Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway

(2020) Abdul Q. Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of miR-21/RECK in the inhibition of osteosarcoma by curcumin

(2020) Li Zhou et al.   MOLECULAR AND CELLULAR PROBES

ERK/MAPK signalling pathway and tumorigenesis (Review)

(2020) Yan‑Jun Guo et al.   Experimental and Therapeutic Medicine

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity

(2020) Fabiola Paciello et al.   Scientific Reports

Curcumin as an Anticancer Agent in Malignant Mesothelioma: A Review

(2020) Alfonso Baldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis

(2020) Wei Li et al.   ONCOLOGY REPORTS

Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial

(2020) Tatul Saghatelyan et al.   PHYTOMEDICINE

TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

(2020) Jie Cheng et al.   Nature Communications

miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway

(2020) Yancheng Pan et al.   Molecular Medicine Reports

LincROR Mediates the Suppressive Effects of Curcumin on Hepatocellular Carcinoma Through Inactivating Wnt/β-Catenin Signaling

(2020) Jiang Shao et al.   Frontiers in Pharmacology

Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells

(2020) Lei Xiang et al.   ONCOLOGY REPORTS

The clinical effect of Nano micelles containing curcumin as a therapeutic supplement in patients with COVID-19 and the immune responses balance changes following treatment: A structured summary of a study protocol for a randomised controlled trial

(2020) Mehdi Hassaniazad et al.   Trials

Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras‐Raf‐MAPK signalling

(2020) Yongye Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

miRNA-99a inhibits cell invasion and migration in liver cancer by directly targeting HOXA1

(2019) Changming Tao et al.   Oncology Letters

MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review)

(2019) Yong Wang et al.   Oncology Letters

miRNA-192-5p impacts the sensitivity of breast cancer cells to doxorubicin via targeting peptidylprolyl isomerase A

(2019) Yi Zhang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells

(2019) Zhanrong Qiang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

A Review of Curcumin and Its Derivatives as Anticancer Agents

(2019) Mhd Tomeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The relation between PI3K/AKT signalling pathway and cancer

(2019) Saeed Noorolyai et al.   GENE

The targeting of non‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review)

(2019) Yun Liu et al.   ONCOLOGY REPORTS

lncRNA‑NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA‑21

(2019) Qinglei Yang et al.   Oncology Letters

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

(2019) Yuening Xiang et al.   Cancer Medicine

MicroRNA-1246 regulates the radio-sensitizing effect of curcumin in bladder cancer cells via activating P53

(2019) Ran Xu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells

(2019) Faezeh Ghasemi et al.   PATHOLOGY RESEARCH AND PRACTICE

A Novel hMTR4‐PDIA3P1‐miR‐125/124‐TRAF6 Regulatory Axis and Its Function in NF‐ K B Signaling and Chemoresistance

(2019) Chen Xie et al.   HEPATOLOGY

Oncological role of HMGA2 (Review)

(2019) Shizhen Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The emerging role of the piRNA/piwi complex in cancer

(2019) Yongmei Liu et al.   Molecular Cancer

miR‑378a‑3p inhibits cellular proliferation and migration in glioblastoma multiforme by targeting tetraspanin 17

(2019) Xiao‑Bing Guo et al.   ONCOLOGY REPORTS

The Role of Non-coding RNAs in Oncology

(2019) Frank J. Slack et al.   CELL

Therapeutic potential of natural products in glioblastoma treatment: targeting key glioblastoma signaling pathways and epigenetic alterations

(2019) M. N. Abbas et al.   Clinical & Translational Oncology

Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers

(2019) Zintle Mbese et al.   MOLECULES

Curcumin and Cancer

(2019) Giordano et al.   Nutrients

Long Non-coding RNA DANCR as an Emerging Therapeutic Target in Human Cancers

(2019) Shi-Jia Jin et al.   Frontiers in Oncology

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

(2019) Guohua Zhu et al.   PHARMACEUTICAL BIOLOGY

Beneficial effects of nano‐curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double‐blind, placebo‐controlled clinical trial

(2019) Sara Asadi et al.   PHYTOTHERAPY RESEARCH

LncRNA HOXA-AS2 and its molecular mechanisms in human cancer

(2018) Jicai Wang et al.   CLINICA CHIMICA ACTA

Emerging Roles of Non-Coding RNA Transcription

(2018) Minna U. Kaikkonen et al.   TRENDS IN BIOCHEMICAL SCIENCES

MicroRNA‑206 regulates the epithelial‑mesenchymal transition and inhibits the invasion and metastasis of prostate cancer cells by targeting Annexin A2

(2018) Ning Yang et al.   Oncology Letters

Linc-ROR Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Functioning as a Competing Endogenous RNA for miR-138 and miR-145

(2018) Lu Feng et al.   Molecular Therapy-Nucleic Acids

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

(2018) Eléonore Toufektchan et al.   Cancers

MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1

(2018) Young Ran Park et al.   BIOSCIENCE REPORTS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

FGF18 Enhances Migration and the Epithelial-Mesenchymal Transition in Breast Cancer by Regulating Akt/GSK3β/Β-Catenin Signaling

(2018) Na Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

piRNA-Guided Genome Defense: From Biogenesis to Silencing

(2018) Benjamin Czech et al.   Annual Review of Genetics

Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway

(2018) Yaping Li et al.   BMC CANCER

Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells

(2018) Ajda Coker-Gurkan et al.   MOLECULAR BIOLOGY REPORTS

Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR

(2017) Te Liu et al.   GENE

Enhancement in in vitro anti-angiogenesis activity and cytotoxicity in lung cancer cell by pectin-PVP based curcumin particulates

(2017) Dinanath Gaikwad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

MicroRNA: A novel target of curcumin in cancer therapy

(2017) Hamed Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Curcumin-functionalized silk biomaterials for anti-aging utility

(2017) Lei Yang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Wnt/beta-catenin pathway: modulating anticancer immune response

(2017) Sachin Gopalkrishna Pai et al.   Journal of Hematology & Oncology

Curcumin: Structure-Activity Relationship Towards its Role as a Versatile Multi-Targeted Therapeutics

(2017) Manika Awasthi et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

TCF4/β‑catenin complex is directly upstream of FGF21 in mouse stomach cancer cells

(2017) Jihua Pei et al.   Experimental and Therapeutic Medicine

MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

(2017) Wende Li et al.   Oncotarget

Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

(2017) Huiqiang Dou et al.   Frontiers in Pharmacology

Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer

(2016) Zhongxing Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways

(2016) Xiaoming Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Non-coding RNAs as regulators in epigenetics

(2016) Jian-Wei Wei et al.   ONCOLOGY REPORTS

Natural products against cancer angiogenesis

(2016) El Bairi Khalid et al.   TUMOR BIOLOGY

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19

(2016) Gao Liu et al.   Oncology Letters

MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer

(2016) Liuqing Yang et al.   Protein & Cell

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Epigenetics and pharmacology

(2015) Barbara Stefanska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetics in lung cancer diagnosis and therapy

(2015) Aditi Mehta et al.   CANCER AND METASTASIS REVIEWS

Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer

(2015) Mingxiang Ye et al.   CANCER LETTERS

Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways

(2015) QINGHUA YAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML

(2015) Li Tan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer

(2015) Jens U. Marquardt et al.   JOURNAL OF HEPATOLOGY

The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

(2015) Muthu Shanmugam et al.   MOLECULES

Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro

(2015) Jian-Ye Zhang et al.   MOLECULES

Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway

(2015) HAI JIN et al.   ONCOLOGY REPORTS

MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2

(2015) Pu Zhang et al.   TOXICOLOGY LETTERS

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

(2015) Wenting Xu et al.   Cell Adhesion & Migration

Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation

(2015) Chengcao Sun et al.   Oncotarget

Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer

(2015) Hao Li et al.   Oncotarget

Functions of lncRNA HOTAIR in lung cancer

(2014) Gregory Loewen et al.   Journal of Hematology & Oncology

Curcumin Modulates miR-19/PTEN/AKT/p53 Axis to Suppress Bisphenol A-induced MCF-7 Breast Cancer Cell Proliferation

(2014) Xiaoting Li et al.   PHYTOTHERAPY RESEARCH

Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability

(2014) Bo Ram Seo et al.   PLoS One

microRNA-99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer

(2014) DEYAO WU et al.   Oncology Letters

The Curcumin Analog EF24 Targets NF-κB and miRNA-21, and Has Potent Anticancer Activity In Vitro and In Vivo

(2013) Chuan He Yang et al.   PLoS One

Uncovering the role of p53 splice variants in human malignancy: a clinical perspective

(2013) Jean-Christophe Bourdon et al.   OncoTargets and Therapy

Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells

(2012) Feng Yang et al.   FEBS Journal

Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer

(2012) Yan Xu et al.   Molecular Oncology

The JAK/STAT Pathway

(2012) D. A. Harrison   Cold Spring Harbor Perspectives in Biology

Curcumin Modulates MicroRNA-203-Mediated Regulation of the Src-Akt Axis in Bladder Cancer

(2011) S. Saini et al.   Cancer Prevention Research

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells

(2010) Wen-Feng Hua et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB in Breast Cancer Cells and Potentiates the Growth Inhibitory Effect of Paclitaxel in a Breast Cancer Nude Mice Model

(2009) Hee Joon Kang et al.   Breast Journal

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

MicroRNA-1/206 Targets c-Metand Inhibits Rhabdomyosarcoma Development

(2009) Dongsheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin and cancer: An “old-age” disease with an “age-old” solution

(2008) Preetha Anand et al.   CANCER LETTERS

HMGA2 gene is a promising target for ovarian cancer silencing therapy

(2008) Anastasia Malek et al.   INTERNATIONAL JOURNAL OF CANCER

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE