Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis

CTGF/CCN2 facilitates LRP4‐mediated formation of the embryonic neuromuscular junction

(2020) Bisei Ohkawara et al.   EMBO REPORTS

Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis

(2020) Thaddaeus Kwan et al.   Scientific Reports

Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a

(2019) Carlos González-Fernández et al.   MOLECULAR NEUROBIOLOGY

WNT signaling represses astrogliogenesis via Ngn2‐dependent direct suppression of astrocyte gene expression

(2019) Shuhui Sun et al.   GLIA

The presence of antibodies against low-density lipoprotein receptor-related protein 4 and impairment of neuromuscular junction in a Chinese cohort of amyotrophic lateral sclerosis

(2019) Lin Lei et al.   CHINESE MEDICAL JOURNAL

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

(2019) Tetsuya Akiyama et al.   EBioMedicine

The role of skeletal muscle in amyotrophic lateral sclerosis: a ‘dying‐back’ or ‘dying‐forward’ phenomenon?

(2019) Stavroula Tsitkanou et al.   JOURNAL OF PHYSIOLOGY-LONDON

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

(2019) Gina Picchiarelli et al.   NATURE NEUROSCIENCE

β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation

(2019) Cristina Pinto et al.   NEUROBIOLOGY OF DISEASE

Wnt1 Promotes EAAT2 Expression and Mediates the Protective Effects of Astrocytes on Dopaminergic Cells in Parkinson’s Disease

(2019) Lei Wei et al.   NEURAL PLASTICITY

Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke

(2019) Degang Song et al.   Journal of Neuroinflammation

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

(2019) Lin Jia et al.   Molecular Brain

Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis

(2018) Mariana Pehar et al.   CURRENT PHARMACEUTICAL DESIGN

NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

(2018) Najwa Ouali Alami et al.   EMBO JOURNAL

Amyotrophic Lateral Sclerosis: An Update for 2018

(2018) Björn Oskarsson et al.   MAYO CLINIC PROCEEDINGS

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

(2018) Marcel Naumann et al.   Nature Communications

Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

(2018) Sarah Cantor et al.   eLife

Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction

(2018) Jin Li et al.   Scientific Reports

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

(2018) Benjamin Mattes et al.   eLife

Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model

(2018) Sean J. Miller et al.   JOURNAL OF NEUROGENETICS

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

(2018) Arundhati Sengupta-Ghosh et al.   NEUROBIOLOGY OF DISEASE

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

(2017) Akshay Bhinge et al.   Stem Cell Reports

Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis

(2017) Jee-Eun Kim et al.   PLoS One

Lrp4 in astrocytes modulates glutamatergic transmission

(2016) Xiang-Dong Sun et al.   NATURE NEUROSCIENCE

Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern

(2016) Carlos González-Fernández et al.   PLoS One

N-acetyl- l -tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model

(2015) Wei Li et al.   NEUROBIOLOGY OF DISEASE

Early Gene Expression Changes in Skeletal Muscle from SOD1G93A Amyotrophic Lateral Sclerosis Animal Model

(2014) Gabriela P. de Oliveira et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Axon guidance and injury—lessons from Wnts and Wnt signaling

(2014) Keisuke Onishi et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice

(2013) Shanshan Wang et al.   BIOTECHNOLOGY LETTERS

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

(2013) Thomas Philips et al.   BRAIN

Wnt and lithium: a common destiny in the therapy of nervous system pathologies?

(2013) Delphine Meffre et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Altered expression of atypical PKC and Ryk in the spinal cord of a mouse model of amyotrophic lateral sclerosis

(2013) Anna Tury et al.   Developmental Neurobiology

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

(2013) Felipe Ortega et al.   NATURE CELL BIOLOGY

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Yi Zhang et al.   NEUROBIOLOGY OF DISEASE

Wnt Signaling is Altered by Spinal Cord Neuronal Dysfunction in Amyotrophic Lateral Sclerosis Transgenic Mice

(2013) Li Yu et al.   NEUROCHEMICAL RESEARCH

Design and Initial Results of a Multi-Phase Randomized Trial of Ceftriaxone in Amyotrophic Lateral Sclerosis

(2013) James D. Berry et al.   PLoS One

Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis

(2013) Cristina Pinto et al.   Frontiers in Cellular Neuroscience

LRP4 antibodies in serum and CSF from amyotrophic lateral sclerosis patients

(2013) John S. Tzartos et al.   Annals of Clinical and Translational Neurology

Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice

(2012) Yanchun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Initiation of synapse formation by Wnt-induced MuSK endocytosis

(2012) L. R. Gordon et al.   DEVELOPMENT

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

(2012) Carina Halleskog et al.   Journal of Neuroinflammation

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice

(2012) Yanchun Chen et al.   NEUROLOGICAL RESEARCH

Lithium enhances remyelination of peripheral nerves

(2012) J. Makoukji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Increasing MuSK Activity Delays Denervation and Improves Motor Function in ALS Mice

(2012) María J. Pérez-García et al.   Cell Reports

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SnapShot: Neuromuscular Junction

(2011) Steven J. Burden   CELL

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

(2011) Kristina Tanneberger et al.   EMBO JOURNAL

GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo

(2011) Kasum Azim et al.   GLIA

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway

(2011) Krista M. Heinonen et al.   PLoS One

Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis

(2010) M. Sahores et al.   DEVELOPMENT

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

WNT signaling in activated microglia is proinflammatory

(2010) Carina Halleskog et al.   GLIA

The “Dying-Back” Phenomenon of Motor Neurons in ALS

(2010) Michal Dadon-Nachum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Astrocyte function and role in motor neuron disease: A future therapeutic target?

(2009) Daniel Blackburn et al.   GLIA

Wnt signaling is sufficient to perturb oligodendrocyte maturation

(2009) Keith Feigenson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

(2008) Claudia Pereira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-Catenin Signaling Suppresses Rapsyn Expression and Inhibits Acetylcholine Receptor Clustering at the Neuromuscular Junction

(2008) Jia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Essential Role for Frizzled5 in Neuronal Survival in the Parafascicular Nucleus of the Thalamus

(2008) C. Liu et al.   JOURNAL OF NEUROSCIENCE

Repulsive Wnt Signaling Inhibits Axon Regeneration after CNS Injury

(2008) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin

(2008) J. P. Henriquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The first five years of the Wnt targetome

(2007) Annica Vlad et al.   CELLULAR SIGNALLING