lim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential expression of protease-activated receptors in monocytes from patients with primary antiphospholipid syndrome

(2010) Chary López-Pedrera et al.   ARTHRITIS AND RHEUMATISM

Coenzyme Q – Biosynthesis and functions

(2010) Magnus Bentinger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Coenzyme Q10 Contents in Foods and Fortification Strategies

(2010) Igor Pravst et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Therapeutic use of coenzyme Q10and coenzyme Q10-related compounds and formulations

(2010) Jose M Villalba et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Oxidative stress in systemic lupus erythematosus: Relationship to Th1 cytokine and disease activity

(2010) Dilip Shah et al.   IMMUNOLOGY LETTERS

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

MicroRNAs as biomarkers in rheumatic diseases

(2010) Ilias Alevizos et al.   Nature Reviews Rheumatology

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced reactivity to malondialdehyde-modified proteins by systemic lupus erythematosus autoantibodies

(2010) R Ben Mansour et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Interaction between oxidative stress and high-density lipoprotein cholesterol is associated with severity of coronary artery calcification in rheumatoid arthritis

(2010) Young Hee Rho et al.   ARTHRITIS CARE & RESEARCH

Neutrophil Extracellular Traps: How to Generate and Visualize Them

(2010) Volker Brinkmann et al.   Jove-Journal of Visualized Experiments

The evolution of coenzyme Q

(2009) Frederick L. Crane   BIOFACTORS

Safety assessment of coenzyme Q10(CoQ10)

(2009) Takayoshi Hidaka et al.   BIOFACTORS

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Rheumatoid Arthritis

(2009) Ivy A. Ku et al.   CIRCULATION JOURNAL

Total plasma antioxidants in first-degree relatives of patients with insulin-dependent diabetes

(2009) B. Ročić et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Vascular Abnormalities, Paraoxonase Activity, and Dysfunctional HDL in Primary Antiphospholipid Syndrome

(2009) Marietta Charakida   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice

(2009) Nathalie Sumien et al.   JOURNAL OF NUTRITION

Atherosclerosis in autoimmune diseases

(2009) Eiji Matsuura et al.   Current Rheumatology Reports

Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?

(2008) Helen R. Griffiths   AUTOIMMUNITY REVIEWS

Autoimmunity and oxidatively modified autoantigens

(2008) Biji T. Kurien et al.   AUTOIMMUNITY REVIEWS

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased levels of autoantibodies against catalase and superoxide dismutase associated with oxidative stress in patients with rheumatoid arthritis and systemic lupus erythematosus

(2008) R. Ben Mansour et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY