Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations

Oxidative stress – A unifying paradigm in hypertension

(2020) Rhian M. Touyz et al.   CANADIAN JOURNAL OF CARDIOLOGY

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics

(2020) Maryam Raeeszadeh-Sarmazdeh et al.   Cells

2020 International Society of Hypertension Global Hypertension Practice Guidelines

(2020) Thomas Unger et al.   HYPERTENSION

The prognostic value of elevated matrix metalloproteinase-9 in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: A two-year prospective study

(2020) Mustafa Umut Somuncu et al.   Revista Portuguesa de Cardiologia

Denosumab Regulates Gut Microbiota Composition and Cytokines in Dinitrobenzene Sulfonic Acid (DNBS)-Experimental Colitis

(2020) Azin Khafipour et al.   Frontiers in Microbiology

HPLC-PDA-MS/MS profiling of secondary metabolites from Opuntia ficus-indica cladode, peel and fruit pulp extracts and their antioxidant, neuroprotective effect in rats with aluminum chloride induced neurotoxicity

(2020) Seham S. El-Hawary et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure

(2020) B.R. Mattos et al.   BIOCHEMICAL PHARMACOLOGY

Circulating Levels of Inflammatory and Metabolic Biomarkers and Risk of Esophageal Adenocarcinoma and Barrett Esophagus: Systematic Review and Meta-analysis

(2020) Shao-Hua Xie et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time

(2020) M. Weckmann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Antioxidant and antihypertensive responses to oral nitrite involves activation of the Nrf2 pathway

(2019) Jefferson H. Amaral et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension

(2018) Sherliane C. Pereira et al.   ATHEROSCLEROSIS

Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis

(2018) David L. Gossage et al.   CLINICAL THERAPEUTICS

Andecaliximab [Anti-matrix Metalloproteinase-9] Induction Therapy for Ulcerative Colitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2/3 Study in Patients With Moderate to Severe Disease

(2018) William J Sandborn et al.   Journal of Crohns & Colitis

A Phase 2, Randomized, Placebo-Controlled Study Evaluating Matrix Metalloproteinase-9 Inhibitor, Andecaliximab, in Patients With Moderately to Severely Active Crohn’s Disease

(2018) Stefan Schreiber et al.   Journal of Crohns & Colitis

Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease

(2018) Xiaohong Liu et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction

(2018) Alejandro F. Prado et al.   Redox Biology

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

(2018) Isola A.M. Brown et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Nitric Oxide in the Cardiovascular and Renal Systems

(2018) Ashfaq Ahmad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects

(2018) Elen Rizzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Jeffrey D Stanaway et al.   LANCET

Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension

(2018) Marcela M. Blascke de Mello et al.   VASCULAR PHARMACOLOGY

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Usefulness of plasma matrix metalloproteinase-9 levels in prediction of in-hospital mortality in patients who received emergent percutaneous coronary artery intervention following myocardial infarction

(2017) Jia-Jun Zhu et al.   Oncotarget

Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension

(2016) Vanessa de Almeida Belo et al.   BIOCHEMICAL PHARMACOLOGY

Crosstalk between obesity and MMP-9 in cardiac remodelling –a cross-sectional study in apparent treatment-resistant hypertension

(2016) Alessandra Mileni Versuti Ritter et al.   BLOOD PRESSURE

Vascular structural and functional changes: their association with causality in hypertension: models, remodeling and relevance

(2016) Robert MKW Lee et al.   HYPERTENSION RESEARCH

Matrix Metalloproteinase-2 Polymorphisms in Chronic Heart Failure: Relationship with Susceptibility and Long-Term Survival

(2016) Ana Rubia C. Beber et al.   PLoS One

Matrix Metalloproteinase 2 as a Potential Mediator of Vascular Smooth Muscle Cell Migration and Chronic Vascular Remodeling in Hypertension

(2015) V.A. Belo et al.   JOURNAL OF VASCULAR RESEARCH

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver

(2015) S. Hernandez-Anzaldo et al.   Journal of the American Heart Association

Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Inflammation and Fever

(2015) E. Berry et al.   Journal of the American Heart Association

NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis

(2015) Mariarosaria Santillo et al.   Frontiers in Physiology

Atorvastatin and sildenafil decrease vascular TGF-β levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension

(2015) Danielle A. Guimarães et al.   Redox Biology

The Matrix Metalloproteinase 2-1575 gene Polymorphism is Associated with the Risk of Developing Myocardial Infarction in Mexican Patients

(2015) Nonanzit Pérez-Hernández et al.   Journal of Atherosclerosis and Thrombosis

Matrix Metalloproteinases are Involved in Cardiovascular Diseases

(2014) Aline Azevedo et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Inducible Nitric Oxide Synthase as a Possible Target in Hypertension

(2014) Gustavo Oliveira-Paula et al.   CURRENT DRUG TARGETS

β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy

(2014) Elen Rizzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2

(2014) Katarina Smiljanic et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance

(2013) Shane O'Sullivan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Multicentric osteolysis with nodulosis and arthropathy (MONA) with cardiac malformation, mimicking polyarticular juvenile idiopathic arthritis: case report and literature review

(2013) Filip Christian Castberg et al.   EUROPEAN JOURNAL OF PEDIATRICS

Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

(2013) Anna Laura Jacob-Ferreira et al.   PLoS One

Pathophysiology of Vascular Remodeling in Hypertension

(2013) Nicolás F. Renna et al.   International Journal of Hypertension

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

(2012) Aurelie Nguyen Dinh Cat et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-β in renovascular hypertension-induced cardiac hypertrophy

(2012) Elen Rizzi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling

(2012) Alisson Martins-Oliveira et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Immediate administration of atorvastatin decreased the serum MMP-2 level and improved the prognosis for acute heart failure

(2012) Akihiro Shirakabe et al.   Journal of Cardiology

Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability

(2012) Michele M. Castro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Induced by Oxidative Stress Activates Innate Immunity

(2012) David H. Lovett et al.   PLoS One

Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension

(2011) SBA Cau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats

(2011) PR Nagareddy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction

(2011) Lennart Nilsson et al.   HEART

Nuclear Factor Kappa B and Matrix Metalloproteinase Induced Receptor Cleavage in the Spontaneously Hypertensive Rat

(2011) Kwan-I Sharon Wu et al.   HYPERTENSION

Endogenous nitric oxide formation correlates negatively with circulating matrix metalloproteinase (MMP)-2 and MMP-9 levels in black subjects

(2011) Ingrid F. Metzger et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Matrix metalloproteinases: Targets for doxycycline to prevent the vascular alterations of hypertension

(2011) Michele M. Castro et al.   PHARMACOLOGICAL RESEARCH

Associations Between Collagen Synthesis and Degradation and Aortic Function in Arterial Hypertension

(2010) D. A. Stakos et al.   AMERICAN JOURNAL OF HYPERTENSION

Matrix metalloproteinases cleave the β2-adrenergic receptor in spontaneously hypertensive rats

(2010) Stephen F. Rodrigues et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Doxycycline Dose-dependently Inhibits MMP-2-Mediated Vascular Changes in 2K1C Hypertension

(2010) Danielle A. Guimaraes et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension

(2010) CS Ceron et al.   BRITISH JOURNAL OF PHARMACOLOGY

Titin is a Target of Matrix Metalloproteinase-2

(2010) Mohammad A.M. Ali et al.   CIRCULATION

Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension

(2010) Diogo M. O. Marçal et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Episodes of Acute Heart Failure Syndrome Are Associated With Increased Levels of Troponin and Extracellular Matrix Markers

(2009) Andreia Biolo et al.   Circulation-Heart Failure

Polymorphisms of MMP-2 gene are associated with systolic heart failure prognosis

(2009) Yihong Hua et al.   CLINICA CHIMICA ACTA

Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension

(2009) Michele M. Castro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of matrix metalloproteinase-2 gene promoter polymorphism with myocardial infarction susceptibility in a Mexican population

(2009) Ivan Delgado-Enciso et al.   JOURNAL OF GENETICS

Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling

(2009) Michele M. Castro et al.   MATRIX BIOLOGY

Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione

(2008) Serena Viappiani et al.   BIOCHEMICAL PHARMACOLOGY

Hypertension and microvascular remodelling

(2008) François Feihl et al.   CARDIOVASCULAR RESEARCH

Inverse relationship between markers of nitric oxide formation and plasma matrix metalloproteinase-9 levels in healthy volunteers

(2008) Caroline Demacq et al.   CLINICA CHIMICA ACTA

A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects

(2008) Beyhan Tuysuz et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adaptation and remodeling of vascular wall; biomechanical response to hypertension

(2008) Kozaburo Hayashi et al.   Journal of the Mechanical Behavior of Biomedical Materials

Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats

(2007) Michele M. Castro et al.   ATHEROSCLEROSIS